切换至 "中华医学电子期刊资源库"

中华诊断学电子杂志 ›› 2021, Vol. 09 ›› Issue (03) : 207 -210. doi: 10.3877/cma.j.issn.2095-655X.2021.03.015

综述

细胞外囊泡在Barrett食管及食管腺癌诊断和发病中的研究进展
王军丽1, 张文平2,()   
  1. 1. 046000 长治医学院研究生院
    2. 046000 长治医学院附属和平医院心胸外科
  • 收稿日期:2020-10-20 出版日期:2021-08-26
  • 通信作者: 张文平

Research progress of extracellular vesicles in the diagnosis and pathogenesis of Barrett esophagus and esophageal adenocarcinoma

Junli Wang1, Wenping Zhang2,()   

  1. 1. Graduate School, Changzhi Medical College, Changzhi 046000, China
    2. Department of Cardiothoracic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China
  • Received:2020-10-20 Published:2021-08-26
  • Corresponding author: Wenping Zhang
引用本文:

王军丽, 张文平. 细胞外囊泡在Barrett食管及食管腺癌诊断和发病中的研究进展[J]. 中华诊断学电子杂志, 2021, 09(03): 207-210.

Junli Wang, Wenping Zhang. Research progress of extracellular vesicles in the diagnosis and pathogenesis of Barrett esophagus and esophageal adenocarcinoma[J]. Chinese Journal of Diagnostics(Electronic Edition), 2021, 09(03): 207-210.

近年来我国食管腺癌(EAC)的发病率呈升高趋势,Barrett食管(BE)患者是患EAC风险最高的人群。EAC的主要临床症状是进行性吞咽困难,早期症状不明显,较多患者发现并诊断时病情已进展为晚期,因此EAC预后普遍较差,对其早期筛查、预防及治疗必不可少。细胞外囊泡(EVs)内富含来源于亲代细胞的蛋白质、核酸、脂质等物质,由于这些物质可随亲代细胞的病理生理状态改变发生相应变化,因此EVs可应用于疾病的早期诊断。笔者对目前有关EVs作为诊断生物标志物的研究报道进行回顾,总结其在BE和EAC疾病进展过程中的作用,以对该疾病的实验研究和临床实践提供一定的帮助。

In recent years, the incidence of esophageal adenocarcinoma (EAC) is increasing in China, and Barrett esophagus (BE) is the highest risk group for EAC. The main clinical symptom of EAC is progressive dysphagia, the early symptoms are not obvious, and the disease has progressed to advanced stage when most patients are found and diagnosed. Therefore, the prognosis of EAC is generally poor, and early screening, prevention and treatment are still essential. Extracellular vesicles (EVs) are rich in proteins, nucleic acids, lipids and other substances derived from parental cells. EVs can be used in the early diagnosis of diseases since the contents of EVs have been shown to provide useful insights into cellular transformation and pro-oncogenic processes. This paper reviews current research reports on EVs as a diagnostic biomarker, and summarizes its role in the progression of BE and EAC, in order to provide some help for experimental research and clinical practice of these diseases.

[1]
Spechler SJ, Souza RF.Barrett′s esophagus[J].N Engl J Med,2014,371(9): 836-845.
[2]
陈星宇,孔令斌,张帆,等.沙棘干乳剂对小鼠食管上皮内瘤变的阻断作用初探[J/CD].中华诊断学电子杂志,2019,7(1): 54-58.
[3]
Lee TH, D′Asti E, Magnus N,et al.Microvesicles as mediators of intercellular communication in cancer-the emerging science of cellular′ debris′[J].Semin Immunopathol,2011,33(5): 455-467.
[4]
van der Vos KE, Abels ER, Zhang X, et al. Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain[J].Neuro Oncol,2016,18(1): 58-69.
[5]
Thery C, Witwer KW, Aikawa E,et al.Minimal information for studies of extracellular vesicles 2018(MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines[J].J Extracell Vesicles,2018,7(1): 1535750.
[6]
Shao H, Im H, Castro CM,et al.New technologies for analysis of extracellular vesicles[J].Chem Rev,2018,118(4): 1917-1950.
[7]
Gurunathan S, Kang MH, Jeyaraj M,et al.Review of the isolation,characterization,biological function,and multifarious therapeutic approaches of exosomes[J].Cells,2019,8(4): 307.
[8]
Abels ER, Breakefield XO.Introduction to extracellular vesicles: biogenesis,RNA cargo selection,content,release,and uptake[J]. Cell Mol Neurobiol,2016,36(3): 301-312.
[9]
Latifkar A, Hur YH, Sanchez JC,et al.New insights into extracellular vesicle biogenesis and function[J].J Cell Sci, 2019, 132(13): jcs222406.
[10]
Poteryaev D, Datta S, Ackema K,et al.Identification of the switch in early-to-late endosome transition[J]. Cell,2010,141(3): 497-508.
[11]
Shamseddine AA, Airola MV, Hannun YA.Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes[J].Adv Biol Regul,2015(57): 24-41.
[12]
Clague MJ, Urbé S.Multivesicular bodies[J].Curr Biol,2008,18(10): 402-404.
[13]
Tkach M, Thery C.Communication by extracellular vesicles:where we are and where we need to go[J].Cell,2016,164(6): 1226-1232.
[14]
Zomer A, Maynard C, Verweij FJ, et al. In vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior[J].Cell,2015,161(5): 1046-1057.
[15]
Srinivasan S, Yeri A, Cheah PS,et al.Small RNA sequencing across diverse biofuids identifes optimal methods for exRNA isolation[J].Cell,2019,177(2): 446-462.
[16]
Melo SA, Sugimoto H, O′Connell JT, et al. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis[J].Cancer Cell,2014,26(5): 707-721.
[17]
Uemura R, Murakami Y, Hashimoto A,et al.Expression of serum exosomal and esophageal microRNA in rat refux esophagitis[J].Int J Mol Sci,2017,18(8): 1611.
[18]
Bus P, Kestens C, Ten Kate FJW, et al. Profling of circulating microRNAs in patients with Barrett′s esophagus and esophageal adenocarcinoma[J].J Gastroenterol,2016,51(6): 560-570.
[19]
Ke X, Yan R, Sun Z, et al. Esophageal adenocarcinoma-derived extracellular vesicle microRNAs induce a no plastic phenotype in gastric organoids[J].Neoplasia,2017,19(11): 941-949.
[20]
Valcz G, Buzas EI, Kittel A,et al.En bloc release of MVB-like small extracellular vesicle clusters by colorectal carcinoma cells[J].J Extracell Vesicles,2019,8(1): 1596668.
[21]
Villarroya-Beltri C, Baixauli F, Gutierrez-Vazquez C,et al.Sorting it out:regulation of exosome loading[J].Semin Cancer Biol,2014,28(2014): 3-13.
[22]
Ridder K, Keller S, Dams M,et al.Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation[J].PLoS Biol,2014,16(3): e1001874.
[23]
Poehlmann A, Kuester D, Malfertheiner P,et al.Inflammation and Barrett′s carcinogenesis[J]. Pathol Res Pract,2012,208(5): 269-280.
[24]
Warnecke-Eberz U, Chon SH, Holscher AH,et al.Exosomal onco-miRs from serum of patients with adenocarcinoma of the esophagus:comparison of miRNA profiles of exosomes and matching tumor[J].Tumour Biol,2015,36(6): 4643-4653.
[25]
Bansal A, Lee IH, Hong X, et al. Feasibility of microRNAs as biomarkers for Barrett′s esophagus progression:a pilot cross-sectional,phase 2 biomarker study[J]. Am J Gastroenterol,2011,106(6): 1055-1063.
[26]
Chiam K, Wang T, Watson DI,et al.Circulating serum exosomal miRNAs as potential biomarkers for esophageal Adenocarcinoma[J].J Gastrointest Surg,2015,19(7): 1208-1215.
[27]
Hoshino A, Costa-Silva B, Shen TL, et al. Tumour exosome integrins determine organotropic metastasis[J].Nature,2015,527(7578): 329-335.
[28]
Rahbari M, Pecqueux M, Aust D,et al.Expression of glypican 3 is an independent prognostic biomarker in primary gastro-esophageal adenocarcinoma and corresponding serum exosomes[J].J Clin Med,2019,8(5): 696.
[29]
Melo SA, Luecke LB, Kahlert C,et al.Glypican-1 identifies cancer exosomes and detects early pancreatic cancer[J]. Nature,2015,523(7559): 177-182.
[30]
Kamerkar S, LeBleu VS, Sugimoto H,et al.Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer [J].Nature,2017,546(7659): 498-503.
[31]
Mohammadi S, Yousef F, Shabaninejad Z,et al.Exosomes and cancer:from oncogenic roles to therapeutic applications[J].IUBMB Life,2020,72(4): 724-748.
[1] 邵华, 那子悦, 荆慧, 李博, 王秋程, 程文. 术前经皮超声造影对乳腺癌腋窝前哨淋巴结转移及负荷的诊断价值[J]. 中华医学超声杂志(电子版), 2023, 20(08): 849-853.
[2] 张旭, 徐建平, 苏冬明, 王彩芬, 王大力, 张文智. 男性乳腺肿块的超声造影特征[J]. 中华医学超声杂志(电子版), 2023, 20(08): 854-859.
[3] 方晔, 谢晓红, 罗辉. 品管圈在提高前列腺癌穿刺检出率中的应用[J]. 中华医学超声杂志(电子版), 2023, 20(07): 722-727.
[4] 孙帼, 谢迎东, 徐超丽, 杨斌. 超声联合临床特征的列线图模型预测甲状腺乳头状癌淋巴结转移的价值[J]. 中华医学超声杂志(电子版), 2023, 20(07): 734-742.
[5] 代雯荣, 赵丽娟, 李智慧. 细胞外囊泡对胚胎着床影响的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 616-620.
[6] 兰青, 熊枝繁, 杨盛力. 甲胎蛋白在胃肝样腺癌中的作用机制及诊断预后研究进展[J]. 中华普通外科学文献(电子版), 2023, 17(05): 376-379.
[7] 冯冰, 邹秋果, 梁振波, 卢艳明, 曾奕, 吴淑苗. 老年非特殊型浸润性乳腺癌超声征象与分子生物学指标的临床研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 48-51.
[8] 栗艳松, 冯会敏, 刘明超, 刘泽鹏, 姜秋霞. STIP1在三阴性乳腺癌组织中的表达及临床意义研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 52-56.
[9] 尚培中, 张润萍, 张伟, 贾国洪, 李晓武, 苗建军, 刘冰. 梗阻性黄疸临床防治新技术单中心应用研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 104-107.
[10] 马伟强, 马斌林, 吴中语, 张莹. microRNA在三阴性乳腺癌进展中发挥的作用[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 111-114.
[11] 王鸿彬, 何晓, 吴菁宙. 腹腔镜近端胃切除术中背驮式间置空肠单通道重建术在AEG手术的安全性及抗反流效果研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 526-529.
[12] 李全喜, 唐辉军, 张健生, 杨飞. 基于MUSE-DWI与SS-DWI技术在前列腺癌图像中的对比研究[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(06): 553-557.
[13] 刘飞, 王影新, 马骍, 辛灵, 程元甲, 刘倩, 王悦, 张军军. 不同介质腔内心电图定位技术在乳腺癌上臂输液港植入术中应用的随机对照研究[J]. 中华临床医师杂志(电子版), 2023, 17(07): 760-764.
[14] 岳瑞雪, 孔令欣, 郝鑫, 杨进强, 韩猛, 崔国忠, 王建军, 张志生, 孔凡庭, 张维, 何文博, 李现桥, 周新平, 徐东宏, 胡崇珠. 乳腺癌HER2蛋白表达水平预测新辅助治疗疗效的真实世界研究[J]. 中华临床医师杂志(电子版), 2023, 17(07): 765-770.
[15] 王苏贵, 皇立媛, 姜福金, 吴自余, 张先云, 李强, 严大理. 异质性细胞核核糖蛋白A2B1在前列腺癌中的作用及其靶向中药活性成分筛选研究[J]. 中华临床医师杂志(电子版), 2023, 17(06): 731-736.
阅读次数
全文


摘要