胃炎、食管炎和食管癌患者血清中人丝氨酸蛋白酶8的表达及临床意义

doi:10.3877/cma.j.issn.2095-655X.2016.01.013

中华诊断学电子杂志 ›› 2016, Vol. 04 ›› Issue (01) : 45 -47. doi: 10.3877/cma.j.issn.2095-655X.2016.01.013

所属专题：文献；

临床研究

胃炎、食管炎和食管癌患者血清中人丝氨酸蛋白酶8的表达及临床意义

李凯¹, 赵卫星¹, 鲍永华², 杨万才³^,^†(

)

^1. 453100　新乡医学院第一附属医院病理科
^2. 453003　新乡医学院基础医学院免疫学教研室
^3. 453003　新乡医学院基础医学院病理教研室

收稿日期:2015-12-03 出版日期:2016-02-26
通信作者: 杨万才
基金资助:
国家自然科学基金(91229115)

The serum levels of PRSS8 and their clinical significance in the patients with gastritis, esophagitis and esophageal cancer

Kai Li¹, Weixing Zhao¹, Yonghua Bao², Wancai Yang³^,^†()

^1. Department of Pathology, the First Affiliated Hospital of Xinxiang Medical University, Weihui 453100
^2. Department of Immunology, Xinxiang Medical University, Xinxiang 453003, China
^3. Department of Pathology, Xinxiang Medical University, Xinxiang 453003, China

Received:2015-12-03 Published:2016-02-26
Corresponding author: Wancai Yang
About author:
Corresponding author: Yang Wancai, Email: yang3029106@126.com

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目的

探讨人丝氨酸蛋白酶8(PRSS8)在胃炎、食管炎和食管癌患者血清中的表达情况及意义。

方法

采集临床诊断为食管炎、食管癌和胃炎患者以及正常人群的血清样本，其中食管炎患者血清样本20例，食管癌患者血清样本6例，胃炎患者血清样本60例，正常血清样本28例。采用酶联免疫吸附法(ELISA)的方法测定各组中PRSS8的表达水平，并将食管炎患者组、食管癌患者组和胃炎患者组分别与正常组相比较。

结果

各组血清PRSS8表达水平差异有统计学意义(F＝13.24，P<0.01)。食管炎患者组PRSS8表达水平[(4.58±1.67)μg/L]高于正常组[(3.52±1.49)μg/L]，差异有统计学意义(LSD-t＝2.59，P<0.05)；食管癌患者组PRSS8表达水平[(5.05±0.57)μg/L]高于正常组[(3.52±1.49)μg/L]，差异有统计学意义(LSD-t＝2.54，P<0.05)；食管癌患者组PRSS8表达水平[(5.05±0.57)μg/L]高于食管炎患者组[(4.58±1.67)μg/L]，差异无统计学意义(LSD-t＝0.83，P>0.05)；胃炎患者组PRSS8表达水平[(5.39±1.04)μg/L]高于正常组[(3.52±1.49)μg/L]，差异有统计学意义(LSD-t＝6.22，P<0.05)。

结论

食管炎、食管癌和胃炎患者血清中PRSS8表达水平均增高，提示血清中的PRSS8可能与食管炎、食管癌和胃炎的发生发展相关。

关键词: 食管炎, 食管肿瘤, 胃炎, 丝氨酸蛋白酶类, 血清

Objective

To study the expression level and significance of serum human protease serine 8(PRSS8) in the patient with gastritis, esophagitis and esophageal cancer.

Methods

The serum samples from healthy subjects and the patients diagnosed as esophagitis, esophageal cancer and gastritis were collected.The serum samples included 20 esophagitis serum samples, 6 esophageal cancer serum samples, 60 gastritis serum samples and 28 healthy serum samples.The expression level of PRSS8 was detected by ELISA assay.Then the serum PRSS8 levels from the esophagitis group, esophageal cancer group and the gastritis group were compared with the healthy group, respectively.

Results

The serum level of PRSS8 in esophagitis group [(4.58±1.67)μg/L] was higher than that from the healthy group [(3.52±1.49)μg/L], the difference was statistically significant(LSD-t=2.59, P<0.05). The serum level of PRSS8 in esophageal cancer group [(5.05±0.57)μg/L] was higher than that from the healthy group [(3.52±1.49)μg/L], the difference was statistically significant(LSD-t=2.54, P<0.05). The serum level of PRSS8 in esophageal cancer group [(5.05±0.57)μg/L] was higher than that from the esophagitis group [(4.58±1.67)μg/L], the difference was not statistically significant(LSD-t=0.83, P>0.05). The level of serum PRSS8 in gastritis group [(5.39±1.04)μg/L] was higher than that from the healthy group [(3.52±1.49)μg/L], the difference was also statistically significant (LSD-t=6.22, P<0.05).

Conclusion

Serum PRSS8 expression levels are obviously increased in the patients with esophagitis, esophageal cancer and gastritis, which suggests that serum PRRS8 maybe relate to the development of esophagitis, esophageal cancer and gastritis.

Key words: Esophagitis, Esophageal neoplasms, Gastritis, Serine proteases, Serum

表1 各组间血清PRSS8水平比较(μg/L，±s)

组别	例数	血清PRSS8水平
正常组	28	3.52±1.49
胃炎组	60	5.39±1.04^a
食管炎组	20	4.58±1.67^a
食管癌组	6	5.05±0.57^a
F值	?	13.24
P值	?	0.000

表1 各组间血清PRSS8水平比较(μg/L，±s)

组别	例数	血清PRSS8水平
正常组	28	3.52±1.49
胃炎组	60	5.39±1.04^a
食管炎组	20	4.58±1.67^a
食管癌组	6	5.05±0.57^a
F值	?	13.24
P值	?	0.000

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