切换至 "中华医学电子期刊资源库"

中华诊断学电子杂志 ›› 2015, Vol. 03 ›› Issue (02) : 122 -127. doi: 10.3877/cma.j.issn.2095-655X.2015.02.011

所属专题: 文献

临床思维

应用神经决策学方法探讨精神心理相关疾病发病机制的思考
郭宗君1,(), 刘世恩2, 高振波3, 孙波3, 陈娟1, 李玉焕3   
  1. 1. 266003 青岛大学附属医院保健科
    2. 266003 青岛大学附属医院影像科
    3. 266034 青岛市精神卫生中心精神科
  • 收稿日期:2014-12-12 出版日期:2015-05-26
  • 通信作者: 郭宗君
  • 基金资助:
    山东省科技发展计划项目(2011YD18045); 山东省自然科学基金(ZR2012HM049); 山东省保健基金资助项目(2007BZ19); 青岛市科技局基金资助项目(Kzd-03;09-1-1-33-nsh)

The research on the pathogenesis of the related mental and psychological diseases with decision neuroscience

Zongjun Guo1,(), Shien Liu2, Zhenbo Gao3, Bo Sun3, Juan Chen1, Yuhuan Li3   

  1. 1. Department of the Institute of Brain Science and Human Resource Management, Qingdao University, Qingdao 266003, China
    2. Department of Imaging, Qingdao University, Qingdao 266003, China
    3. Department of Psychiatry, Mental Health Center of Qingdao City, Qingdao 266034, China
  • Received:2014-12-12 Published:2015-05-26
  • Corresponding author: Zongjun Guo
  • About author:
    Corresponding author: Guo Zongjun, Email:
引用本文:

郭宗君, 刘世恩, 高振波, 孙波, 陈娟, 李玉焕. 应用神经决策学方法探讨精神心理相关疾病发病机制的思考[J]. 中华诊断学电子杂志, 2015, 03(02): 122-127.

Zongjun Guo, Shien Liu, Zhenbo Gao, Bo Sun, Juan Chen, Yuhuan Li. The research on the pathogenesis of the related mental and psychological diseases with decision neuroscience[J]. Chinese Journal of Diagnostics(Electronic Edition), 2015, 03(02): 122-127.

许多心理精神相关疾病如边缘人格障碍、孤独症、社会恐惧症、抑郁症、焦虑症等具有社会人际功能障碍的特征。如社交恐惧症患者对社会结果过度敏感;抑郁症患者对负性结果敏感性增高,对社会奖励信号反应迟钝,对负性情绪敏感性增高等;焦虑障碍患者在社会价值评估或社会概率评估方面对负性概率事件敏感性增高,导致其社会学习负性偏向和人际功能损伤。这些改变均与其决策加工过程异常有关。神经决策学是认知神经科学与经济学和定量计算科学交叉融合产生的一门学科,其提供了许多具有特征性的研究范式,如社会价值评估、社会风险选择等,可以观察社会人际功能及行为相互作用的变化,从而探讨诸如焦虑、抑郁等相关心理疾病的发病机制。应用神经决策任务范式结合脑影像基因学技术可以探讨患有心理精神相关疾病患者社会困难的行为学机制和神经生物学机制。这些技术在研究人际社会正常功能以及功能障碍方面提供了一个较好的架构,可以发现一些定量性的生物标记指标。因此,作为一个新颖的应用研究方向,值得深入探讨。

Many mental and psychological diseases such as borderline personality disorder (BPD), autism (ASD), social phobia, depression, and anxiety have the characteristics of social interpersonal dysfunction.Patients with social phobia are excessively sensitive to social outcomes.Patients with depression increase their sensitivity to negative results, they are unresponsive to social reward signal and are more sensitive to negative emotions.Patients with anxiety disorder amplify the sensitivity to the negative probability events in the evaluation of social value evaluation or social probability, leading to negative bias in social learning and interpersonal function injury.These changes are related to their decision-making process.The intersection of cognitive neural science, economics and quantitative calculation produces a new interdisciplinary science, decision neuroscience, which provides many characteristic research paradigm, such as social value, social risk selection, and it can observe the changes in interpersonal function and interaction of social behaviors, so as to investigate the mechanism of mental disorders such as anxiety, and depression.Application of neural decision making task paradigm with brain imaging genetics technology can explore the behavior and neurobiology mechanism of patients suffering from mental and psychological diseases with social difficulties.These techniques provide a good framework in the study of social function and dysfunction, and are helpful to find biomarkers of quantitative indicators of the mental and psychological related diseases.Therefore, as a new research direction, it is worthy of further discussion.

[1]
Huettel SA,Stowe CJ,Gordon EM, et al.Neural signatures of economic preferences for risk and ambiguity[J]. Neuron, 2006, 49(5): 765-775.
[2]
徐小静,郭宗君. 不同部位脑梗死患者抉择加工研究[J]. 中华行为医学与脑科学杂志, 2013, 22(1): 21-24.
[3]
Sharp ME,Viswanathan J,Lanyon LJ, et al.Sensitivity and bias in decision-making under risk:evaluating the perception of reward, its probability and value[J]. PLoS One, 2012, 7(4): e33460.
[4]
陈娟,郭宗君,刘世恩, 等. 正常健康者不确定奖赏抉择加工过程激活脑区分析[J]. 中华行为医学与脑科学杂志, 2013, 22(3): 6-8.
[5]
汪蕾,沈翔宇,林志萍. 基于决策神经科学的风险决策与含糊决策研究进展[J]. 东南大学学报(医学版), 2010, 29(4): 76-80.
[6]
Padoa-Schioppa C,Assad JA.Neurons in the orbitofrontal cortex encode economic value[J]. Nature, 2006, 441(7090): 223-226.
[7]
Jollant F,Lawrence NS,Olie E, et al.Decreased activation of lateral orbitofrontal cortex during risky choices under uncertainty is associated with disadvantageous decision-making and suicidal behavior[J]. NeuroImage, 2010, 51(3): 1275-1281.
[8]
席春华,傅先明,汪凯, 等. 前额叶损伤患者的风险决策认知障碍[J]. 中华医学杂志, 2006, 86(45): 3169-3172.
[9]
Han S,Huettel SA,Dobbins IG.Rule-dependent Prefrontal Cortex Activity across Episodic and Perceptual Decisions:An fMRI Investigation of the Criterial Classification Account[J]. J cog neurosci, 2009, 21(5): 922-937.
[10]
Domenech P,Dreher JC.Decision threshold modulation in the human brain[J]. Neurosci, 2010, 30(43): 14305-14317.
[11]
Yu R,Zhou X. To bet or not to bet? The error negativity or error-related negativity associated with risk-taking choices[J]. J Cog Neurosci, 2009, 21(4): 684-696.
[12]
Ernst M,Nelson EE,McClure EB, et al.Choice selection and reward anticipation:an fMRI study[J]. Neuropsychologia, 2004, 42(12): 1585-1597.
[13]
Venkatraman V,Payne JW,Bettman JR, et al.Separate neural mechanisms underlie choices and strategic preferences in risky decision making[J]. Neuron, 2009, 62(4): 593-602.
[14]
Ahn WY,Busemeyer JR,Wagenmakers EJ, et al.Comparison of decision learning models using the generalization criterion method[J]. Cogn Sci, 2008, 32(8): 1376-1402.
[15]
Kahneman D. A perspective on judgment and choice:mapping bounded rationality[J]. Am Psychol, 2003, 58(9): 697-720.
[16]
Hsu M,Bhatt M,Adolphs R, et al.Neural systems responding to degrees of uncertainty in human decision-making[J]. Science, 2005, 310(5754): 1680-1683.
[17]
Congdon E,Bato AA,Schonberg T, et al.Differences in neural activation as a function of risk-taking task parameters[J]. Front Neurosci, 2013, 30(7): 173.
[18]
Brand M,Grabenhorst F,Starcke K, et al.Role of the amygdala in decisions under ambiguity and decisions under risk:Evidence from patients with Urbach-Wiethe disease[J]. Neuropsychologia, 2007, 45(6): 1305-1317.
[19]
Kunisato Y,Okamoto Y,Ueda K, et al.Effects of depression on reward-based decision making and variability of action in probabilistic learning[J]. J Behav Ther Exp Psychiat, 2012, 43(4): 1088-1094.
[20]
Knutson B,Wimmer GE,Kuhnen CM, et al.Nucleus accumbens activation mediates the influence of reward cues on financial risk taking[J]. Neuroreport, 2008, 19(5): 509-513.
[21]
Dickhaut J,McCabe K,Nagode JC, et al.The impact of the certainty context on the process of choice[J]. Proc Natl Acad Sci USA, 2003, 100(6): 3536-3541.
[22]
Rolls ET,McCabe C,Redoute J. Expected value, reward outcome, and temporal difference error representations in a probabilistic decision task[J]. Cerebral Cortex, 2008, 18(3): 652-663.
[23]
Gupta R,Koscik TR,Bechara A, et al.The amygdala and decision making[J]. Neuropsychologia, 2011, 49(4): 760-766.
[24]
Pessoa L. Emotion and cognition and the amygdala:from "what is it?" to "what’s to be done" [J]. Neuropsychologia, 2010, 48(12): 3416-3429.
[25]
Sanfey AG,Rilling JK,Aronson JA, et al.The neural basis of economic decision-making in the ultimatum game[J]. Science, 2003, 300(5626): 1755-1758.
[26]
De Martino B,Kumaran D,Seymour B, et al.Frames, biases, and rational decision-making in the human brain[J]. Science, 2006, 313(5787): 684-687.
[27]
King-casas B,Chiu PH.Understanding interpersonal function in psychiatric illness through multiplayer economic games[J]. Biol Psychiatry, 2012, 72(2): 119-125.
[28]
Lee D. Game theory and neural basis of social decision making[J]. Nat Neurosci, 2008, 11(4): 404-409.
[29]
Koenigs M,Kruepke M,Newman JP.Economic decision-making in psychopathy:a comparison with ventromedial prefrontal lesion patients[J]. Neuropsychologia, 2010, 48(7): 2198-2204.
[30]
Rilling JK,Glenn AL,Jairam MR, et al.Neural correlates of social cooperation and non-cooperation as a function of psychopathy[J]. Biol Psychiatry, 2007, 61(11): 1260-1271.
[31]
Amodio DM,Frith CD.Meeting of minds:The medial frontal cortex and social cognition[J]. Nat Rev Neurosci, 2006, 7(4): 268-277.
[32]
Henriques JB,Davidson RJ.Decreased responsiveness to reward in depression[J]. Cogn Emot, 2000(14): 711-724.
[33]
Drevets WC.Functional neuroimaging studies of depression:the anatomy of melancholia[J]. Annu Rev Med, 1998(49): 341-361.
[34]
Banich MT,Mackiewicz KL,Depue BE, et al.Cognitive control mechanisms, emotion and memory:A neural perspective with implications for psychopathology[J]. Neurosci Biobehavl Rev, 2009, 33(5): 613-630.
[35]
Holmes AJ,Pizzagalli DA.Spatiotemporal dynamics of error processing dysfunctions in major depressive disorder[J]. Arch Gen Psychiatry, 2008, 65(2): 179-188.
[36]
St Onge JR,Floresco SB.Prefrontal cortical contribution to risk-based decision making[J]. Cereb Cortex, 2010, 20(8): 1816-1828.
[37]
Krishnan V,Han MH,Graham DL, et al.Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions[J]. Cell, 2007, 131(2): 391-404.
[38]
赵汉清,过伟,余海鹰, 等. 部队心理医生综合诊疗系统的研制[J/CD]. 中华诊断学电子杂志, 2014, 2(1): 67-69.
[1] 徐一宏, 李朔, 徐卫东. 分子标记物在假体周围感染诊断中的应用[J]. 中华关节外科杂志(电子版), 2019, 13(04): 455-460.
[2] 冯瑞宾, 罗世兴, 赵劲民, 张美瑜. 蛋白组学在骨关节炎中的研究进展[J]. 中华关节外科杂志(电子版), 2018, 12(06): 830-834.
[3] 贺晓楠, 赵冠棋, 张彦龙, 孙立忠, 聂绍平. 急性Stanford A型主动脉夹层急诊手术患者预后相关生物标记物的分析研究[J]. 中华危重症医学杂志(电子版), 2018, 11(02): 73-77.
[4] 陈丽妮, 乔莉娜. 实验室指标在早期鉴别诊断脓毒症和川崎病中的应用[J]. 中华妇幼临床医学杂志(电子版), 2022, 18(04): 460-467.
[5] 李泽乾, 郝少龙, 张博, 纪凯伦, 韩威. 外周血非编码RNA在胰腺癌中研究进展[J]. 中华普外科手术学杂志(电子版), 2023, 17(02): 217-220.
[6] 李慧婷, 莫冉冉, 宋鹏, 李明娴. 非小细胞肺癌免疫检查点抑制剂治疗进展[J]. 中华肺部疾病杂志(电子版), 2019, 12(03): 382-386.
[7] 周小妹, 罗波, 梁新军. 循环生物标志物在直肠癌新辅助放化疗疗效预测中的应用[J]. 中华结直肠疾病电子杂志, 2021, 10(04): 399-403.
[8] 李斌, 董哲毅, 荣向路, 陈香美. 糖尿病肾脏疾病生物标记物的研究进展[J]. 中华肾病研究电子杂志, 2018, 07(02): 82-85.
[9] 何明骏, 姚高峰, 张理义, 孔令明, 牛威, 陈升东, 仲爱芳. 长链非编码RNA在精神分裂症的变化与阳性、阴性症状的研究[J]. 中华脑科疾病与康复杂志(电子版), 2017, 07(02): 64-70.
[10] 王亚飞, 吴振彪. 自身抗体在皮肌炎患者管理中的应用[J]. 中华临床医师杂志(电子版), 2022, 16(08): 796-800.
[11] 苏淼, 赵东强. 肝内胆管癌预后因素的研究进展[J]. 中华胃肠内镜电子杂志, 2023, 10(01): 62-66.
阅读次数
全文


摘要