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中华诊断学电子杂志 ›› 2014, Vol. 02 ›› Issue (04) : 245 -248. doi: 10.3877/cma.j.issn.2095-655X.2014.04.001

所属专题: 文献

影像学诊断研究

β受体阻滞剂对健康成人64层螺旋CT冠状动脉造影左心室功能的影响
张春红1, 刘军1, 梁立华2, 彭述平1,()   
  1. 1. 410011 长沙,中南大学湘雅二医院影像科
    2. 深圳市第四人民医院影像科
  • 收稿日期:2014-06-15 出版日期:2014-11-26
  • 通信作者: 彭述平
  • 基金资助:
    国家临床重点专科建设项目(2013年); 湖南省科技厅项目(2009FJ3092)

The effects of propranolol on the left ventricular function by 64-slice multi-slice computed tomography

Chunhong Zhang1, Jun Liu1, Lihua Liang2, Shuping Peng1,()   

  1. 1. Department of Radiology, Second Xiangya Hosipital, Cental South University, Hunan 410011, China
  • Received:2014-06-15 Published:2014-11-26
  • Corresponding author: Shuping Peng
  • About author:
    Corresponding author: Peng Shuping, Email:
引用本文:

张春红, 刘军, 梁立华, 彭述平. β受体阻滞剂对健康成人64层螺旋CT冠状动脉造影左心室功能的影响[J]. 中华诊断学电子杂志, 2014, 02(04): 245-248.

Chunhong Zhang, Jun Liu, Lihua Liang, Shuping Peng. The effects of propranolol on the left ventricular function by 64-slice multi-slice computed tomography[J]. Chinese Journal of Diagnostics(Electronic Edition), 2014, 02(04): 245-248.

目的

研究64层螺旋CT(64SCT)冠状动脉造影,β受体阻滞剂对健康成人左心室功能的影响。

方法

收集行64SCT冠状动脉造影(64SCTA)检查未发现冠状动脉狭窄的被试178例,其中89例检查前未服用β受体阻滞剂(普萘洛尔),另外89例年龄和性别相匹配的患者(检查前心率>70次/min)服用β受体阻滞剂调整心率。记录用药前后心率(HR)、收缩压(SBP)和舒张压(DBP)及普萘洛尔剂量。测定左心功能指标:舒张末期容积(EDV)、收缩末期容积(ESV)、射血分数(EF)。未服用和服用普萘洛尔组左心功能结果应用配对t检验进行统计分析。

结果

未服用和服用普萘洛尔两组间的SBP和DBP的差异无统计学意义[分别为(124±14)mmHg和(121±13)mmHg,t=1.04,P>0.05;(81±9)mmHg和(79±10)mmHg,t=1.44,P>0.05;(1 mmHg=0.133 pKa)]。EDV两组之间差异无统计学意义[分别为(127.5±16.4)ml和(129.8±15.1)ml,t=-1.22,P>0.05],而ESV和EF在这两组之间的差异有统计学意义[分别为(44.7±12.3)ml和(47.3±13.4)ml,t=2.47,P<0.05;(65.1±8.4)%和(62.0±7.8)%,t=2.39,P<0.05];服用普萘洛尔组ESV不同程度的增加,而EF下降。

结论

64SCTA应用β受体阻滞剂,可致ESV增加,EF降低,而SBP、DBP和EDV的差异无统计学意义。

Objective

To investigate the effects of propranolol on the left ventricular (LV) function by CT coronary angiography.

Methods

One hundred and seventy-eight subjects without coronary artery stenosis were examined by 64SCT coronary angiography (64SCTA). Eight-nine subjects did not take propranolol while another eight-nine age-and gender-matched subjects whose heart rates above 70 beats were chosen to take propranolol.The heart rate, systolic blood pressure (SBP), and diastolic blood pressure (DBP) before and after the administration of propranolol and the dosage of propranolol were recorded.The left ventricular function was calculated by parameters of end-diastolic volume(EDV), end systolic volume(ESV) and ejection fraction(EF). The paired-t test was used to compare the left ventricular function between the two groups (no taking and taking propranolol).

Results

There were no significant differences in the SBP and DBP between the groups without and with propranolol medication [(124±14)mmHg and (81±9)mmHg; (121±13)mmHg and (79±10)mmHg, respectively)]. The EDV showed no significant differences between the two groups, but the ESV and EF showed significant differences between the two groups[(44.7±12.3)mL and (47.3±13.4)mL; (65.1±8.4)% and (62.0±7.8)%, respectively)].

Conclusions

Taking propranolol increases ESV and decreases EF, while the SBP, DBP and EDV don′t change.

表1 两组被试一般情况比较(±s)
表2 两组被试血压及心功能64SCT评价结果比较(±s)
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