切换至 "中华医学电子期刊资源库"

中华诊断学电子杂志 ›› 2022, Vol. 10 ›› Issue (02) : 109 -112. doi: 10.3877/cma.j.issn.2095-655X.2022.02.008

内分泌代谢性疾病诊治

糖尿病患者中胰岛素样生长因子1水平与甲状腺疾病的相关性研究进展
栾若蔚1, 张梅2,()   
  1. 1. 272013 济宁医学院临床医学院
    2. 272029 济宁医学院附属医院内分泌科 中国生长发育疾病行为医学研究中心
  • 收稿日期:2021-12-12 出版日期:2022-04-26
  • 通信作者: 张梅

Progress in studies on the correlation between IGF-1 level and thyroid diseases in diabetic patients

Ruowei Luan1, Mei Zhang2,()   

  1. 1. College of Clinical Medicine, Jining Medical University, Jining 272013, China
    2. Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining 272029, China
  • Received:2021-12-12 Published:2022-04-26
  • Corresponding author: Mei Zhang
引用本文:

栾若蔚, 张梅. 糖尿病患者中胰岛素样生长因子1水平与甲状腺疾病的相关性研究进展[J/OL]. 中华诊断学电子杂志, 2022, 10(02): 109-112.

Ruowei Luan, Mei Zhang. Progress in studies on the correlation between IGF-1 level and thyroid diseases in diabetic patients[J/OL]. Chinese Journal of Diagnostics(Electronic Edition), 2022, 10(02): 109-112.

胰岛素样生长因子1(IGF-1)是人体最重要、作用最广泛的细胞因子之一,具有促进人体生长发育、物质代谢及细胞分化、增殖等作用。IGF-1的氨基酸序列与胰岛素具有同源性,因此具有与胰岛素相似的降血糖作用。既往研究表明,糖尿病患者血清IGF-1水平较非糖尿病患者低。同时,IGF-1对甲状腺功能有直接或间接的刺激作用,其可与促甲状腺激素(TSH)共同影响碘的摄取及有机化,进而导致甲状腺功能异常。近年来,甲状腺疾病在糖尿病患者中的发病率逐年升高,现将糖尿病患者IGF-1水平与甲状腺疾病的相关性研究进展作一综述。

Insulin-like growth factor 1 (IGF-1) is one of the most important and extensive functional cytokines the body. It can promote growth and development, substance metabolism, cell differentiation and proliferation. The amino acid sequence of IGF-1 is homologous to insulin, so it has hypoglycemic effect similar to insulin. Previous studies have shown that serum IGF-1 levels are lower in the people with diabetes than those in the people without diabetes. At the same time, IGF-1 can stimulate thyroid function directly or indirectly, and it can affect iodine uptake and organic synthesis together with the thyrotropin (TSH), leading to abnormal thyroid function. In recent years, the incidence of thyroid disease in patients with diabetes is increasing year by year. This paper reviews the research progress of the correlation between IGF-1 levels and thyroid diseases in diabetic patients.

[1]
Ogurtsova K, da Rocha Fernandes JD, Huang Y,et al.IDF diabetes atlas:global estimates for the prevalence of diabetes for 2015 and 2040[J].Diabetes Res Clin Pract2017(128):40-50.DOI:10.1016/j.diabres.2017.03.024.
[2]
牛玲,李博一,张建伟,等.昆明地区糖尿病患者甲状腺结节患病率[J].昆明医科大学学报201738(5):78-82.
[3]
Garmendia Madariaga A, Santos Palacios S, Guillén-Grima F,et al.The incidence and prevalence of thyroid dysfunction in europe:a meta-analysis[J].J Clin Endocrinol Metab201499(3):923-931.DOI:10.1210/jc.2013-2409.
[4]
Centeno Maxzud M, Gómez Rasjido L, Fregenal M,et al.Prevalence of thyroid dysfunction in patients with type 2 diabetes mellitus[J].Medicina(B Aires)201676(6):355-358.
[5]
Subekti I, Pramono LA, Dewiasty E,et al.Thyroid dysfunction in type 2 diabetes mellitus patients[J].Acta Med Indones201749(4):314-323.
[6]
Wang H, Zhang H, Cao F,et al.Protection of insulin-like growth factor 1 on experimental peripheral neuropathy in diabetic mice[J].Mol Med Rep201818(5):4577-4586.DOI:10.3892/mmr.2018.9435.
[7]
Mancuso E, Mannino GC, Fatta CD,et al.Insulin-like growth factor-1 is a negative modulator of glucagon secretion[J].Oncotarget20178(31):51719-51732.DOI:10.18632/oncotarget.18514.
[8]
Maximus PS.Insulin like growth factor 1 is linked to higher cardiovascular risk score in adults with type 2 diabetes mellitus and chronic kidney disease[J].Diabetes Metab Syndr201913(4):2613-2618.DOI:10.1016/j.dsx.2019.07.008.
[9]
Aguirre GA, González-Guerra JL, Espinosa L,et al.Insulin-like growth factor 1 in the cardiovascular system[J].Rev Physiol Biochem Pharmacol2018(175):1-45.DOI:10.1007/112_2017_8.
[10]
Nederstigt C, Corssmit EP, de Koning EJ,et al.Incidence and prevalence of thyroid dysfunction in type 1 diabetes[J].J Diabetes Complications201630(3):420-425.DOI:10.1016/j.jdiacomp.2015.12.027.
[11]
Gu Y, Li H, Bao X,et al.The relationship between thyroid function and the prevalence of type 2 diabetes mellitus in euthyroid subjects[J].J Clin Endocrinol Metab2017102(2):434-442.DOI:10.1210/jc.2016-2965.
[12]
蒋正,陈敏华.糖尿病合并甲状腺功能异常的相关危险因素研究[J].中国医学工程201826(3):4-6.DOI:10.19338/j.issn.1672-2019.2018.03.002.
[13]
郝鑫,施秉银,赵新.2型糖尿病住院患者甲状腺功能分析[J].中国现代医药杂志201517(1):74-75.DOI:10.3969/j.issn.1672-9463.2015.01.038.
[14]
许晓燕,李肃宁.2型糖尿病合并甲状腺疾病的临床分析[J].宁夏医学杂志201638(9):795-797.DOI:10.13621/j.1001-5949.2016.09.0795.
[15]
姜晓洪.中老年2型糖尿病合并甲状腺功能异常患者的临床特点分析[J].保健医学研究与实践202118(3):65-68.DOI:10.11986/j.issn.1673-873X.2021.03.012.
[16]
胡晓黎.2型糖尿病合并甲状腺功能异常的临床分析[J].特别健康2019(36):64.
[17]
Subekti I, Pramono LA, Dewiasty E,et al.Thyroid dysfunction in type 2 diabetes mellitus patients[J].Acta Med Indones201749(4):314-323.
[18]
Sierra-Johnson J, Romero-Corral A, Somers VK, et al. IGF-I/IGFBP-3 ratio:a mechanistic insight into the metabolic [J].Clin Sci(Lond)2009116(6):507-512.DOI:10.1042/CS20080382.
[19]
Åsvold BO, Vatten LJ, Midthjell K, et al. Serum TSH within the reference range as a predictor of future hypothyroidism and hyperthyroidism:11-year follow-up of the HUNT Study in Norway[J].J Clin Endocrinol Metab201297(1):93-99.DOI:10.1210/jc.2011-1724.
[20]
Kadiyala R, Peter R, Okosieme OE.Thyroid dysfunction in patients with diabetes:clinical implications and screening strategies[J].Int J Clin Pract201064(8):1130-1139.DOI:10.1111/j.1742-1241.2010.02376.x.
[21]
Shapiro MR, Wasserfall CH, McGrail SM,et al.Insulin-like growth factor dysregulation both preceding and following type 1 diabetes diagnosis[J].Diabetes202069(3):413-423.DOI:10.2337/db19-0942.
[22]
Drogan D, Schulze MB, Boeing H,et al.Insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in relation to the risk of type 2 diabetes mellitus:results from the EPIC-potsdam study[J].Am J Epidemiol2016183(6):553-560.DOI:10.1093/aje/kwv188.
[23]
孙娜娜,韩立坤.男性2型糖尿病合并良性甲状腺结节患者的内分泌激素特征[J].中国医科大学学报201948(6):515-518,524.
[24]
Yamanaka Y, Wilson EM, Rosenfeld RG,et al.Inhibition of insulin receptor activation by insulin-like growth factor binding proteins[J].J Biol Chem1997272(49):30729-30734.DOI:10.1074/jbc.272.49.30729.
[25]
王凤玲,邓海荣,刘玉枝,等.碘致甲状腺功能异常及其与IGF-1和IGFBP-3表达的研究进展[J].医学综述201824(9):1676-1680,1686.DOI:10.3969/j.issn.1006-2084.2018.09.003.
[26]
Martin S, Sirbu A, Betivoiu M, et al. IGF1 deficiency in newly diagnosed Graves′ disease patients[J].Hormones (Athens)201514(4):651-659.DOI:10.14310/horm.2002.1577.
[27]
Morgan SJ, Neumann S, Marcus-Samuels B,et al.Thyrotropin and insulin-like growth factor 1 receptor crosstalk Upregulates sodium-iodide Symporter expression in primary cultures of human Thyrocytes[J].Thyroid201626(12):1794-1803.DOI:10.1089/thy.2016.0323.
[28]
Krieger CC, Boutin A, Jang D, et al. Arrestin-beta-1 physically scaffolds TSH and IGF1 receptors to enable crosstalk[J].Endocrinology2019160(6):1468-1479.DOI:10.1210/en.2019-00055.
[29]
Douglas RS, Kahaly GJ, Patel A, et al. Teprotumumab for the treatment of active thyroid eye disease[J].N Engl J Med2020382(4):341-352.DOI:10.1056/NEJMoa1910434.
[30]
焦丽静,闫园园,王宝镯,等.血清胰岛素样生长因子-1与2型糖尿病患者甲状腺结节TI-RADS分级的相关性研究[J].华北理工大学学报(医学版)202022(5):382-386,392.DOI:10.19539/j.cnki.2095-2694.2020.05.009.
[31]
Altas A, Kuzu F, Arpaci D,et al.The clinical values of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels in blood and thyroid nodules[J].Int J Endocrinol2017(2017):3145234.DOI:10.1155/2017/3145234.
[32]
Schmidt JA, Allen NE, Almquist M, et al. Insulin-like growth factor-1 and risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition[J].Cancer Epidemiol Biomarkers Prev201423(6):976-985.DOI:10.1158/1055-9965.EPI-13-1210-T.
[33]
Lawnicka H, Motylewska E, Borkowska M,et al.Elevated serum concentrations of IGF-1 and IGF-1R in patients with thyroid cancers[J].Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub2020164(1):77-83.DOI:10.5507/bp.2019.018.
[34]
余彩英.糖尿病与甲状腺功能异常之间的关系分析[J].心理月刊202015(10):169.DOI:10.19738/j.cnki.psy.2020.10.145.
[35]
廖明,尹琦,梁江燕,等.胰岛素样生长因子结合蛋白相关蛋白1与2型糖尿病胰岛素抵抗的相关性研究[J].糖尿病新世界201720(9):17-19,62.DOI:10.16658/j.cnki.1672-4062.2017.09.017.
[36]
Kimura T, Van Keymeulen A, Golstein J,et al.Regulation of thyroid cell proliferation by TSH and other factors:a critical evaluation of in vitro models[J].Endocr Rev200122(5):631-656.DOI:10.1210/edrv.22.5.0444.
[37]
闫园园,魏剑芬,李世超,等.血清胰岛素样生长因子-1与糖尿病合并甲状腺疾病的相关性[J].广东医学20194(5):647-651.DOI:10.13820/j.cnki.gdyx.20182780.
[38]
魏剑芬,闫园园,王宝镯,等.糖尿病合并甲状腺机能亢进症患者血清IGF-1水平的变化 [J].华北理工大学学报(医学版)201921(1):7-10,15.DOI:10.19539/j.cnki.2095-2694.2019.01.002.
[1] 章建全, 程杰, 陈红琼, 闫磊. 采用ACR-TIRADS评估甲状腺消融区的调查研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 966-971.
[2] 曹雯佳, 刘学兵, 罗安果, 钟释敏, 邓岚, 王玉琳, 李赵欢. 超声矢量血流成像对2型糖尿病患者颈动脉壁剪切应力的研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(07): 709-717.
[3] 王杰, 袁泉, 王玥琦, 乔佳君, 谭春丽, 夏仲元, 刘守尧. 溃疡油在糖尿病足溃疡治疗中的应用效果及安全性观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 480-484.
[4] 徐志刚, 曹涛, 何亭, 李博奥, 魏婧韬, 张栋梁, 官浩, 杨薛康. 采用抗生素骨水泥治疗糖尿病患者心脏术后胸骨骨髓炎的临床效果观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 498-502.
[5] 姜珊, 李湘燕, 田硕涵, 温冰, 何睿, 齐心. 采用优化抗感染治疗模式改善糖尿病足感染预后的临床观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(05): 398-403.
[6] 别瑶, 曹志斌, 辛静, 王健楠, 惠宗光. 应用基质血管成分细胞治疗糖尿病足溃疡的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(05): 453-456.
[7] 孟令凯, 李大勇, 王宁, 王桂明, 张炳南, 李若彤, 潘立峰. 袖状胃切除术对肥胖伴2型糖尿病大鼠的作用及机制研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 638-642.
[8] 李猛, 姜腊, 董磊, 吴情, 贾犇黎. 腹腔镜胃袖状切除术治疗肥胖合并2型糖尿病及脂肪胰的临床研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(05): 554-557.
[9] 严虹霞, 王晓娟, 张毅勋. 2 型糖尿病对结直肠癌患者肿瘤标记物、临床病理及预后的影响[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 483-487.
[10] 周学锋, 董哲毅, 冯哲, 蔡广研, 陈香美. 糖尿病肾脏疾病中西医结合诊疗指南计划书[J/OL]. 中华肾病研究电子杂志, 2024, 13(06): 301-305.
[11] 杜军霞, 赵小淋, 王浩然, 高志远, 王曼茜, 万楠熙, 张冬, 丁潇楠, 任琴琴, 段颖洁, 汤力, 朱晗玉. 2 型糖尿病的血液透析患者肠道微生物组学高通量测序分析[J/OL]. 中华肾病研究电子杂志, 2024, 13(06): 313-320.
[12] 邱岭, 朱旭丽, 浦坚, 邢苗苗, 吴佳玲. 糖尿病肾病患者肠道菌群生态特点与胃肠道功能障碍的关联性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 453-458.
[13] 王璇, 娜扎开提·尼加提, 雒洋洋, 蒋升. 皮肤晚期糖基化终末产物浓度与2型糖尿病微血管并发症的相关性[J/OL]. 中华临床医师杂志(电子版), 2024, 18(05): 447-454.
[14] 王星, 陈园, 热孜万古丽·乌斯曼, 郭艳英. T2DM、Obesity、NASH、PCOS共同致病因素相关的分子机制[J/OL]. 中华临床医师杂志(电子版), 2024, 18(05): 481-490.
[15] 李玺, 蔡芸莹, 张永红, 苏恒. 假性软骨发育不全合并1型糖尿病一例[J/OL]. 中华临床医师杂志(电子版), 2024, 18(05): 518-520.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?