酒精性心肌病病理分子机制的研究进展

doi:10.3877/cma.j.issn.2095-655X.2022.04.007

酒精性心肌病(ACM)是一种由于长期大量饮酒所引发的非缺血性扩张型心肌病，发病率逐年增高。ACM的发病机制涉及酒精及其代谢产物的直接毒性作用、氧化应激、细胞凋亡与自噬、线粒体功能障碍、蛋白质代谢异常和神经内分泌系统失衡等多方面，且尚未明确，临床表现及诊断也缺乏特异性。笔者主要对ACM的发病机制、病理特征、临床特征、诊断与治疗等方面的研究进展进行综述，以提高医务工作者对其的认识。

关键词: 心肌病，酒精性, 心肌病，扩张型, 发病机制, 诊断, 治疗

Alcoholic cardiomyopathy (ACM), a type of non-ischemic dilated cardiomyopathy whose morbidity is rising year by year, is brought on by heavy drinking. With clinical manifestations and diagnosis lacking specificity, the pathogenesis of ACM includes the direct toxic effects of alcohol and its metabolites, oxidative stress, apoptosis and autophagy, mitochondrial dysfunction, abnormal protein metabolism, neuroendocrine system imbalance, and other unknown factors. This article mainly reviews the research progress in the pathogenesis, pathological features, clinical features, diagnosis and treatment of ACM, so as to improve the understanding of medical professionals.

Key words: Cardiomyopathy, alcoholic, Cardiomyopathy, dilated, Pathogenesis, Diagnosis, Treatment

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Advances in molecular mechanisms of alcoholic cardiomyopathy

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Advances in molecular mechanisms of alcoholic cardiomyopathy