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中华诊断学电子杂志 ›› 2017, Vol. 05 ›› Issue (02) : 120 -123. doi: 10.3877/cma.j.issn.2095-655X.2017.02.011

所属专题: 文献

临床研究

成人原发性癫痫患者血清酰基化ghrelin和nesfatin-1水平变化的意义
夏敏1, 刘栋1, 王艳玲1, 褚旭1, 孔庆霞1,()   
  1. 1. 272029 济宁医学院附属医院神经内四科
  • 收稿日期:2016-12-13 出版日期:2017-05-26
  • 通信作者: 孔庆霞
  • 基金资助:
    国家自然科学基金(81371423); 济宁医学院青年基金(JYQ2011KM060)

Diagnostic value of serum levels of acylated ghrelin and nesfatin-1 in adult patients with primary epilepsy

Min Xia1, Dong Liu1, Yanling Wang1, Xu Chu1, Qingxia Kong1,()   

  1. 1. Department of Neurology, Affiliated Hospital of Jining Medical University, Jining 272029, China
  • Received:2016-12-13 Published:2017-05-26
  • Corresponding author: Qingxia Kong
  • About author:
    Corresponding author: Kong Qingxia, Email:
引用本文:

夏敏, 刘栋, 王艳玲, 褚旭, 孔庆霞. 成人原发性癫痫患者血清酰基化ghrelin和nesfatin-1水平变化的意义[J]. 中华诊断学电子杂志, 2017, 05(02): 120-123.

Min Xia, Dong Liu, Yanling Wang, Xu Chu, Qingxia Kong. Diagnostic value of serum levels of acylated ghrelin and nesfatin-1 in adult patients with primary epilepsy[J]. Chinese Journal of Diagnostics(Electronic Edition), 2017, 05(02): 120-123.

目的

探讨成人原发性癫痫患者治疗前与卡马西平(CBZ)、丙戊酸钠(VPA)治疗6个月后血清酰基化ghrelin(AG)和nesfatin-1水平变化的意义。

方法

选取2013年2月至2015年2月济宁医学院附属医院神经内科收治的成人原发性癫痫患者,共50例,其中30例为部分性发作继发全面性发作(SGE),20例为原发性全面性发作(PGE)。分别给予CBZ、VPA治疗6个月,于治疗前和药物治疗后用酶联免疫吸附法测定血清AG和nesfatin-1水平。

结果

SGE组治疗前血清AG水平[(32.67±5.64) ng/L]低于对照组[(42.49±8.24)ng/L](t=2.08,P<0.05),CBZ治疗6个月后AG水平[(54.31±7.91)ng/L]较治疗前增高(t=2.80,P<0.05)。PGE组治疗前血清AG水平[(31.56±6.32)ng/L]低于对照组(t=2.09,P<0.05),VPA治疗6个月后血清AG水平[(51.37±7.56)ng/L]较治疗前增高(t=3.22,P<0.05)。SGE组治疗前血清nesfatin-1水平[(6.57±0.93)μg/L]高于对照组[(0.66±0.02)μg/L](t=2.18,P<0.05),CBZ治疗6个月后nesfatin-1水平[(2.74±0.56)μg/L]较对照组仍升高(t=2.05,P<0.05)。PGE组治疗前血清nesfatin-1水平[(9.04±1.32)μg/L]较对照组升高(t=3.83,P<0.05),VPA治疗6个月后血清nesfatin-1水平[(3.28±0.43)μg/L]较对照组仍升高(t=2.24,P<0.05)。

结论

血清AG水平高可能有抗癫痫和神经保护作用,nesfatin-1可能作为癫痫诊断的生物标记物。

Objective

To study the serum levels of acylated ghrelin(AG)and nesfatin-1 in adult patients with primary epilepsy in the pretreatment period and six months after carbamazepine (CBZ) or valproic acid(VPA) therapy.

Methods

Fifty adult patients with primary epilepsy [30 with secondary generalized epilepsy (SGE), 20 with primary generalized epilepsy (PGE)] and 20 control patients were included in this study.Serum levels of AG and nesfatin-1 were measured in these groups in the pretreatment period and six months after treatment.

Results

Serum level of AG in control group was (42.49±8.24) ng/L, pretherapy serum level of AG in SGE (32.67±5.64)ng/L was lower than that in control group (t=2.08, P<0.05). Post-CBZ therapy serum level of AG (54.31±7.91)ng/L was higher than that in pretherapy (t=2.80, P<0.05). Pretherapy serum level of AG in PGE (31.56±6.32)ng/L was lower than that in control group(t=2.09, P<0.05), post-VPA therapy serum level of AG (51.37±7.56)ng/L was higher than that in pretherapy(t=3.22, P<0.05). Serum level of nesfatin-1 in control group was (0.66±0.02)μg/L.Pretherapy serum level of nesfatin-1 in SGE [(6.57±0.93)μg/L] was higher than that in control group(t=2.18, P<0.05), post-CBZ therapy serum level of nesfatin-1 [(2.74±0.56)μg/L] was also higher than that in control group(t=2.05, P<0.05). Pretherapy serum level of nesfatin-1 in PGE (9.04±1.32)μg/L was higher than that in control group (t=3.83, P<0.05), post-VPA therapy serum level of nesfatin-1(3.28±0.43)μg/L was also higher than that in control group (t=2.24, P<0.05).

Conclusion

AG may have protective effects on neurons and have antiepilepsy effects, nesfatin-1 may serve as biomarker for the diagnosis of primary epilepsy.

表1 各组患者治疗前一般情况比较(±s)
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