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中华诊断学电子杂志 ›› 2017, Vol. 05 ›› Issue (01) : 51 -54. doi: 10.3877/cma.j.issn.2095-655X.2017.01.014

所属专题: 文献

临床研究

青中年缺血性脑卒中患者血清抗心磷脂抗体免疫球蛋白G、白细胞介素-17、超敏C反应蛋白水平变化的意义
庄献博1, 王未飞1, 单广振1,(), 陈团芝1, 姜桂生1, 杨霞峰1   
  1. 1. 252000 聊城市人民医院神经内科
  • 收稿日期:2016-08-26 出版日期:2017-02-26
  • 通信作者: 单广振

The relationship between the serum ACA-IgG, IL-17 and hsCRP concentration and middle cerebral artery atherosclerotic stenosis of young adults

Xianbo Zhuang1, Weifei Wang1, Guangzhen Shan1,(), Tuanzhi Chen1, Guisheng Jiang1, Xiafeng Yang1   

  1. 1. Department of Neurology, Liaocheng People′s Hospital, Liaocheng 252000, China
  • Received:2016-08-26 Published:2017-02-26
  • Corresponding author: Guangzhen Shan
  • About author:
    Corresponding author: Shan Guangzhen, Email:
引用本文:

庄献博, 王未飞, 单广振, 陈团芝, 姜桂生, 杨霞峰. 青中年缺血性脑卒中患者血清抗心磷脂抗体免疫球蛋白G、白细胞介素-17、超敏C反应蛋白水平变化的意义[J]. 中华诊断学电子杂志, 2017, 05(01): 51-54.

Xianbo Zhuang, Weifei Wang, Guangzhen Shan, Tuanzhi Chen, Guisheng Jiang, Xiafeng Yang. The relationship between the serum ACA-IgG, IL-17 and hsCRP concentration and middle cerebral artery atherosclerotic stenosis of young adults[J]. Chinese Journal of Diagnostics(Electronic Edition), 2017, 05(01): 51-54.

目的

探讨青中年缺血性脑卒中患者血清抗心磷脂抗体免疫球蛋白G(ACA-IgG)、白细胞介素-17(IL-17)及超敏C反应蛋白(hsCRP)水平与大脑中动脉狭窄程度的关系。

方法

对78例缺血性脑卒中患者行数字减影全脑血管造影(DSA),根据DSA结果将患者分为无狭窄组(21例)、轻度狭窄组(22例)、中度狭窄组(18例)和重度狭窄组(17例),检测比较各组血清ACA-IgG、IL-17、hsCRP水平。

结果

无狭窄组及轻、中、重度狭窄组血清ACA-IgG水平分别为(25.53±6.23)kU/L、(36.14±6.67)kU/L、(47.75±8.31)kU/L、(62.41±11.26)kU/L,血清IL-17水平分别为(35.54±11.32)ng/L、(57.62±19.06)ng/L、(64.05±28.67)ng/L、(78.36±25.01)ng/L,血清hsCRP水平分别为(2.06±1.53)mg/L、(4.23±1.17)mg/L、(5.30±1.34)mg/L、(6.72±2.01)mg/L;大脑中动脉轻、中、重度狭窄组血清ACA-IgG、IL-17水平显著增高(F=15.36,10.16,9.58;P<0.05);Logistic回归分析显示,血清ACA-IgG及IL-17水平增高预测颅内动脉狭窄的比值比(OR)为1.624和1.235。

结论

ACA-IgG、IL-17在青中年大脑中动脉粥样硬化性狭窄的发生和发展过程中可能起重要作用。

Objective

To explore the relationship between the serum anticardiolipin antibody-immune globulin G (ACA-IgG), interleukin-17 (IL-17) and high-sensitivity C-reactive protein (hsCRP) concentration and intracerebral artery stenosis middle cerebral artery atherosclerotic stenosis.

Methods

By digital subtraction angiography (DSA), 78 patients with ischemic cerebrovascular disease were enrolled and divided into a stenosis-free group(21 cases), mild-stenosis group (n=22), moderate-stenosis group (n=18), and severe-stenosis group (n=17). The level of serum ACA-IgG, IL-17 and hsCRP were detected.

Results

The levels of serum ACA-IgG in the stenosis-free group, mild, moderate and severe stenosis groups were (25.53±6.23)kU/L, (36.14±6.67)kU/L, (47.75±8.31)kU/L and (62.41±11.26)kU/L respectively.The levels of serum IL-17 were (35.54±11.32)ng/L, (57.62±19.06)ng/L, (64.05±28.67)ng/L and (78.36±25.01)ng/L respectively.The level of serum hsCRP were (2.06±1.53)mg/L, (4.23±1.17)mg/L, (5.30±1.34)mg/L and (6.72±2.01)mg/L respectively.Compared with stenosis-free group, the levels of serum ACA-IgG and IL-17 were significantly increased in the mild, moderate and severe stenosis groups(all P<0.05). Logistic regression analysis showed that the odds ratio (OR) of hyper ACA-IgG and IL-17 for intracerebral artery stenosis were 1.624 and 1.235, respectively.

Conclusion

ACA-IgG and IL-17 may play an important role in middle cerebral artery atherosclerotic stenosis of young adult.

表1 大脑中动脉不同程度狭窄缺血性卒中患者相关危险因素比较(例,%)
表2 大脑中动脉不同程度狭窄缺血性卒中患者血清ACA-IgG、IL-10、IL-17水平比较(±s)
表3 影响大脑中动脉狭窄的多因素Logistic回归分析
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