切换至 "中华医学电子期刊资源库"

中华诊断学电子杂志 ›› 2019, Vol. 07 ›› Issue (03) : 147 -150. doi: 10.3877/cma.j.issn.2095-655X.2019.03.002

所属专题: 文献

肿瘤心脏病诊治

抗肿瘤治疗所致心脏毒性的研究进展
孙星星1, 闵大六1,()   
  1. 1. 201306 上海交通大学附属第六人民医院肿瘤内科
  • 收稿日期:2018-10-29 出版日期:2019-08-26
  • 通信作者: 闵大六
  • 基金资助:
    上海市卫生和计划生育委员会卫生行业临床研究专项面上项目(201840039); 上海健康医学院种子基金项目国家级项目培育专项(SFP-18-20-14-002); 2019上海市科委自然科学基金(19ZR1439100)

Research progress of antitumor treatment-induced cardiotoxicity

Xingxing Sun1, Daliu Min1,()   

  1. 1. Department of Medical Oncology, Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 201306, China
  • Received:2018-10-29 Published:2019-08-26
  • Corresponding author: Daliu Min
  • About author:
    Corresponding author: Min Daliu, Email:
引用本文:

孙星星, 闵大六. 抗肿瘤治疗所致心脏毒性的研究进展[J]. 中华诊断学电子杂志, 2019, 07(03): 147-150.

Xingxing Sun, Daliu Min. Research progress of antitumor treatment-induced cardiotoxicity[J]. Chinese Journal of Diagnostics(Electronic Edition), 2019, 07(03): 147-150.

随着肿瘤治疗手段的进展,肿瘤患者的生存时间与生存质量得到了极大的改善,与此同时,细胞毒类药物及靶向治疗等新型抗肿瘤治疗所导致的心血管事件也与日俱增,并且影响着肿瘤患者的生存率与死亡率,由此引起了越来越多学者的关注。在此基础上,肿瘤心脏病学应运而生,其是一门旨在研究肿瘤患者心脏病诊断与治疗的新兴学科,其中抗肿瘤治疗所致心脏疾病是研究重点。笔者主要对抗肿瘤治疗所致心脏毒性的最新研究进展作一综述。

With the improvement of cancer therapy, the survival time and quality of life of patients have been greatly improved. However, in the meanwhile, the cardiovascular events caused by cytotoxic drugs and targeted therapy are increasing day by day, and affecting the survival and mortality of cancer patients. This attracts more and more attention. On the basis of above, onco-cardiology comes into being which aims to study the diagnosis and treatment of heart disease in cancer patients. The heart disease caused by anti-tumor treatment is the focus of onco-cardiology research. Here, we review the latest advances in the research progress of antitumor treatment-induced cardiotoxicity.

[1]
李涌平,韩丽媛.流行病学转变视角下中国死亡水平及死因构成分析:2009-2013[J].人口与发展,2016,22(3):36-42.
[2]
Mukai M, Komori K, Oka T.Mechanism and management of cancer chemotherapy-induced atherosclerosis[J].J Atheroscler Thromb,2018,25(10):994-1002.
[3]
钟久昌.肿瘤心脏病学科的过去、现在与将来—机遇和挑战[J].药学进展,2018,42(7):481-482.
[4]
Zamorano JL, Lancellotti P, Muñoz DR,et al.2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines[J].Kardiol Pol,2016,74(11):1193-1233.
[5]
Koutsoukis A, Ntalianis A, Repasos E,et al.Cardio-oncology:a focus on cardiotoxicity[J].Eur Cardiol,2018,13(1):64-69.
[6]
Suter TM, Ewer MS.Cancer drugs and the heart:importance and management[J].Eur Heart J,2013,34(15):1102-1111.
[7]
Corremans R, Adão R, De Keulenaer GW,et al.Update on pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity[J].Clin Exp Pharmacol Physiol,2019,46(3):204-215.
[8]
McGowan JV, Chung R, Maulik A,et al.Anthracycline chemotherapy and cardiotoxicity[J].Cardiovasc Drugs Ther,2017,31(1):63-75.
[9]
Hanahan D, Weinberg Robert A.Hallmarks of Cancer:the next generation[J].Cell,2011,144(5):646-674.
[10]
Touyz RM, Herrmann J. Cardiotoxicity with vascular endothelial growth factor inhibitor therapy[J].NPJ Precis Oncol,2018(2):13.
[11]
Takada M, Yasui T, Oka T, et al. Aortic dissection and cardiac dysfunction emerged coincidentally during the long-term treatment with angiogenesis inhibitors for metastatic renal cell carcinoma[J].Int Heart J,2018,59(5):1174-1179.
[12]
Nabialek-Trojanowska I, Lewicka E, Wrona A,et al.Cardiovascular complications after radiotherapy[J].Cardiol J,2018.[Epub ahead of print]
[13]
Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer[J].N Engl J Med,2013,368(11):987-998.
[14]
Menezes KM, Wang H, Hada M,et al.Radiation matters of the heart:a mini review[J].Front Cardiovasc Med,2018(5):83.
[15]
van den Bogaard VA, Ta BD, van der Schaaf A,et al.Validation and modification of a prediction model for acute cardiac events in patients with breast cancer treated with radiotherapy based on three-dimensional dose distributions to cardiac substructures[J].J Clin Oncol,2017,35(11):1171-1178.
[16]
Zhu Q, Kirova YM, Cao L, et al. Cardiotoxicity associated with radiotherapy in breast cancer:a question-based review with current literatures[J].Cancer Treat Rev,2018(68):9-15.
[17]
Mehta LS, Watson KE, Barac A,et al.Cardiovascular disease and breast cancer:where these entities intersect:a scientific statement from the american heart association[J].Circulation,2018,137(8):e30-e66.
[18]
Ichikawa Y, Ghanefar M, Bayeva M,et al.Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation[J].J Clin Invest,2014,124(2):617-630.
[19]
Levick SP, Soto-Pantoja DR, Bi J, et al. Doxorubicin-induced myocardial fibrosis involves the neurokinin-1 receptor and direct effects on cardiac fibroblasts[J].Heart Lung Circ,2018.[Epub ahead of print]
[20]
Mohan N, Jiang J, Dokmanovic M, et al.Trastuzumab-mediated cardiotoxicity:current understanding,challenges,and frontiers[J].Antibody Therapeutics,2018,1(1):13-17.
[21]
Costa I, Hajjar LA.What is the role of two-dimensional speckle tracking echocardiography in the diagnosis and management of anthracycline-induced cardiotoxicity?[J].Arq Bras Cardiol,2018,110(3):229-230.
[22]
宋飞艳,程蕾蕾,陈永乐.实时三维超声心动图评价淋巴瘤患者蒽环类药物化疗后左心室亚临床功能的价值[J/CD].中华诊断学电子杂志,2015,3(3):155-158.
[23]
Laufer-Perl M, Derakhshesh M, Milwidsky A,et al.Usefulness of global longitudinal strain for early identification of subclinical left ventricular dysfunction in patients with active cancer[J].Am J Cardiol,2018,122(10):1784-1789.
[24]
Simões R, Silva LM, Cruz ALVM,et al.Troponin as a cardiotoxicity marker in breast cancer patients receiving anthracycline-based chemotherapy:a narrative review[J].Biomed Pharmacother,2018(107):989-996.
[25]
Menna P, Salvatorelli E.Primary prevention strategies for anthracycline cardiotoxicity:a brief overview[J].Chemotherapy,2017,62(3):159-168.
[26]
Janbabai G, Nabati M, Faghihinia M,et al.Effect of enalapril on preventing anthracycline-induced cardiomyopathy[J].Cardiovasc Toxicol,2017,17(2):130-139.
[27]
Chotenimitkhun R, D′Agostino R Jr, Lawrence JA,et al.Chronic statin administration may attenuate early anthracycline-associated declines in left ventricular ejection function[J].Can J Cardiol,2015,31(3):302-307.
[28]
Kaya MG, Ozkan M, Gunebakmaz O,et al.Protective effects of nebivolol against anthracycline-induced cardiomyopathy:a randomized control study[J].Int J Cardiol,2013,167(5):2306-2310.
[29]
Franco YL, Vaidya TR, Ait-Oudhia S. Anticancer and cardio-protective effects of liposomal doxorubicin in the treatment of breast cancer[J].Breast Cancer (Dove Med Press),2018(10):131-141.
[30]
Veena RK, Ajith TA, Janardhanan KK.Lingzhi or Reishi medicinal mushroom,ganoderma iucidum (agaricomycetes),prevents doxorubicin-induced cardiotoxicity in rats[J].Int J Med Mushrooms,2018,20(8):761-774.
[31]
Song R, Yang Y, Lei H,et al.HDAC6 inhibition protects cardiomyocytes against doxorubicin-induced acute damage by improving alpha-tubulin acetylation[J].J Mol Cell Cardiol,2018(124):58-69.
[32]
Kheiri B, Abdalla A, Osman M,et al.Meta-analysis of carvedilol for the prevention of anthracycline-induced cardiotoxicity[J].Am J Cardiol,2018,122(11):1959-1964.
[33]
Piroth MD, Baumann R, Budach W,et al.Heart toxicity from breast cancer radiotherapy:current findings,assessment,and prevention[J].Strahlenther Onkol,2019,195(1):1-12.
[1] 梁梦婕, 金怡, 郑哲岚. 超声二维斑点追踪技术在蒽环类化疗药物心脏毒性监测中的应用价值[J]. 中华医学超声杂志(电子版), 2019, 16(10): 749-755.
[2] 李丹, 刘辉. 妇科腹腔镜手术并发症的特点及预防治疗措施[J]. 中华妇幼临床医学杂志(电子版), 2017, 13(05): 596-600.
[3] 汤栩文, 谢晓斌, 林斯. 血管内皮生长因子及其受体与可溶性血管内皮生长因子受体-1对妊娠期糖尿病与围生儿结局的预测价值[J]. 中华妇幼临床医学杂志(电子版), 2013, 09(01): 22-26.
[4] 房文通, 顾艳宏. 伴有合并症的结直肠癌治疗的药物选择[J]. 中华结直肠疾病电子杂志, 2018, 07(05): 420-430.
[5] 刘刚, 李佳琪, 胡冬梅, 郑立诚, 弋卓君, 臧永辉, 王春艳, 康斌, 石波, 唐诗添. 关节镜技术治疗原发性肘关节骨关节炎术后残余症状分析和预防措施[J]. 中华肩肘外科电子杂志, 2020, 08(02): 162-168.
[6] 金璿, 白羽, 吴世凯. 氟尿嘧啶联合紫杉类或铂类药物治疗进展期胃癌的心脏毒性研究[J]. 中华临床医师杂志(电子版), 2019, 13(05): 343-351.
[7] 马英东, 龚东, 李凌. 急性心肌梗死患者医院感染影响因素分析及其预防措施[J]. 中华介入放射学电子杂志, 2017, 05(02): 109-111.
[8] 戚厚兴, 崔芬. 加强多学科合作促进肿瘤心脏病学研究[J]. 中华诊断学电子杂志, 2019, 07(03): 145-146.
[9] 蔡宾, 彭斌. 脑出血血肿扩大的研究进展[J]. 中华脑血管病杂志(电子版), 2021, 15(02): 77-82.
阅读次数
全文


摘要