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中华诊断学电子杂志 ›› 2017, Vol. 05 ›› Issue (03) : 213 -215. doi: 10.3877/cma.j.issn.2095-655X.2017.03.018

所属专题: 文献

综述

生物标志物在气道炎症及重塑诊治中的应用
郭凯1, 施建元1, 顾雪明1, 汤正义2, 殷少军3,()   
  1. 1. 200031 上海交通大学医学院附属瑞金医院远洋分院内科
    2. 200025 上海交通大学医学院附属瑞金医院内分泌代谢病科
    3. 201306 上海交通大学附属第六人民医院东院呼吸内科
  • 收稿日期:2017-03-16 出版日期:2017-08-26
  • 通信作者: 殷少军
  • 基金资助:
    上海申康医院发展中心郊区三级医院临床能力建设项目(SHDC12013901)

The application of biological markers in the diagnosis and treatment of airway inflammation and remodeling

Kai Guo1, Jianyuan Shi1, Xueming Gu1, Zhengyi Tang2, Shaojun Yin3,()   

  1. 1. Department of Internal Medicine, Yuanyang Branch of Shanghai Ruijin Hospital, Shanghai 200031, China
    2. Department of Endocrinology and Metabolism Medicine, Shanghai Ruijin Hospital, Shanghai 200025, China
    3. Department of Respiratory Medicine, Shanghai Six People’s Hospital, Shanghai 200031, China
  • Received:2017-03-16 Published:2017-08-26
  • Corresponding author: Shaojun Yin
  • About author:
    Corresponding author: Yin Shaojun, Email:
引用本文:

郭凯, 施建元, 顾雪明, 汤正义, 殷少军. 生物标志物在气道炎症及重塑诊治中的应用[J]. 中华诊断学电子杂志, 2017, 05(03): 213-215.

Kai Guo, Jianyuan Shi, Xueming Gu, Zhengyi Tang, Shaojun Yin. The application of biological markers in the diagnosis and treatment of airway inflammation and remodeling[J]. Chinese Journal of Diagnostics(Electronic Edition), 2017, 05(03): 213-215.

气道炎症及重塑是许多慢性肺部疾病共有的病理生理基础,由于涉及多种炎症细胞、细胞组分及炎性介质的相互作用,致使其病理生理机制及临床表现均存在一定的异质性,单一指标难以全面反映气道炎症及重塑的水平和预后情况。由于支气管哮喘、慢性阻塞性肺疾病和肺动脉高压有着共同的气道炎症及重塑通路,因此笔者从这几个方面对当前已应用于临床以及正处于研究当中的能够反映气道炎症水平和气道重塑的生物标志物进行讨论,以期有助于慢性肺部疾病中气道炎症及重塑的临床评估,为治疗选择提供更多参考。

The airway inflammation and remodeling is the pathophysiological basis of many common chronic lung diseases.It is difficult that the single indicator fully reflects the level and prognosis airway inflammation and remodeling.Because it involves the interaction of a variety of inflammatory cells, cellular components and inflammatory mediators, which can result in the certain heterogeneity of pathophysiology and clinical manifestations.This review focuse don asthma, chronic obstructive pulmonary disease, pulmonary hypertension and discusses biomarkers that has been researched for their usefulness to phenotype chronic inflammatory lung diseases which cause remodeling of the lung′s architecture.The goal is to evaluate the airway inflammation and remodeling during the chronic lung disease and to provide more treatment options for reference.

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