探讨体重指数与血脂水平及非酒精性脂肪肝(non-alcoholic fatty liver disease, NAFLD)的关系。

对2012年1月至2013年1月于安徽省立医院参加健康体检，病史及饮酒史资料完整的10000名体检者的人体质量指数(BMI)与其相关临床指标进行统计分析。按照BMI将人群分组，不同体重指数人群间血脂水平及NAFLD检出率差异采用χ²检验。

(1)所有体检人群中超重及肥胖者5996例，占60%，正常体重者3829例，占38.3%；(2)超重和肥胖在不同年龄组人群中的构成比差异有统计学意义(χ²＝161.733，P＝0.000；(3)除高密度脂蛋白(HDL-C)外，超重组和肥胖组的甘油三脂(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)水平均明显高于体重正常组；(4)NAFLD和高脂血症的发生率随BMI水平升高而逐渐增加；(5)性别(男性)、BMI、TG、TC为NAFLD发生的独立危险因素，HDL-C为保护因素；(6)ROC曲线分析BMI预测NAFLD发生的最佳切点为(男性：24.85或24.95；女性24.95)。

超重及肥胖是发生NAFLD和高脂血症的危险因素，应加强对体重的干预，以改善脂代谢和降低NAFLD的发生。

To analyze the relationship between body mass index, lipid profile and non-alcoholic fatty liver disease (NAFLD).

A population-based, cross-sectional study was carried out in 10 000 clients of health examination in the population of Hefei area in 2012. Body mass index (BMI), history of alcohol intake and past medical history were recorded. Subjects were divided into four groups according to the levels of BMI, clinical indicators included serum lipids, and fasting blood glucose and the rate of non-alcoholic fatty liver disease were compared among the four groups. Distribution of BMI of the masses in Hefei region was analyzed. The relationships between BMI and the incidences of hyperlipidemia and non-alcoholic fatty liver disease were discussed.

(1)The occurring rate of obesity and overweight was 60%, normal weight was 38.3%. (2)The incidence of overweight and obesity was distinct in different age groups (χ²=161.733, P=0.000). (3)Except for high density lipoprotein-cholesterol, indicators included triglyceride, total cholesterol, low density lipoprotein-cholesterol, fasting blood sugar and uric acid levels in overweight and obesity groups were significantly higher than those in normal group. (4)With the increasing of BMI, the incidence of non-alcoholic fatty liver disease and hyperlipidemia were increased. (5)Factors including BMI, gender (male), triglyceride, total cholesterol were independent risk for non-alcoholic fatty liver disease, whereas high density lipoprotein cholesterol was a protective factor. (6)ROC analysis demonstrated that the best cut off value of BMI in predicting the incidence of non-alcoholic fatty liver disease was 24.85 or 24.95 in male and 24.95 in female.

Overweight and obesity are the risk factors for the prevalence of NAFLD and hyperlipidemia. Management of weight and targeted interventions rectifying the metabolism disorders at the earliest opportunity, which may contribute to reduce the risk of hyperlipidemia and NAFLD.