切换至 "中华医学电子期刊资源库"

中华诊断学电子杂志 ›› 2016, Vol. 04 ›› Issue (01) : 19 -22. doi: 10.3877/cma.j.issn.2095-655X.2016.01.006

所属专题: 文献

爆炸冲击伤诊治研究

细胞因子生物标志物在爆炸致急性肺损伤检测中的应用
陈魁君1, 王建民1,()   
  1. 1. 400042 重庆,第三军医大学大坪医院野战外科研究所 创伤烧伤与复合伤国家重点实验室
  • 收稿日期:2015-12-16 出版日期:2016-02-26
  • 通信作者: 王建民
  • 基金资助:
    国家自然科学基金(81270119)

Application of cytokines/biomarkers in the detection of acute lung injury induced by explosions

Kuijun Chen1, Jianmin Wang1,()   

  1. 1. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
  • Received:2015-12-16 Published:2016-02-26
  • Corresponding author: Jianmin Wang
  • About author:
    Corresponding author: Wang Jianmin, Email:
引用本文:

陈魁君, 王建民. 细胞因子生物标志物在爆炸致急性肺损伤检测中的应用[J/OL]. 中华诊断学电子杂志, 2016, 04(01): 19-22.

Kuijun Chen, Jianmin Wang. Application of cytokines/biomarkers in the detection of acute lung injury induced by explosions[J/OL]. Chinese Journal of Diagnostics(Electronic Edition), 2016, 04(01): 19-22.

爆炸冲击伤在现代战争、民用爆破及恐怖袭击中的发生比例日益增加,肺脏作为爆炸冲击伤的最敏感靶器官之一,在冲击伤发生发展过程中最具有代表性。原发肺冲击伤导致急性肺损伤和急性呼吸窘迫综合征是其主要死亡原因。根据肺冲击伤病情发展的不同阶段,目前可以通过相关的生物标志物的检测来进行诊断与评估,笔者就目前爆炸致急性肺损伤检测的主要生化标志物进行综述,为爆炸冲击伤发展过程的动态观测提供依据。

Blast injury is seen with increasing frequency worldwide in military conflicts, civilian settings and terrorist bombing attacks.In fact, lung is known as one of the most critical organs in blast injury, which is considered to be the most representative damage in the explosion.Moreover, acute lung injury and acute respiratory distress syndrome, induced by primary blast lung injury, are the major cause of immediate death.According to the pathological processes of blast lung injury, biomarkers are used in the diagnosis and evaluation of this kind of injury.In this review, we introduced several biomarkers which are the major diagnosis makers for blast lung injury, and it would provide support for the dynamic observation during the development of blast lung injury.

[1]
Belanger HG,Tracy K,Ruth YG, et al.Cognitive sequelae of blast-related versus other mechanisms of brain trauma[J]. J Int Neuropsychol Soc, 2009, 15(1): 1-8.
[2]
Mcdonald JA,Ballard M. Primary Blast Lung Injury[J]. Am J Respir Crit Care Med, 2015, 191(12): 1462-1463.
[3]
Singleton JA,Gibb IE,Bull AM, et al.Primary blast lung injury prevalence and fatal injuries from explosions:insights from postmortem computed tomographic analysis of 121 improvised explosive device fatalities[J]. J Trauma Acute Care Surg, 2013, 75(2 Suppl 2): S269-S274.
[4]
Cereda M,Xin Y,Meeder N, et al.Visualizing the propagation of acute lung injury[J]. Anesthesiology, 2016, 124(1): 121-131.
[5]
Knöferl MW,Liener UC,Seitz DH, et al.Cardiopulmonary, histological and inflammatory alterations after lung contusion in a novel mouse model of blunt chest trauma[J]. Shock, 2003, 19(6): 519-525.
[6]
Nicolas B,Ware LB.Biomarkers in Acute Lung injury-marking forward progress[J]. Critical Care Clinics, 2011, 27(3): 661-683.
[7]
Fiedler U,Augustin HG.Angiopoietins:a link between angiogenesis and inflammation[J]. Trends Immunol, 2006, 27(12): 552-558.
[8]
Jones PF.Not just angiogenesis-wider roles for the angiopoietins[J]. J Pathol, 2003, 201(4): 515-527
[9]
Calfee CS,Gallagher D,Abbott J, et al.Plasma angiopoietin-2 in clinical acute lung injury:prognostic and pathogenetic significance[J]. Crit Care Med, 2012, 40(6): 1731-1737.
[10]
Fogli S,Mogavero S,Egan CG, et al.Pathophysiology and pharmacological targets of VEGF in diabetic macular edema[J]. Pharmacol Res, 2015(103): 149-157.
[11]
Prokosch V,Fink J,Heiduschka P, et al.VEGF, Ang-2 and SRIF associated abnormal postnatal development of the retinal capillary network in the royal college of surgeons rat[J]. Exp Eye Res, 2011, 92(2): 128-137.
[12]
Huang J,Bae JO,Tsai JP, et al.Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade[J]. Int J Oncol, 2009, 34(1): 79-87.
[13]
Thickett DR,Armstrong L,Christie SJ, et al.Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome[J]. Am J Respir Crit Care Med, 2001, 164(9): 1601-1605.
[14]
Abadie Y,Bregeon F,Papazian L, et al.Decreased VEGF concentration in lung tissue and vascular injury during ARDS[J]. Eur Respir J, 2005, 25(1): 139-146.
[15]
Marianor M,Zaidah AW,Maraina ChC.Von willebrand factor propeptide:A potential disease biomarker not affected by ABO blood groups[J]. Biomark Insights, 2015(10): 75-79.
[16]
殷杰,阮长耿. 血管性血友病因子前导肽的作用及临床价值[J]. 中华血液学杂志, 2015, 36(10): 883-887.
[17]
Ware LB,Conner ER,Matthay MA.Von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury[J]. Crit Care Med, 2001, 29(12): 2325-2331.
[18]
Matthay MA,Zemans RL.The acute respiratory distress syndrome:pathogenesis and treatment[J]. Annu Rev Pathol, 2011, 6(1): 147-163.
[19]
Vanden steen PE,Deroost K,Deckers J, et al.Pathogenesis of malaria-associated acute respiratory distress syndrome[J]. Trends Parasitol, 2013, 29(7): 346-358.
[20]
Beileke S,Claassen H,Wagner W, et al.Expression and localization of lung surfactant proteins in Human Testis[J]. PLoS One, 2015, 10(11): e0143058.
[21]
Wang Y,Voelker DR,Lugogo NL, et al.Surfactant protein A is defective in abrogating inflammation in asthma[J]. Am J Physiol Lung Cell Mol Physiol, 2011, 301(4): L598-606.
[22]
Park HY,Churg A,Wright JL, et al.Club cell protein 16 and disease progression in chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med, 2013, 188(12): 1413-1419.
[23]
Kropski JA,Fremont RD,Calfee CS, et al.Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury[J]. Chest, 2009, 135(6): 1440-1447.
[24]
Determann RM,Millo JL,Waddy S, et al.Plasma CC16 levels are associated with development of ALI/ARDS in patients with ventilator-associated pneumonia:a retrospective observational study[J]. B Pulm Med, 2009(9): 49.
[25]
Mc Donald Johnston A,Ballard M. Primary Blast Lung Injury[J]. Am J Respir Crit Care Med, 2015, 191(12): 1462-1463.
[26]
Cross LJ,Matthay MA.Biomarkers in acute lung injury:insights into the pathogenesis of acute lung injury[J]. Critical Care Clinics, 2011, 27(2)L355-377.
[27]
Christophe Q,Sylvain MA,Aurélie F, et al.Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury[J]. Am J Physiol Lung Cell Mol Physiol, 2008, 294(2): L334-L343.
[28]
Yang G,Hamacher J,Gorshkov B, et al.The dual role of TNF in pulmonary edema[J]. J Cardiovasc Dis Res, 2010, 1(1): 29-36.
[29]
Epanchintsev A,Shyamsunder P,Verma RS, et al.IL-6, IL-8, MMP-2, MMP-9 are overexpressed in fanconi anemia cells through a NF-kappaB/TNF-alpha dependent mechanism[J]. Mol Carcinog, 2015, 54(12): 1686-1699.
[30]
侯晓彬,易定华,李廷慧, 等. P38丝裂原活化蛋白激酶和核转录因子κBP65在胸部爆炸伤致急性肺损伤中的作用[J]. 中华急诊医学杂志, 2005, 14(1)26-29.
[31]
Lindsay CD.Novel therapeutic strategies for acute lung injury induced by lung damaging agents:the potential role of growth factors as treatment options[J]. Hum Exp Toxicol, 2011, 30(7): 701-724.
[32]
González-López A,Albaiceta GM.Repair after acute lung injury:molecular mechanisms and therapeutic opportunities[J]. Critical Care, 2012, 16(2): 1-7.
[33]
Ware LB,Bastarache JA,Wang L. Coagulation and fibrinolysis in human acute lung injury-new therapeutic targets? [J]. Keio J Med, 2005, 54(3): 142-149.
[34]
Ashish A,Hanjing Z,Sandra B, et al.Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness:results from two clinical trials[J]. Am J Physiol Lung Cell Mol Physiol, 2012, 303(8): L634-639.
[1] 郝玥萦, 毛盈譞, 张羽, 汪佳旭, 韩林霖, 匡雯雯, 孟瑶, 杨秀华. 超声引导衰减参数成像评估肝脂肪变性及其对心血管疾病风险的预测价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(08): 770-777.
[2] 李霞林, 贺芳. 产后出血风险评估和早期预警系统[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 498-503.
[3] 雷子威, 凌萍, 沈纵, 魏晨如, 朱邦晖, 伍国胜, 孙瑜. 类器官肺损伤疾病模型构建及应用的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 531-535.
[4] 唐金侨, 叶宇佳, 王港, 赵彬, 马艳宁. 医学影像学检查方法在颞下颌关节紊乱病中临床应用研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(06): 406-411.
[5] 刘明辉, 葛方明. MRI 对腹股沟疝修补术后患者早期并发症的评估价值研究[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 579-583.
[6] 张敏龙, 杨翠平, 王博, 崔云杰, 金发光. MiR-200b-3p 通过抑制HIF-1α 表达减轻海水吸入诱导的肺水肿作用及机制[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 696-700.
[7] 井发红, 李丽娜, 高婷, 高艳梅, 杨楠, 李卓, 慕玉东. 肺癌立体定向放疗血清SAP 和MMPs 表达及临床意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 707-713.
[8] 周迪, 全志伟. 规范化胆囊良性疾病诊治流程减少胆囊癌误诊误治[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 749-753.
[9] 吴警, 吐尔洪江·吐逊, 温浩. 肝切除术前肝功能评估新进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 889-893.
[10] 梁艳娉, 列诗韵, 王艺穗, 吴晓瑛, 林颖. 基于内镜操作细节记录系统构建胃底静脉曲张内镜下组织胶注射术的标准化管理方案[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 705-709.
[11] 程柏凯, 杨光. 高胰岛素-正葡萄糖钳夹技术评估慢性肾脏病患者胰岛素抵抗的研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(06): 334-339.
[12] 杨智钧, 谷佳, 丁聿贤, 张正奎, 于如同. 脑胶质瘤患者血清炎性因子水平与病理分级及预后的相关性[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(04): 238-242.
[13] 刘婷, 杨少康, 陈亿霏, 刘悦, 潘纯. 气道闭合的监测在机械通气中的研究进展[J/OL]. 中华重症医学电子杂志, 2024, 10(04): 394-398.
[14] 孙文恺, 沈青, 杭丽, 张迎春. 纤维蛋白原与清蛋白比值、中性粒细胞与白蛋白比值、C反应蛋白与溃疡性结肠炎病情评估和预后的关系[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 426-431.
[15] 何玉花, 钟欢妹, 王文惠, 沈永棋, 刘映云, 顾国威, 陈丹娜. 不同表型多囊卵巢综合征患者代谢指标及肥胖相关指标对多囊卵巢综合征合并代谢综合征人群的诊断效能分析[J/OL]. 中华临床实验室管理电子杂志, 2024, 12(04): 212-220.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?