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中华诊断学电子杂志 ›› 2025, Vol. 13 ›› Issue (01) : 32 -37. doi: 10.3877/cma.j.issn.2095-655X.2025.01.005

妇科疾病诊治

巨大多房囊性子宫平滑肌瘤的诊断学特征并文献复习
张茜茹1, 袁迎雪1, 曹智新1,()   
  1. 1. 250021 济南,山东第一医科大学附属省立医院病理科
  • 收稿日期:2024-12-15 出版日期:2025-02-26
  • 通信作者: 曹智新
  • 基金资助:
    山东第一医科大学科学培育支持计划基金(202201-061)

Diagnostic features and literature review of giant multilocular cystic leiomyoma of the uterus

Xiru Zhang1, Yingxue Yuan1, Zhixin Cao1,()   

  1. 1. Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
  • Received:2024-12-15 Published:2025-02-26
  • Corresponding author: Zhixin Cao
引用本文:

张茜茹, 袁迎雪, 曹智新. 巨大多房囊性子宫平滑肌瘤的诊断学特征并文献复习[J/OL]. 中华诊断学电子杂志, 2025, 13(01): 32-37.

Xiru Zhang, Yingxue Yuan, Zhixin Cao. Diagnostic features and literature review of giant multilocular cystic leiomyoma of the uterus[J/OL]. Chinese Journal of Diagnostics(Electronic Edition), 2025, 13(01): 32-37.

目的

探讨巨大多房囊性子宫平滑肌瘤的诊断学特征。

方法

结果

患者女性,36 岁,自觉腹部增大2 年余,加重2 个月,伴尿频、腹水及体重增加。 超声检查提示盆腹腔巨大囊实性占位,考虑卵巢恶性肿瘤;右附件区囊性包块,考虑畸胎瘤;子宫浆膜下肌瘤。 盆腹腔增强CT 初步考虑卵巢囊腺癌。 病理诊断为盆腹腔巨大多房囊性平滑肌瘤,最大横径49.2 cm;合并卵巢成熟性囊性畸胎瘤及子宫平滑肌瘤。 经切除后,随访17 个月,无复发。

结论

巨大多房囊性平滑肌瘤以罕见的囊性变为特点,且体积大,依靠影像学检查诊断困难,需要通过组织病理学和免疫组化明确诊断。

Objective

To investigate the diagnostic features of giant multilocular cystic leiomyoma of uterus.

Methods

The clinical data of a newly diagnosed patient with a giant pelvic cavity mass admitted to the Gynecology Department of Shandong Provincial Hospital on August 5, 2023 were collected, and the literature was reviewed to summarize the diagnostic features of giant multilocular cystic leiomyoma.

Results

The patient, a 36-year-old female, had experienced abdominal enlargement for more than 2 years,with worsening symptoms over the past 2 months, accompanied by frequent urination, ascites, and weight gain. Ultrasound examination revealed a large cystic-solid mass in the abdominal pelvic cavity, initially suspected as an ovarian malignancy, and a cystic mass in the right adnexal area, suspected to be a teratoma,and subserous myoma of the uterus. Enhanced CT of the pelvis and abdomen initially suggested ovarian cystadenocarcinoma. The pathological diagnosis was giant multilocular cystic leiomyoma in the pelvic cavity,with a maximum transverse diameter of 49.2 cm, complicated with mature cystic teratoma of the ovary and leiomyoma of the uterus. The patient was followed up for 17 months after resection without recurrence.

Conclusion

Giant multilocular cystic leiomyoma, characterized by rare cystic changes and large size, is difficult to diagnose by imaging examination and needs to be confirmed by histopathology and immunohistochemistry.

图1 盆腹腔巨大占位患者盆腹腔增强CT 图像 注:a 图为冠状面,CT 可见巨大不规则囊实性密度肿块影;b 图为横断面,可见明显不均质强化,病变上方以囊性密度为主,可见多发粗细不等分隔,增强扫描分隔可见强化
图2 盆腹腔巨大占位患者手术切除病理标本大体图像 注:a、b 图为盆腹腔囊肿图像,a 图可见部分内壁附暗红色血块,b 图可见部分内壁附灰黄坏死物质(箭头所示);c 图为右侧卵巢畸胎瘤囊内含皮脂毛发,局部可见头节(箭头所示)
图3 盆腹腔巨大占位患者盆腹腔肿物病理学及免疫组织化学染色图像 注: a 图示盆腹腔囊肿壁,可见梭形细胞交叉排列(HE ×40); b 图示盆腹腔囊肿壁,由分化良好的梭形平滑肌细胞束构成,细胞核钝圆,未见核分裂象(HE ×400); c 图示囊壁组织未见内衬上皮,部分区域可见出血及胆固醇结晶(HE ×100); d 图示灶性区域可见钙化及含铁血黄素沉积(HE ×100)(箭头所示); e 图囊壁组织内梭形细胞Desmin 呈阳性(×100); f 图囊壁组织内梭形细胞SMA 呈阳性(×100) ;g 图囊壁组织内梭形细胞Ki-67 约2%呈阳性(×100) ;h 图囊壁组织内梭形细胞PR 呈阳性(×100);Desmin 为结蛋白;SMA 为平滑肌肌动蛋白;Ki-67 为增殖细胞核抗原;PR 为孕激素受体
图4 盆腹腔巨大占位患者子宫及右卵巢肿物病理学图像 注:a 图示子宫浆膜下肌瘤,可见交织状排列的长梭形细胞(HE ×100); b 图示右卵巢畸胎瘤,可见分化成熟的多胚层结构,可见分化好的鳞状上皮、皮脂腺、纤维结缔组织(箭头所示)(HE ×40)
表1 文献复习6 例巨大囊性平滑肌瘤患者及本例患者诊断学特征汇总
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