幽门螺杆菌(Hp)分离培养成功已近40年，在这近40年中，对Hp的研究持久而深入，但对Hp感染与人类胃疾病之间关系的表述仍有值得商榷之处。研究发现，Hp可能是人体内的一种定植菌，Hp感染只是人类慢性胃炎可能病因之一；Hp相关性慢性胃炎的临床表现至今没有定论，目前研究描述的所谓慢性胃炎的临床症状，如腹胀、腹痛等只是人云亦云的结果；Hp相关性慢性萎缩性胃炎和肠化生癌变的概率尚不清楚。笔者希望应该加强对Hp与人类疾病关系的研究，对这两者关系的宣传，无论在科学上，还是在科普上均宜慎重对待。在此，对Hp感染、慢性胃炎、肠化生三者的关系作一综述。

It has been nearly 40 years for the success of isolation and culture of Helicobacter pylori(Hp) . During the nearly 40 years, the investigation of Hp is persistent and intensive. However, the presentation of the relationship between Hp and human gastric diseases deserves further discussion. The studies have found that Hp might be a common colonization strain of human body and the infection of Hp is only one of the causes of human chronic gastritis. The clinical presentations of Hp related chronic gastritis is not known with certainty up to now. The clinical presentations of chronic gastritis described by studies at present, such as abdominal distention and abdominal pain, are echoes of what others say. It is unclear what's the probability of canceration of Hp related chronic atrophic gastritis and intestinal metaplasia. The authors of this paper hope to strengthen the investigation of the relationship between Hp and human diseases. The propaganda of the causal relationship of these two factors should be treated carefully, both in the field of science and popularization of science. This article summarizes the relationship of Hp infection, chronic gastritis and intestinal metaplasia.