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中华诊断学电子杂志 ›› 2019, Vol. 07 ›› Issue (02) : 141 -144. doi: 10.3877/cma.j.issn.2095-655X.2019.02.015

所属专题: 文献

综述

肝细胞癌临床诊断及其适配体应用的研究现状
陈意飞1, 夏伟2, 顾晨3, 杨生妹3,()   
  1. 1. 225007 扬州大学附属医院急诊医学科
    2. 225007 扬州大学附属医院肝胆胰外科
    3. 225009 扬州大学生物科学与技术学院生物化学系
  • 收稿日期:2019-01-04 出版日期:2019-05-26
  • 通信作者: 杨生妹
  • 基金资助:
    扬州市十三五科教强卫工程(ZDRC2018016)

Research of diagnosis and application of Aptamer in hepatocellular carcinoma

Yifei Chen1, Wei Xia2, Chen Gu3, Shengmei Yang3,()   

  1. 1. Department of Emergency, the Affiliated Hospital of Yangzhou University, Yangzhou 225002, China
    2. Department of Hepatobilliary Surgery, the Affiliated Hospital of Yangzhou University, Yangzhou 225002, China
    3. Department of Biochemistry, College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, China
  • Received:2019-01-04 Published:2019-05-26
  • Corresponding author: Shengmei Yang
  • About author:
    Corresponding author: Yang Shengmei, Email:
引用本文:

陈意飞, 夏伟, 顾晨, 杨生妹. 肝细胞癌临床诊断及其适配体应用的研究现状[J]. 中华诊断学电子杂志, 2019, 07(02): 141-144.

Yifei Chen, Wei Xia, Chen Gu, Shengmei Yang. Research of diagnosis and application of Aptamer in hepatocellular carcinoma[J]. Chinese Journal of Diagnostics(Electronic Edition), 2019, 07(02): 141-144.

肝细胞癌是临床上最常见的消化系统恶性肿瘤之一,是导致癌症相关死亡的第二大病因。肝细胞癌的发生机制比较复杂,临床治疗手段有限,预后不佳。适配体的筛选和建立,可用于分子生物学细胞检测、影像分析以及靶向治疗,是肝细胞癌诊治新的希望。适配体相关研究从肝细胞癌细胞的检测、分子标志物检测出发,形成了良好的开端,为进一步实现干扰信号通路、介导基因、靶向治疗,提供了新的方向。本综述兼顾了肝细胞癌的临床诊断现状,重点阐述了适配体技术原理及其在肝细胞癌诊断中的研究进展。

Hepatocellular carcinoma (HCC) is one of the most common malignancies in digestive system and the second leading cause of cancer-related death. It has complicated pathogenesis, limited clinical treatments and poor prognosis. The screening and establishment of Aptamers can be used for molecular biological cell detection, image analysis and targeted therapy so as to be a new hope for the diagnosis and treatment of hepatocellular carcinoma. Relevant studies have made a good start from the detection of hepatocellular carcinoma cells and molecular markers, providing a new direction for the further progression of interfering signal pathways, mediating genes and targeted therapy.This review concentrates on the clinical diagnosis of hepatocellular carcinoma, the principle of Aptamer experiment and its progress in the diagnosis of hepatocellular carcinoma.

图1 指数富集法进化系统原理示意图
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