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中华诊断学电子杂志 ›› 2023, Vol. 11 ›› Issue (03) : 145 -152. doi: 10.3877/cma.j.issn.2095-655X.2023.03.001

专题笔谈

"长新冠"诊断基础及其对直升机飞行人员作业效能的影响
朱莹, 周阿香, 李森, 王旭, 齐光辉, 杨策()   
  1. 400042 重庆,陆军军医大学大坪医院野战外科研究部 创伤与化学中毒全国重点实验室
    310009 杭州,浙江大学医学院附属第二医院急诊科
    362100 泉州,73159部队91分队
  • 收稿日期:2023-06-05 出版日期:2023-08-26
  • 通信作者: 杨策
  • 基金资助:
    院士牵头科技创新引导专项(2022YSZX-JCX0015CSTB); 陆军军事理论科研项目(LJ2022D10-C001)

The diagnostic basis of long COVID and its effects on the operational efficiency for helicopter pilots

Ying Zhu, Axiang Zhou, Sen Li, Xu Wang, Guanghui Qi, Ce Yang()   

  1. State Key Laboratory of Trauma and Chemical Poisoning, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Department of Emergency, the Second Affiliated Hospital of Medical College in Zhejiang University, Hangzhou 310009, China
    Contingent 91 of Unit 73159, Quanzhou 362100, China
  • Received:2023-06-05 Published:2023-08-26
  • Corresponding author: Ce Yang
引用本文:

朱莹, 周阿香, 李森, 王旭, 齐光辉, 杨策. "长新冠"诊断基础及其对直升机飞行人员作业效能的影响[J]. 中华诊断学电子杂志, 2023, 11(03): 145-152.

Ying Zhu, Axiang Zhou, Sen Li, Xu Wang, Guanghui Qi, Ce Yang. The diagnostic basis of long COVID and its effects on the operational efficiency for helicopter pilots[J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(03): 145-152.

"长新冠"是新型冠状病毒感染(COVID-19)者发病后或无症状感染者确诊后3个月存在的、持续至少2个月,且无法由其他诊断解释的症状。作为2019年冠状病毒感染后部分患者客观存在、多器官系统受累且临床症状多样的综合征,"长新冠"的病理生理学、危险因素和治疗方法尚不明确。但越来越多的证据表明,即使在健康的年轻COVID-19患者中,心脏、肺和凝血功能障碍以及神经精神后遗症也可能发生。这种疾病的潜在表现可能会导致直升机飞行人员作业效能下降,甚至可能导致飞行人员突然丧失能力。鉴于目前"长新冠"对直升机飞行人员的影响鲜有研究,笔者主要从"长新冠"对飞行人员身体各个系统的影响着手,对先前的研究进行总结,旨在厘清"长新冠"的诊断基础以及如何影响飞行人员的作业效能,并从航空卫生保障层面,提出加强"长新冠"直升机飞行人员体检和健康鉴定、做好飞行作业放飞标准把控、飞行全过程卫生监督、疫苗规范化接种、特医食品和营养剂补充及心理综合康复干预的一体化干预措施,为航医做好直升机飞行人员COVID-19康复后的健康保障以及复飞检查提供新思路。

Long COVID was defined as a symptom that persisted for at least 2 months after the onset of illness or 3 months after the diagnosis of an asymptomatic person with coronavirus disease 2019 (COVID-19) and could not be explained by other diagnoses. Presently, long COVID, as a syndrome objectively existing in some patients after COVID-19, with multiple organ systems involved and various clinical symptoms, has not yet reached a consensus on the diagnosis. The possible pathophysiology, risk factors, and treatments of long COVID remain unclear, with our current understanding incomplete. Increasing evidences shows that cardiac, pulmonary, and coagulation disorders and neuropsychological sequelae can occur even in healthy young adults with COVID-19. The underlying manifestations may lead to decreased operational effectiveness and potentially cause sudden incapacitation of helicopter aircrews. However, there are few relevant articles on the effect of long COVID on helicopter pilots. Therefore, this article starts with the effect of long COVID on various systems of the body of flying personnel, summarizes previous studies, and aims to clarify the diagnostic basis of long COVID and how it affects the performance of flying personnel. From the perspective of aviation health support, the integrated intervention measures after long COVID are presented concerning strengthening the physical examination and health appraisal of helicopter pilots, controlling flight operation release standards, health supervision throughout the entire flight process, standardized vaccination, supplementation of special medical food and nutrients, and comprehensive psychological rehabilitation intervention. It aims to provide ideas for the health care and re-flight inspection of helicopter flying personnel after recovery from COVID-19 infection.

表1 "长新冠"的常见临床表现
[1]
Davis HE, McCorkell L, Vogel JM, et al. Long COVID: major findings,mechanisms and recommendations[J].Nat Rev Microbiol202321(3):133-146.DOI:10.1038/s41579-022-00846-2.
[2]
Perlis RHLunz Trujillo KSafarpour A,et al.Association of post-COVID-19 condition symptoms and employment status[J].JAMA Netw Open20236(2):e2256152.DOI:10.1001/jamanetworkopen.2022.56152.
[3]
Ballering AVvan Zon SOlde Hartman TC,et al.Persistence of somatic symptoms after COVID-19 in the Netherlands:an observational cohort study[J].Lancet2022400(10350):452-461.DOI:10.1016/S0140-6736(22)01214-4.
[4]
Antonelli M, Pujol JC, Spector TD, et al. Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2[J].Lancet2022399(10343):2263-2264.DOI:10.1016/S0140-6736(22)00941-2.
[5]
Klein JWood JJaycox J,et al.Distinguishing features of Long COVID identified through immune profiling[J].medRxiv2022.DOI:10.1101/2022.08.09.22278592.
[6]
Glynne PTahmasebi NGant V,et al.Long COVID following mild SARS-CoV-2 infection:characteristic T cell alterations and response to antihistamines[J].J Investig Med202270(1):61-67.DOI:10.1136/jim-2021-002051.
[7]
Phetsouphanh CDarley DRWilson DB,et al.Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection[J].Nat Immunol202223(2):210-216.DOI:10.1038/s41590-021-01113-x.
[8]
Schultheiβ CWillscher EPaschold L,et al.The IL-1β,IL-6,and TNF cytokine triad is associated with post-acute sequelae of COVID-19[J].Cell Rep Med20223(6):100663.DOI:10.1016/j.xcrm.2022.100663.
[9]
Peluso MJLu STang AF,et al.Markers of immune activation and inflammation in individuals with postacute sequelae of severe acute respiratory syndrome coronavirus infection[J].J Infect Dis2021224(11):1839-1848.DOI:10.1093/infdis/jiab490.
[10]
Fernández-Castañeda ALu PGeraghty AC,et al.Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain[J].bioRxiv2022.DOI:10.1101/2022.01.07.475453.
[11]
Swank ZSenussi YManickas-Hill Z,et al.Persistent circulating severe acute respiratory syndrome coronavirus 2 spike is associated with post-acute coronavirus disease 2019 sequelae[J].Clin Infect Dis202376(3):e487-e490.DOI:10.1093/cid/ciac722.
[12]
Natarajan AZlitni SBrooks EF,et al.Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection[J].Med20223(6):371-387.e9.DOI:10.1016/j.medj.2022.04.001.
[13]
Zubchenko SKril INadizhko O,et al.Herpesvirus infections and post-COVID-19 manifestations:a pilot observational study[J].Rheumatol Int202242(9):1523-1530.DOI:10.1007/s00296-022-05146-9.
[14]
Su YYuan DChen DG,et al.Multiple early factors anticipate post-acute COVID-19 sequelae[J].Cell2022185(5):881-895.e20.DOI:10.1016/j.cell.2022.01.014.
[15]
Davis HEAssaf GSMcCorkell L,et al.Characterizing long COVID in an international cohort:7 months of symptoms and their impact[J].EClinicalMedicine2021(38):101019.DOI:10.1016/j.eclinm.2021.101019.
[16]
Datta SDTalwar ALee JT.A proposed framework and timeline of the spectrum of disease due to SARS-CoV-2 infection:illness beyond acute infection and public health implications[J].JAMA2020324(22):2251-2252.DOI:10.1001/jama.2020.22717.
[17]
Ceban FLing SLui L,et al.Fatigue and cognitive impairment in post-COVID-19 syndrome:a systematic review and meta-analysis[J].Brain Behav Immun2022(101):93-135.DOI:10.1016/j.bbi.2021.12.020.
[18]
Reiken SSittenfeld LDridi H,et al.Alzheimer′s-like signaling in brains of COVID-19 patients[J].202218(5):955-965.DOI:10.1002/alz.12558.
[19]
Bitirgen GKorkmaz CZamani A,et al.Corneal confocal microscopy identifies corneal nerve fibre loss and increased dendritic cells in patients with long COVID[J].Br J Ophthalmol2022106(12):1635-1641.DOI:10.1136/bjophthalmol-2021-319450.
[20]
Barros AQueiruga-Piñeiro JLozano-Sanroma J,et al.Small fiber neuropathy in the cornea of Covid-19 patients associated with the generation of ocular surface disease[J].Ocul Surf2022(23):40-48.DOI:10.1016/j.jtos.2021.10.010.
[21]
Bitirgen G, Korkmaz C, Zamani A, et al. Abnormal quantitative pupillary light responses following COVID-19[J].Int Ophthalmol202242(9):2847-2854.DOI:10.1007/s10792-022-02275-9.
[22]
Lough MAlmufarrij IWhiston H,et al.Revised meta-analysis and pooled estimate of audio-vestibular symptoms associated with COVID-19[J].Int J Audiol202261(8):705-709.DOI:10.1080/14992027.2021.1962552.
[23]
Morin LSavale LPham T,et al.Four-month clinical status of a cohort of patients after hospitalization for COVID-19[J].JAMA2021325(15):1525-1534.DOI:10.1001/jama.2021.3331.
[24]
Bellan MSoddu DBalbo PE,et al.Respiratory and psychophysical sequelae among patients with COVID-19 four months after hospital discharge[J].JAMA Netw Open20214(1):e2036142.DOI:10.1001/jamanetworkopen.2020.36142.
[25]
Huang CHuang LWang Y,et al.6-month consequences of COVID-19 in patients discharged from hospital:a cohort study[J].Lancet2021397(10270):220-232.DOI:10.1016/S0140-6736(20)32656-8.
[26]
Poyraz Poyraz CAOlgun Y,et al.Psychiatric morbidity and protracted symptoms after COVID-19[J].Psychiatry Res2021(295):113604.DOI:10.1016/j.psychres.2020.113604.
[27]
Yu JZGranberg TShams R,et al.Lung perfusion disturbances in nonhospitalized post-COVID with dyspnea-a magnetic resonance imaging feasibility study[J].J Intern Med2022292(6):941-956.DOI:10.1111/joim.13558.
[28]
Vijayakumar BBoustani KOgger PP,et al.Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease[J].Immunity202255(3):542-556.e5.DOI:10.1016/j.immuni.2022.01.017.
[29]
Evans PCRainger GEMason JC,et al.Endothelial dysfunction in COVID-19:a position paper of the ESC working group for atherosclerosis and vascular biology,and the ESC council of basic cardiovascular science[J].Cardiovasc Res2020116(14):2177-2184.DOI:10.1093/cvr/cvaa230.
[30]
Haffke MFreitag HRudolf G,et al.Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS)[J].J Transl Med202220(1):138.DOI:10.1186/s12967-022-03346-2.
[31]
Kubánková MHohberger BHoffmanns J,et al.Physical phenotype of blood cells is altered in COVID-19[J].Biophys J2021120(14):2838-2847.DOI:10.1016/j.bpj.2021.05.025.
[32]
Xie YXu EBowe B,et al.Long-term cardiovascular outcomes of COVID-19[J].Nat Med202228(3):583-590.DOI:10.1038/s41591-022-01689-3.
[33]
Puntmann VOCarerj MLWieters I,et al.Outcomes of cardiovascular magnetic resonance imaging in patients recently recovered from coronavirus disease 2019 (COVID-19)[J].JAMA Cardiol20205(11):1265-1273.DOI:10.1001/jamacardio.2020.3557.
[34]
Roca-Fernandez AWamil MTelford A,et al.Cardiac abnormalities in long COVID 1-year post-SARS-CoV-2 infection[J].Open Heart202310(1)e002241.DOI:10.1136/openhrt-2022-002241.
[35]
Meringer HMehandru S.Gastrointestinal post-acute COVID-19 syndrome[J].Nat Rev Gastroenterol Hepatol202219(6):345-346.DOI:10.1038/s41575-022-00611-z.
[36]
Yeoh YKZuo TLui GC,et al.Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19[J].Gut202170(4):698-706.DOI:10.1136/gutjnl-2020-323020.
[37]
Liu QMak JSu Q,et al.Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome[J].Gut202271(3):544-552.DOI:10.1136/gutjnl-2021-325989.
[38]
Zuo TLiu QZhang F,et al.Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19[J].Gut202170(2):276-284.DOI:10.1136/gutjnl-2020-322294.
[39]
Patel PJBorovskiy YKillian A,et al.Optimal QT interval correction formula in sinus tachycardia for identifying cardiovascular and mortality risk:findings from the Penn Atrial Fibrillation Free study[J].Heart Rhythm201613(2):527-535.DOI:10.1016/j.hrthm.2015.11.008.
[40]
Giannis DZiogas IAGianni P.Coagulation disorders in coronavirus infected patients:COVID-19,SARS-CoV-1,MERS-CoV and lessons from the past[J].J Clin Virol2020(127):104362.DOI:10.1016/j.jcv.2020.104362.
[41]
Colling ME, Kanthi Y. COVID-19-associated coagulopathy:an exploration of mechanisms[J].Vasc Med202025(5):471-478.DOI:10.1177/1358863X20932640.
[42]
Ptacek RPtackova HMartin A,et al.Psychiatric manifestations of COVID-19 and their social significance[J].Med Sci Monit2020(26):e930340.DOI:10.12659/MSM.930340.
[43]
Watson OJBarnsley GToor J,et al.Global impact of the first year of COVID-19 vaccination:a mathematical modelling study[J].Lancet Infect Dis202222(9):1293-1302.DOI:10.1016/S1473-3099(22)00320-6.
[44]
Feikin DRHigdon MMAbu-Raddad LJ,et al.Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease:results of a systematic review and meta-regression[J].Lancet2022399(10328):924-944.DOI:10.1016/S0140-6736(22)00152-0.
[45]
Steele MKCouture AReed C,et al.Estimated number of COVID-19 infections,hospitalizations,and deaths prevented among vaccinated persons in the US,December 2020 to September 2021 [J].JAMA Network Open20225(7):e2220385.DOI:10.1001/jamanetworkopen.2022.20385.
[46]
Notarte KICatahay JAVelasco JV,et al.Impact of COVID-19 vaccination on the risk of developing long-COVID and on existing long-COVID symptoms:a systematic review[J].E Clinical Medicine2022(53):101624.DOI:10.1016/j.eclinm.2022.101624.
[47]
Tofarides AGChristaki EMilionis H,et al.Effect of vaccination against SARS-CoV-2 on long COVID-19:a narrative review[J].Life (Basel)202212(12).DOI:10.3390/life12122057.
[48]
Yong SJ. Long COVID or post-COVID-19 syndrome: putative pathophysiology,risk factors,and treatments[J].Infect Dis (Lond)202153(10):737-754.DOI:10.1080/23744235.2021.1924397.
[49]
Naureen ZDautaj ANodari S,et al.Proposal of a food supplement for the management of post-COVID syndrome[J].Eur Rev Med Pharmacol Sci202125(1 Suppl):67-73.DOI:10.26355/eurrev_202112_27335.
[50]
Breedvelt JAmanvermez YHarrer M,et al.The effects of meditation,yoga,and mindfulness on depression,anxiety,and stress in tertiary education students:a meta-analysis[J].Front Psychiatry2019(10):193.DOI:10.3389/fpsyt.2019.00193.
[51]
Shi LZhang DWang L,et al.Meditation and blood pressure:a meta-analysis of randomized clinical trials[J].J Hypertens201735(4):696-706.DOI:10.1097/HJH.0000000000001217.
[52]
Schutte NSMalouff JMKeng SL.Meditation and telomere length:a meta-analysis[J].Psychol Health202035(8):901-915.DOI:10.1080/08870446.2019.1707827.
[53]
Hilton LHempel SEwing BA,et al.Mindfulness meditation for chronic pain:systematic review and meta-analysis[J].Ann Behav Med201751(2):199-213.DOI:10.1007/s12160-016-9844-2.
[54]
Montero-Marin JGarcia-Campayo JPérez-Yus MC,et al.Meditation techniques v.relaxation therapies when treating anxiety:a meta-analytic review[J].Psychol Med201949(13):2118-2133.DOI:10.1017/S0033291719001600.
[55]
Wang XLi PPan C,et al.The effect of mind-body therapies on insomnia:a systematic review and meta-analysis[J].Evid Based Complement Alternat Med2019(2019):9359807.DOI:10.1155/2019/9359807.
[56]
Wu LLLin ZKWeng HD,et al.Effectiveness of meditative movement on COPD:a systematic review and meta-analysis[J].Int J Chron Obstruct Pulmon Dis2018(13):1239-1250.DOI:10.2147/COPD.S159042.
[57]
Weber MSchnorr TMorat M,et al.Effects of mind-body interventions involving meditative movements on quality of life,depressive symptoms,fear of falling and sleep quality in older adults:a systematic review with meta-analysis[J].Int J Environ Res Public Health202017(18).DOI:10.3390/ijerph17186556.
[58]
Dong BXie CJing X,et al.Yoga has a solid effect on cancer-related fatigue in patients with breast cancer:a meta-analysis[J].Breast Cancer Res Treat2019177(1):5-16.DOI:10.1007/s10549-019-05278-w.
[59]
Gallegos AMCrean HFPigeon WR,et al.Meditation and yoga for posttraumatic stress disorder:a meta-analytic review of randomized controlled trials[J].Clin Psychol Rev2017(58):115-124.DOI:10.1016/j.cpr.2017.10.004.
[60]
Chan JDeng KWu J,et al.Effects of meditation and mind-body exercises on older adults′ cognitive performance:a meta-analysis[J].Gerontologist201959(6):e782-e790.DOI:10.1093/geront/gnz022.
[61]
Wong MCHuang JWong YY,et al.Epidemiology,symptomatology,and risk factors for long COVID symptoms:population-based,multicenter study[J].JMIR Public Health Surveill2023(9):e42315.DOI:10.2196/42315.
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