| [1] |
Yilmaz U．Alzheimer′s disease[J]．Radioloqe，2015，55(5):386-388.
|
| [2] |
宋昕，洪羽蓉，胡秋莹. 阿尔兹海默病发病原因及机制的研究进展[J]．临床和实验医学杂志，2015, 14(10):871-873.
|
| [3] |
Wang JZ, Gong CX, Zaidi T，et al.Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B[J]．J Biol Chem，1995，270(9):4854-4860.
|
| [4] |
陈杨剑侠，柯尊记．自噬在阿尔兹海默病防治中的作用[J]．饮食保健，2018，5(7):296-297.
|
| [5] |
Wenk GL.Neuropathologic changes in Alzheimer′s disease[J]．J Clin Psychiatry，2003，64(Suppl9):7-10.
|
| [6] |
Sjögren M, Davidsson P, Gottfries J，et al. The cerebrospinal fluid levels of tau，growth-associated protein-43 and soluble amyloid precursor protein correlate in Alzheimer′s disease，reflecting a common pathophysiological process[J]. Dement Geriatr Cogn Disord，2001，12(4):257-264.
|
| [7] |
Neve RL, Harris P, Kosik KS，et al.Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2[J]．Brain Res，1986，387(3):271-280.
|
| [8] |
Goedert M, Rutherford RD, Crowther RA.Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2[J]．Neuron，1989(3):519-526.
|
| [9] |
Scott CW, Blowers DP, Barth PT，et al.Differences in the abilities of human tau isoforms to promote microtubule assembly[J]．Neurosci Res，1991，30(1):154-162.
|
| [10] |
Trinczek B, Biernat J, Baumann K，et al.Domains of tau protein，differential phosphorylation，and dynamic instability of microtubules[J]．Mol Biol Cell，1995，6(12):1887-1902.
|
| [11] |
Kins S, Kurosinski P, Nitsch RM，et al.Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice[J]．Am J Pathol，2003，163(3):833-843.
|
| [12] |
An WL, Cowburn RF, Li L，et al.Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer′s disease[J]．Am J Pathol，2003，163(2):591-607.
|
| [13] |
Spillantini MG, Murrell JR, Goedert M，et al.Mutation in the tau gene in familial multiple system tauopathy with presenile dementia[J]．Proc Natl Acad Sci USA，1998，95(13):7737-7741.
|
| [14] |
Jadhav S, Cubinkova V, Zimova I，et al.Tau-mediated synaptic damage in Alzheimer′s disease[J]. Transl Neurosci，2015，6(1):214-226.
|
| [15] |
Sontag E, Nunbhakdi-Craig V, Lee G，et al.Molecular interactions among protein phosphatase 2A, tau, and microtubules.Implications for the regulation of tau phosphorylation and the development of tauopathies[J]．J Biol Chem，1999，274(36):25490-25498.
|
| [16] |
Davidsson P, Sjögren M. The use of proteomics in biomarker discovery in neurodegenerative diseases[J]．Dis Markers，2005，21(2):81-92.
|
| [17] |
Huang HC, Jiang ZF.Accumulated amyloid-β peptide and hyperphosphorylated tau protein：relationship and links in alzheimer′s disease[J]．J Alzheimers Dis，2009，16(1):15-27.
|
| [18] |
Hardy JA, Higgins GA.Alzheimer′s disease：the amyloid cascade hypothesis[J]．Science，1992，256(5054):184-185.
|
| [19] |
Blennow K, Mattsson N, Schöll M，et al.Amyloid biomarkers in Alzheimer′s disease[J]．Trends Pharmacol Sci，2015，36(5):297-309.
|
| [20] |
Tamaoka A. The pathophysiology of Alzheimer′s disease with special reference to "amyloid cascade hypothesis" [J]．Rinsho Byori，2013，61(11):1060-1069.
|
| [21] |
Luo J, Wärmländer SK, Gräslund A, et al. Alzheimer peptides aggregate into transient nanoglobules that nucleate fibrils[J]．Biochemistry，2014，53(40):6302-6308.
|
| [22] |
冯利杰，张瑾，丁倩，等．自噬参与神经细胞中过表达tau和异常磷酸化tau蛋白的降解[J]．中国药理学通报，2015，31(3):356-362.
|
| [23] |
Klionsky DJ, Abdelmohsen K, Abe A，et al.Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)[J]．Autophagy，2016，12(1):1-222.
|
| [24] |
Friedman LG, Qureshi YH, Yu WH.Promoting autophagic clearance：viable therapeutic targets in alzheimer′s disease[J]．Neurotherapeutics，2015，12(1):94-108.
|
| [25] |
Nilsson P, Saido TC. Dual roles for autophagy: degradation and secretion of Alzheimer′s disease Aβ peptide[J]．Bioessays，2014，36(6):570-578.
|
| [26] |
Jewell JL, Russell RC, Guan KL.Amino acid signalling upstream of mTOR[J] .Nat Rev Mol Cell Biol，2013，14(3):133-139.
|
| [27] |
Nilsson P, Saido TC. Dual roles for autophagy：degradation and secretion of Alzheimer′s disease Aβ peptide [J]．BioEssays，2014，36(6):570-578.
|
| [28] |
Steele JW, Lachenmayer ML, Ju S, et al. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer′s mouse model[J]．Mol Psychiatry，2013，18(8):889-897.
|
| [29] |
Sweetlove M．Phase Ⅲ concert trial of latrepirdine[J] .Pharmaceut Med，2012，26(2):113-115.
|
| [30] |
Zhu Z, Yan J, Jiang W，et al.Arctigenin effectively ameliorates memory impairment in Alzheimer′s disease model mice targeting both β-Amyloid production and clearance[J]．J Neurosci，2013，33(32):13138-13149.
|
| [31] |
Darlington D, Deng J, Giunta B，et al.Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-β-associated neuropathology in Alzheimer mice[J]．Stem Cells Dev，2012，22(3):412-421.
|
| [32] |
Kirkin V, McEwan DG, Novak I，et al.A role for ubiquitin in selective autophagy[J]．Mol cell，2009，34(3):259-269.
|
| [33] |
李伟，肖世富．阿尔茨海默病诊断标准的演变及评价[J/CD]．中华诊断学电子杂志，2015，3(2):114-117.
|