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中华诊断学电子杂志 ›› 2016, Vol. 04 ›› Issue (03) : 145 -148. doi: 10.3877/cma.j.issn.2095-655X.2016.03.001

所属专题： 文献；

消化系统疾病与心身医学观

功能性消化不良患者血浆神经肽Y和P物质水平与焦虑抑郁情绪的相关性
梁慧敏1,†(), 梁军辉2, 高洋1   
  1. 1. 475000　开封，河南大学淮河医院神经内科
    2. 462500　平顶山舞钢市人民医院检验科
  • 收稿日期:2016-07-22 出版日期:2016-08-26
  • 通信作者: 梁慧敏
  • 基金资助:
    河南省科技厅科学技术研究重点项目(142300410368); 河南省教育厅科学技术研究重点项目(14B320019); 河南省科技厅国际科技合作项目(152102410025)

Correlation of plasma neuropeptide Y and substance P levels with anxiety and depression in patients with functional dyspepsia

Huimin Liang1,†(), Junhui Liang2, Yang Gao1   

  1. 1. Department of Neurology, Huaihai Hospital of Henan University, Kaifeng 475000, China
    2. Department of Clinical Laboratory, The People′s Hospital of Wu Gang, Wugang 462500, China
  • Received:2016-07-22 Published:2016-08-26
  • Corresponding author: Huimin Liang
  • About author:
    Corresponding author: Liang Huimin, Email:
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梁慧敏, 梁军辉, 高洋. 功能性消化不良患者血浆神经肽Y和P物质水平与焦虑抑郁情绪的相关性[J]. 中华诊断学电子杂志, 2016, 04(03): 145-148.

Huimin Liang, Junhui Liang, Yang Gao. Correlation of plasma neuropeptide Y and substance P levels with anxiety and depression in patients with functional dyspepsia[J]. Chinese Journal of Diagnostics(Electronic Edition), 2016, 04(03): 145-148.

目的

探讨功能性消化不良(FD)患者血浆神经肽Y(NPY)和P物质(SP)水平与焦虑抑郁情绪的相关性。

方法

通过采用焦虑自评量表(SAS)和抑郁自评量表(SDS)评定30例FD患者和30名健康志愿者的焦虑抑郁水平。采集受试者外周血，采用酶联免疫吸附法(ELISA)检测血浆中NPY和SP的水平。

结果

健康对照组NPY和SP水平分别为(118.53±22.29)ng/L和(47.65±11.06)ng/L，FD组NPY和SP水平分别为(94.82±18.53)ng/L和(35.16±8.42)ng/L，差异有统计学意义(t＝8.13，7.04；P<0.01)。FD组SAS和SDS评分分别为(67.4±14.2)分和(63.9±13.5)分，健康对照组分别为(44.6±11.7)分和(41.1±10.6)分，差异有统计学意义(t＝12.44，11.18；P<0.01)。FD患者和伴焦虑抑郁情绪FD患者在性别、年龄和病程时间方面差异无统计学意义(χ2＝1.22，0.56，2.14；P>0.05)。FD患者血浆NPY水平与SAS和SDS评分均呈负相关(r＝－0.70，－0.61，P<0.01)，FD患者血浆SP水平与SAS和SDS评分均呈负相关(r＝－0.74，－0.56；P<0.01)。

结论

FD患者血浆NPY和SP水平降低，并且与焦虑抑郁评分呈负相关性，NPY和SP可能在伴焦虑抑郁情绪功能性消化不良发病机制中起重要作用。

关键词: 功能性消化不良, 神经肽Y, P物质, 焦虑, 抑郁
Objective

To investigate the correlation between plasma neuropeptide tyrosine (NPY) and substance P (SP) levels and anxiety and depression in patients with functional dyspepsia (FD).

Methods

Anxiety and depression scores of 30 patients with FD and 30 healthy volunteers were obtained by self-rating anxiety scale (SAS) and self-rating depression scale (SDS). The peripheral blood of participants was collected and the enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of plasma NPY and SP.

Results

The levels of NPY and SP were (94.82±18.53)ng/L and (35.16±8.42)ng/L in the FD group respectively, and were (118.53±22.29)ng/L and (47.65±11.06)ng/L in the healthy controls respectively, the differences were statistically significant (t=8.13, 7.04; P<0.01). SAS and SDS scores were (67.4±14.2) and (63.9±13.5) in the FD group respectively, and were (44.6±11.7) and (41.1±10.6) in the healthy controls respectively, the differences were statistically significant (t=12.44, 11.18; P<0.01). There were no significant differences in gender, age and disease duration between FD patients and FD patients with anxiety and depression(χ2=1.22, 0.56, 2.14; P>0.05). The plasma NPY levels in FD patients were negatively correlated with SAS and SDS scores (r=-0.70, -0.61; P<0.001). The plasma SP levels in FD patients were negatively correlated with SAS and SDS scores (r=-0.74, -0.56; P<0.01).

Conclusions

The levels of plasma NPY and SP in FD patients are reduced, and negatively correlated with anxiety and depression scores. SP and NPY may be involved in the pathogenesis of functional dyspepsia with anxiety and depression.

Key words: Functional dyspepsia, Neuropeptide Y, Substance P, Anxiety, Depression
表1 FD组和健康对照组NPY和SP水平比较(ng/L，±s)
组别 例数 NPY SP
FD组 30 94.82±18.53 35.16± 8.42
健康对照组 30 118.53±22.29 47.65±11.06
t值 ? 8.13 7.04
P值 ? <0.01 <0.01
表2 FD组和健康对照组焦虑抑郁评分比较(分，±s)
组别 例数 SAS SDS
FD组 30 67.4±14.2 63.9±13.5
健康对照组 30 44.6±11.7 41.1±10.6
t值 ? 12.48 11.18
P值 ? <0.01 <0.01
表3 伴与不伴焦虑抑郁情绪FD患者的基本特征比较(例数)
变量 例数 FD患者 伴焦虑抑郁情绪FD患者 χ2值 P值
性别 ? ? ? 1.22 >0.05
? 男 13 8 5 ? ?
? 女 17 7 10 ? ?
年龄(岁) ? ? ? 0.56 >0.05
? ≤40 12 5 7 ? ?
? >40 18 10 8 ? ?
病程(月) ? ? ? 2.14 >0.05
? ≤12 16 10 6 ? ?
? >12 14 5 9 ? ?
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