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中华诊断学电子杂志 ›› 2016, Vol. 04 ›› Issue (03) : 206 -209. doi: 10.3877/cma.j.issn.2095-655X.2016.03.015

所属专题: 文献

临床研究

miRNA-23a在扩张型心肌病中表达的意义
刘立新1, 张韶辉1, 魏广和1,(), 贾印峰2, 高荣华2, 蔺跃栋2, 高振才2, 陈安勇1   
  1. 1. 272029 济宁医学院附属医院心内三科;272029 济宁,山东省心脏疾病诊疗重点实验室
    2. 272029 济宁医学院附属医院心内三科
  • 收稿日期:2016-04-08 出版日期:2016-08-26
  • 通信作者: 魏广和
  • 基金资助:
    山东省医药卫生科技发展计划项目(2014WS0515); 济宁医学院附属医院"苗圃"科研项目(JYFY-MP-2013-MS-002)

Expression and significance of miRNA-23a in patients with dilated cardiomyopathy

Lixin Liu1, Shaohui Zhang1, Guanghe Wei1,(), Yinfeng Jia2, Ronghua Gao2, Yuedong Lin2, Zhencai Gao2, Anyong Chen1   

  1. 1. Department of Cardiology , Affiliated Hospital of Jining Medical University, Jining 272029, China; Shandong Provinicial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining 272029, China
    2. Department of Cardiology , Affiliated Hospital of Jining Medical University, Jining 272029, China
  • Received:2016-04-08 Published:2016-08-26
  • Corresponding author: Guanghe Wei
  • About author:
    Corresponging author: Wei Guanghe, Email:
引用本文:

刘立新, 张韶辉, 魏广和, 贾印峰, 高荣华, 蔺跃栋, 高振才, 陈安勇. miRNA-23a在扩张型心肌病中表达的意义[J/OL]. 中华诊断学电子杂志, 2016, 04(03): 206-209.

Lixin Liu, Shaohui Zhang, Guanghe Wei, Yinfeng Jia, Ronghua Gao, Yuedong Lin, Zhencai Gao, Anyong Chen. Expression and significance of miRNA-23a in patients with dilated cardiomyopathy[J/OL]. Chinese Journal of Diagnostics(Electronic Edition), 2016, 04(03): 206-209.

目的

观察miR-23a在扩张型心肌病(DCM)外周血中的表达差异,评估其临床意义。

方法

收集26例DCM患者作为病例组,收集30例健康者作为对照组。比较两组的临床资料和心脏超声结果,检测脑尿钠肽(BNP)等生化指标,用Real-time PCR检测和比较两组的miR-23a表达水平的差异,并通过ROC曲线分析评估miR-23a对DCM患者的识别能力。

结果

DCM组的BNP(605.00±231.71,26.29±17.88,t=218.61,P<0.05)、左室舒张末直径(LVEDD)高于对照组(64.73±5.74,45.58±2.17,t=6.09,P<0.05),左室射血分数(LVEF)低于对照组(35.33±4.31,58.72±3.35,t=-13.54,P<0.05)。miR-23a在DCM组中的表达量高于对照组(3.56±2.56,1.18±0.86,t=2.85,P<0.01),差异有统计学意义。ROC曲线分析发现,miR-23a对DCM患者具有一定的临床识别能力[AUC=0.781,95% CI(0.651,0.911),P<0.01]。

结论

miR-23a在DCM患者外周血中的表达明显升高,miR-23a可能在DCM患者中具有一定的临床诊断价值。

Objective

To observe the expression of miR-23a in dilated cardiomyopathy (DCM) of the peripheral blood and assess its clinical significance.

Methods

Twenty-six patients with dilated cardiomyopathy and 30 healthy controls were enrolled.The clinical data of the two groups, cardiac ultrasound, plasma level of brain natriuretic peptide (BNP) and other biochemical indicators were collected respectively.Real-time polymerase chain reaction (PCR) was used to detect and compare two groups′s miR-23a expression level differences, ROC curve analysis was used to assess miR-23a recognition in patients with DCM.

Results

BNP (605.00±231.71, 26.29±17.88, t=218.61, P<0.05) and left ventricular end-diastdic diameter (LVEDD) (64.73±5.74, 45.58±2.17, t=6.09, P<0.05) in DCM group were higher than those in control group, left ventricular ejection fraction (LVEF) lower than that in control group (35.33±4.31, 58.72±3.35, t=-13.54, P<0.05). miR-23a expression in the DCM group was higher than that in control group (33.56±2.56, 1.18±0.86, t=2.85, P<0.01), the difference was statistically significant.ROC curve analysis demonstrated that miR-23a had certain clinical recognition ability in patients with DCM [AUC=0.781, 95% CI(0.651, 0.911), P<0.01].

Conclusion

The expression of miR-23a elevated in the peripheral blood of patients with DCM, miR-23a may have certain clinical diagnostic value in patients with DCM.

表1 两组被试基线资料比较(±s)
图1 miR-23a对DCM的诊断能力评价
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