| [1] |
Liu CL, Guo JL, Zhang X, et al. Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials[J]．Nat Rev Cardiol，2018，15(6)：351-370.
|
| [2] |
Mijanović O, Branković A, Panin AN，et al.Cathepsin B：a sellsword of cancer progression[J]．Cancer Lett，2019(449)：207-214.
|
| [3] |
Yadati T, Houben T, Bitorina A，et al.The ins and outs of cathepsins：physiological function and role in disease management[J]．Cells，2020，9(7)：1679.
|
| [4] |
Wang YP, Jia LL, Shen J，et al.Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis[J]．PLoS Pathog，2018，14(1)：e1006872.
|
| [5] |
Liu C, Cai ZL, Hu TT，et al.Cathepsin B aggravated doxorubicin-induced myocardial injury via NF-κB signalling[J]．Mol Med Rep，2020，22(6)：4848-4856.
|
| [6] |
Abdulla MH, Valli-Mohammed MA, Al-Khayal K，et al.Cathepsin B expression in colorectal cancer in a Middle East population: potential value as a tumor biomarker for late disease stages[J]．Oncol Rep，2017，37(6)：3175-3180.
|
| [7] |
Nishiga M, Wang DW, Han YL，et al.COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives[J]．Nat Rev Cardiol，2020，17(9)：543-558.
|
| [8] |
Padmanabhan P, Desikan R, Dixit NM.Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection[J]．PLoS Comput Biol，2020，16(12)：e1008461.
|
| [9] |
Yang J, Chen T, Zhou YF. Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes[J]．Hereditas，2021，158(1)：4.
|
| [10] |
Hua Y, Nair S．Proteases in cardiometabolic diseases：pathophysiology，molecular mechanisms and clinical applications[J]．Biochim Biophys Acta，2015，1852(2)：195-208.
|
| [11] |
Gonçalves I, Hultman K, Dunér P，et al.High levels of cathepsin D and cystatin B are associated with increased risk of coronary events[J]．Open Heart，2016，3(1)：e000353.
|
| [12] |
Patel S, Homaei A, El-Seedi HR，et al.Cathepsins: proteases that are vital for survival but can also be fatal[J]．Biomed Pharmacother，2018(105)：526-532.
|
| [13] |
Bäck M, Yurdagul A Jr, Tabas I，et al.Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities[J]．Nat Rev Cardiol，2019，16(7)：389-406.
|
| [14] |
Zhang X, Luo S, Wang M，et al.Cysteinyl cathepsins in cardiovascular diseases[J]．Biochim Biophys Acta Proteins Proteom，2020，1868(4)：140360.
|
| [15] |
Chen J, Tung CH, Mahmood U，et al.In vivo imaging of proteolytic activity in atherosclerosis[J]．Circulation，2002，105(23)：2766-2771.
|
| [16] |
Savastano LE, Zhou Q, Smith A, et al. Multimodal laser-based angioscopy for structural，chemical and biological imaging of atherosclerosis[J]．Nat Biomed Eng，2017(1)：0023.
|
| [17] |
Wu H, Du Q, Dai Q，et al.Cysteine protease cathepsins in atherosclerotic cardiovascular diseases[J]．J Atheroscler Thromb，2018，25(2)：111-123.
|
| [18] |
Zhang GP, Yue X, Li SQ.Cathepsin C interacts with TNF-α/p38 MAPK signaling pathway to promote proliferation and metastasis in hepatocellular carcinoma[J]．Cancer Res Treat，2020，52(1)：10-23.
|
| [19] |
Zhang Y, Chen Y, Zhang YZ，et al.Contribution of cathepsin B-dependent Nlrp3 inflammasome activation to nicotine-induced endothelial barrier dysfunction[J]．Eur J Pharmacol，2019(865)：172795.
|
| [20] |
Vidak E, Javoršek U, Vizovišek M，et al.Cysteine cathepsins and their extracellular roles: shaping the microenvironment[J]．Cells，2019，8(3)：264.
|
| [21] |
Oshi M, Newman S, Tokumaru Y，et al.Intra-Tumoral angiogenesis is associated with inflammation，immune reaction and metastatic recurrence in breast cancer[J]．Int J Mol Sci，2020，21(18)：6708.
|
| [22] |
Zhang J, Shan Y, Li Y，et al.Palmitate impairs angiogenesis via suppression of cathepsin activity[J]．Mol Med Rep，2017，15(6)：3644-3650.
|
| [23] |
Im E, Venkatakrishnan A, Kazlauskas A．Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells[J]．Mol Biol Cell，2005，16(8)：3488-3500.
|
| [24] |
Nakao S, Zandi S, Sun D，et al.Cathepsin B-mediated CD18 shedding regulates leukocyte recruitment from angiogenic vessels[J]．FASEB J，2018，32(1)：143-154.
|
| [25] |
Thibeaux S, Siddiqi S, Zhelyabovska O，et al.Cathepsin B regulates hepatic lipid metabolism by cleaving liver fatty acid-binding protein[J]．J Biol Chem，2018，293(6)：1910-1923.
|
| [26] |
Dinnes DLM, White MY, Kockx M, et al. Human macrophage cathepsin B-mediated C-terminal cleavage of apolipoprotein A-I at Ser228 severely impairs antiatherogenic capacity[J]．FASEB J，2016，30(12)：4239-4255.
|
| [27] |
Sheedy FJ, Grebe A, Rayner KJ，et al.CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation[J]．Nat Immunol，2013，14(8)：812-820.
|
| [28] |
Thompson PL, Nidorf SM.Anti-inflammatory therapy with canakinumab for atherosclerotic disease：lessons from the CANTOS trial[J]．J Thorac Dis，2018，10(2)：695-698.
|
| [29] |
Wang YC, Liu XX, Shi H，et al.NLRP3 inflammasome，an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases[J]．Clin Transl Med，2020，10(1)：91-106.
|
| [30] |
Schultheiss HP, Fairweather D, Caforio ALP, et al. Dilated cardiomyopathy[J]．Nat Rev Dis Primers，2019，5(1)：32.
|
| [31] |
Liu L, Huang JJ, Liu Y，et al.Multiomics analysis of transcriptome，epigenome，and genome uncovers putative mechanisms for dilated cardiomyopathy[J]．Biomed Res Int，2021(2021)：6653802.
|
| [32] |
Wu QQ, Xu M, Yuan Y，et al.Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-α/ASK1/JNK pathway[J]．Am J Physiol Heart Circ Physiol，2015，308(9)：1143-1154.
|
| [33] |
Lian D, Lai JQ, Wu YJ，et al.Cathepsin B-mediated NLRP3 inflammasome formation and activation in angiotensin Ⅱ-induced hypertensive mice: role of macrophage digestion dysfunction[J]．Cell Physiol Biochem，2018，50(4)：1585-1600.
|
| [34] |
Xie L, Terrand J, Xu B，et al.Cystatin C increases in cardiac injury：a role in extracellular matrix protein modulation[J]．Cardiovasc Res，2010，87(4)：628-635.
|
| [35] |
Camardo A, Carney S, Ramamurthi A．Assessing the targeting and fate of cathepsin k antibody-modified nanoparticles in a rat abdominal aortic aneurysm model[J]．Acta Biomater，2020(112)：225-233.
|
| [36] |
Yuan Z, Lu Y, Wei J，et al.Abdominal aortic aneurysm: roles of inflammatory cells[J]．Front Immunol，2020(11)：609161.
|
| [37] |
Lohoefer F, Reeps C, Lipp C，et al.Histopathological analysis of cellular localization of cathepsins in abdominal aortic aneurysm wall[J]．Int J Exp Pathol，2012，93(4)：252-258.
|