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中华诊断学电子杂志 ›› 2016, Vol. 04 ›› Issue (04) : 255 -256. doi: 10.3877/cma.j.issn.2095-655X.2016.04.010

所属专题: 文献

肿瘤诊治研究

胸苷酸合酶及其抑制剂与非小细胞肺癌的研究进展
鲁葆华1, 张同梅1, 李宝兰1,()   
  1. 1. 101149 首都医科大学附属北京胸科医院肿瘤科
  • 收稿日期:2016-10-10 出版日期:2016-11-26
  • 通信作者: 李宝兰
  • 基金资助:
    首都医科大学基础临床合作基金(14JL84)

Research of thymidylate synthase and its inhibitors in non-small cell lung cancer

Baohua Lu1, Tongmei Zhang1, Baolan Li1,()   

  1. 1. Department of General, Beijing Chest Hospital Affiliated to Capital Medical University, Beijing 101149, China
  • Received:2016-10-10 Published:2016-11-26
  • Corresponding author: Baolan Li
  • About author:
    Corresponding author: Li Baolan, Email:
引用本文:

鲁葆华, 张同梅, 李宝兰. 胸苷酸合酶及其抑制剂与非小细胞肺癌的研究进展[J]. 中华诊断学电子杂志, 2016, 04(04): 255-256.

Baohua Lu, Tongmei Zhang, Baolan Li. Research of thymidylate synthase and its inhibitors in non-small cell lung cancer[J]. Chinese Journal of Diagnostics(Electronic Edition), 2016, 04(04): 255-256.

胸苷酸合酶是抗肿瘤药物作用的主要酶。常见的胸苷酸合酶抑制剂培美曲塞二钠和爱斯万因疗效肯定、副反应轻在非小细胞肺癌中广泛应用。笔者就胸苷酸合酶及其抑制剂与非小细胞肺癌的研究进展做一综述。

Thymidylate synthase(TS) is the major enzyme of antitumor drugs. Pemetrexed disodium and S-1 are the most common TS inhibitors, and widely used in the treatment of non-small cell lung cancer (NSCLC) because of their curative effect and mild side-effect. In this review, we will mainly discuss the research progress of thymidylate synthase and its inhibitors in NSCLC.

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