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中华诊断学电子杂志 ›› 2017, Vol. 05 ›› Issue (04) : 235 -239. doi: 10.3877/cma.j.issn.2095-655X.2017.04.005

所属专题: 文献

心脑血管疾病诊治

动脉钙化发生机制的研究进展
张雪1, 孟强2, 孙琳2,()   
  1. 1. 272067 济宁医学院
    2. 272029 济宁医学院附属医院内分泌科
  • 收稿日期:2017-05-05 出版日期:2017-11-26
  • 通信作者: 孙琳
  • 基金资助:
    山东省自然科学基金联合专项计划(ZR2014HL031)

The research progress of the mechanism of arterial calcification

Xue Zhang1, Qiang Meng2, Lin Sun2,()   

  1. 1. Jining Medical University, Jining 272067, China
    2. Department of Endocrinology, the Affiliated Hospital of Jining Medical University, Jinning 272029, China
  • Received:2017-05-05 Published:2017-11-26
  • Corresponding author: Lin Sun
  • About author:
    Corresponding author: Sun Lin, Email:
引用本文:

张雪, 孟强, 孙琳. 动脉钙化发生机制的研究进展[J/OL]. 中华诊断学电子杂志, 2017, 05(04): 235-239.

Xue Zhang, Qiang Meng, Lin Sun. The research progress of the mechanism of arterial calcification[J/OL]. Chinese Journal of Diagnostics(Electronic Edition), 2017, 05(04): 235-239.

动脉钙化常见于动脉粥样硬化、糖尿病、老年人及慢性肾脏病患者,是导致心血管疾病发生发展和致死的重要原因。目前认为,动脉钙化是一种类似于骨形成的主动调控过程,其中血管平滑肌细胞(VSMCs)是动脉钙化的细胞学基础。然而,动脉钙化的确切机制尚不清楚,多种因素如C反应蛋白(CRP)、骨形成蛋白(BMPs)、核苷酸结合寡聚化结构域样受体3(NLRP3)以及骨保护素(OPG)等都影响其进程。笔者简要综述了炎症、细胞因子和相关免疫与动脉钙化的关系。

Vascular calcification is prevalent in patients with atherosclerosis, old age, diabetes mellitus, and chronic kidney diseases.It is highly associated with increased morbidity and mortality of cardiovascular diseases.At present, arterial calcification is a kind of active regulation process similar to bone formation, in which vascular smooth muscle cells are the cytological basis.However, the exact mechanism of arterial calcification is not clear, a variety of factors such as C-reactive protein, bone morphogenetic proteins, NLRP3 inflammatory body and osteoprotegerin and so on can affect its progress.This paper briefly reviews the relationship among inflammation, cytokines and related immunity with arterial calcification.

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