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中华诊断学电子杂志 ›› 2023, Vol. 11 ›› Issue (03) : 165 -168. doi: 10.3877/cma.j.issn.2095-655X.2023.03.004

内分泌代谢性疾病诊治

反复发作的糖尿病纹状体病的影像学特征并文献复习
徐长贺, 尚海龙, 于乐林, 王一超, 赵世伟, 沈慧, 叶娟, 杜红娣, 王莺, 沈海林()   
  1. 215028 苏州,上海交通大学医学院苏州九龙医院影像科
  • 收稿日期:2022-09-27 出版日期:2023-08-26
  • 通信作者: 沈海林
  • 基金资助:
    苏州市医学会应用基础研究-医疗卫生基金项目(2022YX-Q04)

Imaging features of recurrent diabetic striatopathy and literature review

Changhe Xu, Hailong Shang, Lelin Yu, Yichao Wang, Shiwei Zhao, Hui Shen, Juan Ye, Hongdi Du, Ying Wang, Hailin Shen()   

  1. Department of Imaging, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou 215028, China
  • Received:2022-09-27 Published:2023-08-26
  • Corresponding author: Hailin Shen
引用本文:

徐长贺, 尚海龙, 于乐林, 王一超, 赵世伟, 沈慧, 叶娟, 杜红娣, 王莺, 沈海林. 反复发作的糖尿病纹状体病的影像学特征并文献复习[J]. 中华诊断学电子杂志, 2023, 11(03): 165-168.

Changhe Xu, Hailong Shang, Lelin Yu, Yichao Wang, Shiwei Zhao, Hui Shen, Juan Ye, Hongdi Du, Ying Wang, Hailin Shen. Imaging features of recurrent diabetic striatopathy and literature review[J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(03): 165-168.

目的

探讨糖尿病纹状体病的临床及影像学特征。

方法

回顾性分析2020年11月12日上海交通大学医学院苏州九龙医院神经内科收治的1例反复发作的糖尿病纹状体病患者的临床及影像学资料,并复习文献,总结该病的临床及影像学特征。

结果

1例老年女性患者因左侧上肢偏侧舞蹈样运动2 d入院,入院时静脉随机葡萄糖38.62 mmol/L,颅脑CT示右侧基底节区高密度影,头颅MRI示右侧纹状体T1WI高信号,磁敏感加权成像(SWI)序列未见明显异常信号。予胰岛素降糖、补液、纠正电解质紊乱等治疗,并予抗血小板聚集、降脂稳定斑块、改善循环、营养脑细胞、调控血压等对症治疗,1周后血糖控制稳定,复查头颅MRI提示右侧纹状体T1WI高信号强度减低,症状好转。患者出院1个月后因左下肢不自主舞蹈样扭动再次入院,复查头颅MRI提示右侧纹状体T1WI高信号,血糖轻度增高伴炎症指标较高,两肺感染,予降糖、抗感染治疗,患者下肢扭动症状消失。

结论

患者出现亚急性单侧肢体舞蹈样运动障碍、存在控制不佳的糖尿病、颅脑CT和MRI提示对侧纹状体高密度影和T1WI高信号时,应考虑糖尿病纹状体病,感染也可导致该病的复发,该病的影像表现具有一定的可逆性。

Objective

To explore the clinical and imaging features of diabetic striatopathy(DS).

Methods

The clinical and imaging data of a patient with recurrent DS who was admitted to Department of Neurology of Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine on November 12, 2020, were analyzed retrospectively, and the literature was reviewed to summarize the disease's clinical and imaging features.

Results

An eldly female patient was admitted for a 2 d dance-like movement on the left side of her upper limb. At the time of admission, the random venous glucose level was 38.62 mmol/L. Cranial CT revealed a high density shadow in the right basal ganglia, while cranial MRI revealed a high signal intensity in the right striatum on T1WI, with no obvious abnormal signal on susceptibility weighted imaging (SWI). Insulin hypoglycemic therapy, fluid rehydration, electrolyte correction, and other symptomatic treatments such as anti-platelet aggregation, lipid-stabilizing plaque, improving circulation, nourishing brain cells, and regulating blood pressure were administered to the patient. A week later, blood glucose control had stabilized, and a cranial MRI revealed that the high signal intensity of the right striatum T1WI had been reduced, and the symptoms had been improved. One month after discharge, the patient was readmitted to the hospital due to involuntary writhing of the left lower limb. A re-examination of the cranial MRI revealed a high T1WI signal in the right striatum, a slight increase in blood glucose with high inflammatory markers, and infection of both lungs. After receiving hypoglycemic and anti-infection treatment, the patient′s lower limb symptoms resolved.

Conclusions

Patients with subacute unilateral dance-like dyskinesia, poorly controlled diabetes, contralateral striatum high density shadow, and T1WI high signal on cranial CT and MRI should be evaluated for DS. Infection can also cause disease recurrence, and the imaging manifestations of the disease are reversible to some extent.

图1 糖尿病纹状体病患者治疗前后颅脑影像学检查图像注:a图为患者首次入院时颅脑CT检查图像,横断位示右侧基底节区密度影较对侧明显增高;b图为患者首次入院时头颅MRI检查图像,示右侧基底节区斑片状T1WI高信号;c、d图为患者入院治疗1周后复查头颅MRI图像,c图示右侧基底节区斑片状T1WI高信号,d图示磁敏感加权成像未见含铁血黄素沉积;e图为患者出院1个月后复发头颅MRI图像,示右侧纹状体斑片状T1WI高信号;b、c、e图右侧基底节区T1WI高信号的灰度均值分别为863、773、797(箭头所示)
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