功能性消化不良患者血浆神经肽Y和P物质水平与焦虑抑郁情绪的相关性

doi:10.3877/cma.j.issn.2095-655X.2016.03.001

中华诊断学电子杂志 ›› 2016, Vol. 04 ›› Issue (03) : 145 -148. doi: 10.3877/cma.j.issn.2095-655X.2016.03.001

所属专题：文献；

消化系统疾病与心身医学观

功能性消化不良患者血浆神经肽Y和P物质水平与焦虑抑郁情绪的相关性

梁慧敏¹^,^†(

), 梁军辉², 高洋¹

^1. 475000　开封，河南大学淮河医院神经内科
^2. 462500　平顶山舞钢市人民医院检验科

收稿日期:2016-07-22 出版日期:2016-08-26
通信作者: 梁慧敏
基金资助:
河南省科技厅科学技术研究重点项目(142300410368); 河南省教育厅科学技术研究重点项目(14B320019); 河南省科技厅国际科技合作项目(152102410025)

Correlation of plasma neuropeptide Y and substance P levels with anxiety and depression in patients with functional dyspepsia

Huimin Liang¹^,^†(), Junhui Liang², Yang Gao¹

^1. Department of Neurology, Huaihai Hospital of Henan University, Kaifeng 475000, China
^2. Department of Clinical Laboratory, The People′s Hospital of Wu Gang, Wugang 462500, China

Received:2016-07-22 Published:2016-08-26
Corresponding author: Huimin Liang
About author:
Corresponding author: Liang Huimin, Email: 151729513@qq.com

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目的

探讨功能性消化不良(FD)患者血浆神经肽Y(NPY)和P物质(SP)水平与焦虑抑郁情绪的相关性。

方法

通过采用焦虑自评量表(SAS)和抑郁自评量表(SDS)评定30例FD患者和30名健康志愿者的焦虑抑郁水平。采集受试者外周血，采用酶联免疫吸附法(ELISA)检测血浆中NPY和SP的水平。

结果

健康对照组NPY和SP水平分别为(118.53±22.29)ng/L和(47.65±11.06)ng/L，FD组NPY和SP水平分别为(94.82±18.53)ng/L和(35.16±8.42)ng/L，差异有统计学意义(t＝8.13，7.04；P<0.01)。FD组SAS和SDS评分分别为(67.4±14.2)分和(63.9±13.5)分，健康对照组分别为(44.6±11.7)分和(41.1±10.6)分，差异有统计学意义(t＝12.44，11.18；P<0.01)。FD患者和伴焦虑抑郁情绪FD患者在性别、年龄和病程时间方面差异无统计学意义(χ²＝1.22，0.56，2.14；P>0.05)。FD患者血浆NPY水平与SAS和SDS评分均呈负相关(r＝－0.70，－0.61，P<0.01)，FD患者血浆SP水平与SAS和SDS评分均呈负相关(r＝－0.74，－0.56；P<0.01)。

结论

FD患者血浆NPY和SP水平降低，并且与焦虑抑郁评分呈负相关性，NPY和SP可能在伴焦虑抑郁情绪功能性消化不良发病机制中起重要作用。

关键词: 功能性消化不良, 神经肽Y, P物质, 焦虑, 抑郁

Objective

To investigate the correlation between plasma neuropeptide tyrosine (NPY) and substance P (SP) levels and anxiety and depression in patients with functional dyspepsia (FD).

Methods

Anxiety and depression scores of 30 patients with FD and 30 healthy volunteers were obtained by self-rating anxiety scale (SAS) and self-rating depression scale (SDS). The peripheral blood of participants was collected and the enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of plasma NPY and SP.

Results

The levels of NPY and SP were (94.82±18.53)ng/L and (35.16±8.42)ng/L in the FD group respectively, and were (118.53±22.29)ng/L and (47.65±11.06)ng/L in the healthy controls respectively, the differences were statistically significant (t=8.13, 7.04; P<0.01). SAS and SDS scores were (67.4±14.2) and (63.9±13.5) in the FD group respectively, and were (44.6±11.7) and (41.1±10.6) in the healthy controls respectively, the differences were statistically significant (t=12.44, 11.18; P<0.01). There were no significant differences in gender, age and disease duration between FD patients and FD patients with anxiety and depression(χ²=1.22, 0.56, 2.14; P>0.05). The plasma NPY levels in FD patients were negatively correlated with SAS and SDS scores (r=-0.70, -0.61; P<0.001). The plasma SP levels in FD patients were negatively correlated with SAS and SDS scores (r=-0.74, -0.56; P<0.01).

Conclusions

The levels of plasma NPY and SP in FD patients are reduced, and negatively correlated with anxiety and depression scores. SP and NPY may be involved in the pathogenesis of functional dyspepsia with anxiety and depression.

Key words: Functional dyspepsia, Neuropeptide Y, Substance P, Anxiety, Depression

表1 FD组和健康对照组NPY和SP水平比较(ng/L，±s)

组别	例数	NPY	SP
FD组	30	94.82±18.53	35.16± 8.42
健康对照组	30	118.53±22.29	47.65±11.06
t值	?	8.13	7.04
P值	?	<0.01	<0.01

表1 FD组和健康对照组NPY和SP水平比较(ng/L，±s)

组别	例数	NPY	SP
FD组	30	94.82±18.53	35.16± 8.42
健康对照组	30	118.53±22.29	47.65±11.06
t值	?	8.13	7.04
P值	?	<0.01	<0.01

表2 FD组和健康对照组焦虑抑郁评分比较(分，±s)

组别	例数	SAS	SDS
FD组	30	67.4±14.2	63.9±13.5
健康对照组	30	44.6±11.7	41.1±10.6
t值	?	12.48	11.18
P值	?	<0.01	<0.01

表2 FD组和健康对照组焦虑抑郁评分比较(分，±s)

组别	例数	SAS	SDS
FD组	30	67.4±14.2	63.9±13.5
健康对照组	30	44.6±11.7	41.1±10.6
t值	?	12.48	11.18
P值	?	<0.01	<0.01

表3 伴与不伴焦虑抑郁情绪FD患者的基本特征比较(例数)

变量		例数	FD患者	伴焦虑抑郁情绪FD患者	χ²值	P值
性别		?	?	?	1.22	>0.05
?	男	13	8	5	?	?
?	女	17	7	10	?	?
年龄(岁)		?	?	?	0.56	>0.05
?	≤40	12	5	7	?	?
?	>40	18	10	8	?	?
病程(月)		?	?	?	2.14	>0.05
?	≤12	16	10	6	?	?
?	>12	14	5	9	?	?

表3 伴与不伴焦虑抑郁情绪FD患者的基本特征比较(例数)

变量		例数	FD患者	伴焦虑抑郁情绪FD患者	χ²值	P值
性别		?	?	?	1.22	>0.05
?	男	13	8	5	?	?
?	女	17	7	10	?	?
年龄(岁)		?	?	?	0.56	>0.05
?	≤40	12	5	7	?	?
?	>40	18	10	8	?	?
病程(月)		?	?	?	2.14	>0.05
?	≤12	16	10	6	?	?
?	>12	14	5	9	?	?

[1]	Dai F,Liu Y,Shi H, et al.Association of genetic variants in GNβ3 with functional dyspepsia：a meta-analysis [J]. Dig Dis Sci, 2014, 59(8): 1823-1830.
[2]	Loyd RA,Mcclellan DA.Update on the evaluation and management of functional dyspepsia [J]. Am Fam Pgysician, 2011, 83(5): 547-552.
[3]	Miwa H,Kusano M,Arisawa T, et al.Evidence-based clinical practice guidelines for functional dyspepsia [J]. J Gastroenterol, 2015, 50(2): 125-139.
[4]	Holtmann G,Talley NJ.Functional dyspepsia [J]. Curr Opin Gastroen terol, 2015, 31(6): 492-498.
[5]	Nan J,Liu J,Mu J, et al.Brain-based correlations between psychological factors and functional dyspepsia [J]. J Neurogastroenterol Motil, 2015, 21(1): 103-110.
[6]	Vadnie CA,Park JH,Abdel Gawad N, et al.Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders [J]. Front Neurosci, 2014(8): 288.
[7]	Holzer P,Farzi A. Neuropeptides and the microbiota-gut-brain axis [J]. Adv Exp Med Biol, 2014(817): 195-219.
[8]	Koloski NA,Jones M,Kalantar JS, et al.Is it the brain-gut or the gut-brain that drives irritable bowel syndrome (IBS) and functional dyspepsia (FD)? [J]. Gastroenterology, 2011, 140(5): S-462.
[9]	李凯,赵卫星,鲍永华, 等. 胃炎、食管炎和食管癌患者血清中人丝氨酸蛋白酶8的表达及临床意义[J/CD]. 中华诊断学电子杂志, 2016(4): 45-47.
[10]	罗国刚,马玉青,苟静, 等. 偏头痛患者伴发焦虑/抑郁及功能残疾的临床研究[J]. 中国神经精神疾病杂志, 2012, 38(8): 477-481.
[11]	Huang ZP,Yang XF,Lan LS, et al.Correlation between social factors and anxiety-depression in function dyspepsia：do relationships exist？[J]. Prz Gastroenterol, 2014, 9(6): 348-353.
[12]	Mayer EA.Gut feelings：the emerging biology of gut-brain communication [J]. Nat Rev Neurosci, 2011, 12(8): 453-466.
[13]	Liu J,Li F,Tang XD, et al.XiangshaLiujunzi decoction alleviates the symptoms of functional dyspepsia by regulating brain-gut axis and production of neuropeptides [J]. BMC Complement Altern Med, 2015(15): 387.
[14]	Brothers SP,Wahlestedt C. Therapeutic potential of neuropeptide Y (NPY) receptor ligands [J]. EMBO Mol Med, 2010, 2(11): 429-439.
[15]	Vona-Davis LC,Mcfadden DW.NPY family of hormones：clinical relevance and potential use in gastrointestinal disease [J]. Curr Top Med Chem, 2007, 7(17): 1710-1720.
[16]	Holzer P,Reichmann F,Farzi A. Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis [J]. Neuropeptides, 2012, 46(6): 261-274.
[17]	El-Salhy M,Hausken T. The role of the neuropeptide Y (NPY) family in the pathophysiology of inflammatory bowel disease (IBD) [J]. Neuropeptides, 2016(55): 137-144.
[18]	Dey D,Abad J,Ray AP, et al.Differential temporal changes in brain and gut substance P mRNA expression throughout the time-course of cisplatin-induced vomiting in the least shrew (Cryptotis parva) [J]. Brain Res, 2010(1310): 103-112.
[19]	Czujkowska A,Arciszewski MB.Galanin is co-expressed with substance P, calbindin and corticotropin-releasing factor (CRF) in the enteric nervous system of the wild boar (sus scrofa) small intestine[J]. Anat Histol Embryol, 2016, 45(2): 115-123.
[20]	沈天华,沈洪,吴坚, 等. 半夏泻心汤对功能性消化不良大鼠模型血浆P物质及胃窦黏膜CGRP的影响[J]. 中华中医药杂志, 2011, 26(11): 2737-2739.

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