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中华诊断学电子杂志 ›› 2020, Vol. 08 ›› Issue (03) : 145 -149. doi: 10.3877/cma.j.issn.2095-655X.2020.03.001

所属专题: 文献

特殊环境战创伤诊治

脑冲击伤诊治的研究现状
刘媛1,(), 龙在云1, 李森1, 王海燕1, 杨策1   
  1. 1. 400042 重庆,陆军军医大学大坪医院野战外科研究部 创伤烧伤与复合伤国家重点实验室
  • 收稿日期:2020-01-16 出版日期:2020-08-26
  • 通信作者: 刘媛
  • 基金资助:
    军队青年培育项目资助(16QNP105); "十三五"军队"双重"建设科研创新项目(2019); 陆军特色医学中心人才创新能力培养计划(2019CXJSB007)

The research status of diagnosis and treatment of blast traumatic brain injury

Yuan Liu1,(), Zaiyun Long1, Sen Li1, Haiyan Wang1, Ce Yang1   

  1. 1. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital of Army Medical University, Chongqing 400042, China
  • Received:2020-01-16 Published:2020-08-26
  • Corresponding author: Yuan Liu
  • About author:
    Corresponding author: Liu Yuan, Email:
引用本文:

刘媛, 龙在云, 李森, 王海燕, 杨策. 脑冲击伤诊治的研究现状[J]. 中华诊断学电子杂志, 2020, 08(03): 145-149.

Yuan Liu, Zaiyun Long, Sen Li, Haiyan Wang, Ce Yang. The research status of diagnosis and treatment of blast traumatic brain injury[J]. Chinese Journal of Diagnostics(Electronic Edition), 2020, 08(03): 145-149.

在战斗中,由爆炸性武器引起的轻度冲击性脑损伤是最常见的脑损伤类型,并对参战人员的神经和认知功能有重要影响。爆炸冲击性脑损伤的诊断还需进一步明确,同时治疗方面必须考虑其是战争环境下发生的普遍性创伤和精神共病。笔者就军事人员爆炸冲击性脑创伤的流行病学、病理机制及临床分类特征进行综述。

In combat, mild blast traumatic brain injury (bTBI) is the most common type of brain injuries, which leads to significant neurological and cognitive impacts on military members. Diagnosis of bTBI is needed to be indentified further. At the same time, the highly prevalent traumatic and psychiatric comorbidities incurred in combat must be considered in the approach to treatment. This manuscript aims to review the epidemiological, neuropathological, and clinical characteristics of bTBI.

[1]
Cifu DX, Taylor BC, Carne WF, et al. Traumatic brain injury, posttraumatic stress disorder,and pain diagnoses in OIF/OEF/OND Veterans[J].J Rehabil Res Dev,2013,50(9): 1169-1176.
[2]
Sawyer TW, Josey T, Wang Y,et al.Investigations of primary blast-induced traumatic brain injury[J].Shock Waves,2018,28(1): 85-99.
[3]
Belmont PJ, McCriskin BJ, Sieg RN,et al.Combat wounds in Iraq and Afghanistan from 2005 to 2009[J].J Trauma Acute Care Surg,2012,73(1): 3-12.
[4]
Belmont PJ, Goodman GP, Zacchilli M, et al. Incidence and epidemiology of combat injuries sustained during " the surge" portion of operation Iraqi Freedom by a U.S.Army brigade combat team[J].J Trauma,2010,68(1): 204-210.
[5]
Ohnishi M, Kirkman E, Guy RJ,et al.Reflex nature of the cardiorespiratory response to primary thoracic blast injury in the anaesthetised rat[J].Exp Physiol,2001,86(3): 357-364.
[6]
Tümer N, Svetlov S, Whidden M, et al. Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla[J].Neurosci Lett,2013(544): 62-67.
[7]
Goeller J, Wardlaw A, Treichler D,et al.Investigation of cavitation as a possible damage mechanism in blast-induced traumatic brain injury[J].J Neurotrauma,2012,29(10): 1970-1781.
[8]
Westrol MS, Donovan CM, Kapitanyan R.Blast physics and pathophysiology of explosive injuries[J].Ann Emerg Med,2017,69(1): 4-9.
[9]
Holm L, Cassidy JD, Carroll LJ,et al.Summary of the WHO collaborating centre for neurotrauma task force on mild traumatic brain Injury[J].J Rehabil Med,2005,37(3): 137-141.
[10]
Magnuson J, Leonessa F, Ling GS.Neuropathology of explosive blast traumatic brain injury[J].Curr Neurol Neurosci Rep,2012,12(5): 570-579.
[11]
Ling G, Bandak F, Armonda R,et al.Explosive blast neurotrauma[J].J Neurotrauma,2009,26(6): 815-825.
[12]
Mckee AC, Daneshvar DH.The neuropathology of traumatic brain injury[J].Handb Clin Neurol,2015(127): 45-66.
[13]
Readnower RD, Chavko M, Adeeb S,et al.Increase in blood-brain barrier permeability,oxidative stress,and activated microglia in a rat model of blastinduced traumatic brain injury[J].J Neurosci Res,2010,88(16): 3530-3539.
[14]
Cernak I, Merkle AC, Koliatsos VE,et al.The pathobiology of blast injuries and blast-induced neurotrauma as identified using a new experimental model of injury in mice[J].Neurobiol Dis,2011,41(2): 538-551.

URL    
[15]
Cho HJ, Sajja VS, Vandevord PJ,et al.Blast induces oxidative stress,inflammation,neuronal loss and subsequent short-term memory impairment in rats[J].Neuroscience,2013(253): 9-20.

URL    
[16]
Gill J, Motamedi V, Osier N,et al.Moderate blast exposure results in increased IL-6 and TNFα in peripheral blood[J].Brain Behav Immun,2017(65): 90-94.
[17]
Mac Donald CL, Johnson AM, Cooper D,et al.Detection of blast-related traumatic brain injury in U.S.military personnel[J].N Engl J Med,2011,364(22): 2091-2100.
[18]
Bauman RA, Ling G, Tong L,et al.An introductory characterization of a combat-casualty-care relevant swine model of closed head injury resulting from exposure to explosive blast[J].J Neurotrauma,2009,26(6): 841-860.
[19]
De Lanerolle NC, Bandak F, Kang D,et al.Characteristics of an explosive blast-induced brain injury in an experimental model[J].J Neuropathol Exp Neurol,2011,70(11): 1046-57.
[20]
Lu J, Ng KC, Ling G,et al.Effect of blast exposure on the brain structure and cognition in Macaca fascicularis[J].J Neurotrauma,2012,29(7): 1434-1454.
[21]
刘媛,龙在云,余静,等.爆炸冲击性脑创伤神经病理机制的研究进展[J/CD].中华诊断学电子杂志,2020,8(2): 95-99.
[22]
Armonda RA, Bell RS, Vo AH,et al.Wartime traumatic cerebral vasospasm:recent review of combat casualties[J].Neurosurgery,2006,59(6): 1215-1225.
[23]
Liu B, Medda A, Woods D,et al.The integrated blast effects sensor suite:a rapidly developed,complex,system of systems[J].Mil Med,2015,180(Suppl 3): 195-200.
[24]
Bazarian JJ, Biberthaler P, Welch RD,et al.Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI):a multicentre observational study[J].Lancet Neurol,2018,17(9): 782-789.
[25]
Samson K.In the clinic-traumatic brain injury: FDA approves first blood test for brain bleeds after mild TBI/concussion[J].Neurol Today,2018:12-18.
[26]
Frankel M, Fan L, Yeatts SD, et al. The association of very early serum levels of S100B,GFAP,UCHL1,and SBDP with outcome in ProTECT III[J].J Neurotrauma,2019,36(20): 2863-2871.
[27]
汤竣杰,陈兴栋,毛敏,等.特殊环境下创伤后应激障碍的流行病学及干预策略[J/CD].中华诊断学电子杂志,2020,8(2): 90-94.
[28]
Coldren RL, Kelly MP, Parish RV,et al.Evaluation of the Military Acute Concussion Evaluation for use in combat operations more than 12 hours after injury[J].Mil Med,2010,175(7): 477-481.
[29]
McCrea M, Guskiewicz K, Doncevic S,et al.Day of injury cognitive performance on the Military Acute Concussion Evaluation (MACE) by U.S.military servicemembers in OEF/OIF[J].Mil Med,2014,179(9): 990-997.

URL    
[30]
Mucha A, Collins MW, Elbin RJ,et al.A brief vestibular/ocular motor screening (VOMS) assessment to evaluate concussions:preliminary findings[J].Am J Sports Med,2014,42(10): 2479-2486.

URL    
[31]
Yorke AM, Smith L, Babcock M,et al.Validity and reliability of the vestibular/ocular motor screening and associations with common concussion screening tools[J].Sports Health,2017,9(2): 174-180.
[32]
Kelly MP, Coldren RL, Parish RV, et al. Assessment of acute concussion in the combat environment[J].Arch Clin Neuropsychol,2012,27(4): 375-388.
[33]
Betthauser LM, Brenner LA, Cole W,et al.A clinical evidence-based approach to examine the effects of mTBI and PTSD symptoms on ANAM performance in recentlydeployed active duty soldiers:results from the warrior strong study[J].J Head Trauma Rehabil,2018,33(2): 91-100.
[34]
段朝霞,张洁元,陈魁君,等.爆炸冲击波所致轻度颅脑损伤的诊断与处理[J/CD].中华诊断学电子杂志,2016,4(1): 26-29.

URL    
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