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中华诊断学电子杂志

中华诊断学电子杂志 ›› 2014, Vol. 02 ›› Issue (01) : 58 -60. doi: 10.3877/cma.j.issn.2095-655X.2014.012

所属专题： 文献；

临床研究

药物滥用性头痛患者认知功能及事件相关电位P300的研究
徐存理1,†(), 刘洪强1, 文庆贤1, 王瑞科1   
  1. 1. 272011　济宁市第一人民医院神经内科（康复医学中心）
  • 收稿日期:2013-10-06 出版日期:2014-02-26
  • 通信作者: 徐存理
  • 基金资助:
    济宁市医学计划项目(2009-56)

Clinical research of the cognitive function and event-related potential P300 in patients with medication-overuse headache

Cunli Xu1,†(), Hongqiang Liu1, Qingxian Wen1, Ruike Wang1   

  1. 1. Department of Rehabililation Medicine Center, The First people's Hospital of jining, Jining 272033, China
  • Received:2013-10-06 Published:2014-02-26
  • Corresponding author: Cunli Xu
  • About author:
    Corresponding author: XuCunli, Email:
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徐存理, 刘洪强, 文庆贤, 王瑞科. 药物滥用性头痛患者认知功能及事件相关电位P300的研究[J]. 中华诊断学电子杂志, 2014, 02(01): 58-60.

Cunli Xu, Hongqiang Liu, Qingxian Wen, Ruike Wang. Clinical research of the cognitive function and event-related potential P300 in patients with medication-overuse headache[J]. Chinese Journal of Diagnostics(Electronic Edition), 2014, 02(01): 58-60.

目的

探讨药物滥用性头痛(MOH)患者认知功能及认知电位的变化情况。

方法

MOH患者(观察组)及对照组各30例，两组均进行P300、简易精神状态量表(MMSE)检测。采用SPSS 10.0软件进行数据处理，P300潜伏期、波幅比较采用t检验。

结果

两组P300靶刺激中P3潜伏期、波幅比较均差异有统计学意义：观察组P3潜伏期[分别为(393.70±42.60)ms]较对照组[(331.05±22.35)ms]延长，差异有统计学意义(t＝7.13，P<0.05)；观察组P3波幅[(3.40±2.30)uV]较对照组[(6.20±2.40)uV]明显降低，差异也有统计学意义(t＝4.59，P<0.05)。两组MMSE评分比较，观察组总分、定向力、记忆力、计算力、回忆力、语言能力[(24.00±2.21)分，(8.15±0.86)分，(2.88±0.23)分，(3.07±1.04 )分，(1.72±0.89)分，(8.42±1.33)分]低于对照组[分别为(27.07±2.06)分，(9.28±1.03)分，(3.01±0.26)分，(3.25±1.20)分，(1.92±0.90)分，(9.69±1.44)分]，总分、定向力、语言能力评分差异有统计学意义(t＝3.66，3.19，3.34；P<0.05)。

结论

MOH患者存在轻度的认知功能障碍，认知电位P300为MOH患者认知功能障碍的诊断提供一客观指标。

关键词: 镇痛药, 头痛症, 继发性, 认知, 事件相关电位，P300
Objectives

To explore the changes of cognitive function and potential in patients with medication-overuse headache (MOH).

Methods

The subjects were divided into two groups: observation group (patients with MOH, n=30) and control group (n=30). P300 was used to detect the cognitive potential and mini mental state examination (MMSE) was performed to evaluate the cognitive function of the subjects.

Results

The differences between the two groups were significant.The P3 latency in observation group [(393.70±42.60) ms] was more prolonged than that in the control group (331.05±22.35) ms]. The difference between the two groups was significant(t=7.13, P<0.05); The amplitudes of P3 in observation group [(3.40±2.30)uV], was lower than that in the control group[ (6.20±2.40)uV]. The difference between the two groups was also significant(t=4.59, P<0.05). The MMSE in observation group were shown as follows: total score (24.00±2.21), orientation (8.15±0.86), anamnesis (2.88±0.23), calculation (3.07±1.04), recall (1.72±0.89) and language (8.42±1.33). In control group, the MMSE were shown as total score (27.07±2.06), orientation (9.28±1.03), anamnesis (3.01±0.26), calculation (3.25±1.20), recall (1.92±0.90) and language (9.69±1.44). The differences between the two groups were all significant (t=3.66, 3.19, 3.34, P<0.01).

Conclusion

The patients with MOH had the mild cognitive impairment, and P300 cognitive potential could provide objective indicators for the diagnosis of cognitive dysfunction of patients with MOH.

Key words: Analgesils, Headache disorders, secondary, Cognition, Event-related potentials, P300
表1 两组肌电图诱发电位检测P300各波潜伏期和波幅的比较(±s)
组别 例数 潜伏期(ms) 波幅(uV)
N1 P2 N2 P3 P2 P3
观察组 30 93.20±13.30 164.04±26.90 219.60±22.40 393.70±42.60 4.16±3.40 3.40±2.30
对照组 30 88.07±18.20 158.82±6.49 212.70±19.40 331.05±22.35 5.06±3.84 6.20±2.40
t值 ? 1.21 1.03 1.28 7.13 0.96 4.59
P值 ? >0.05 >0.05 >0.05 <0.05 >0.05 <0.05
表2 两组精神状态量表评分比较(分，±s)
组别 例数 总分 定向力 记忆力 计算力 回忆力 语言能力
病例组 30 24.00±2.21 8.15±0.86 2.88±0.23 3.07±1.04 1.72±0.89 8.42±1.33
对照组 30 27.07±2.06 9.28±1.03 3.01±0.26 3.25±1.20 1.92±0.90 9.69±1.44
t值 ? 3.66 3.19 1.81 1.56 1.46 3.35
P值 ? <0.05 <0.05 >0.05 >0.05 >0.05 <0.05
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