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中华诊断学电子杂志 ›› 2017, Vol. 05 ›› Issue (04) : 217 -220. doi: 10.3877/cma.j.issn.2095-655X.2017.04.001

所属专题: 文献

专题笔谈

循环microRNAs在溃疡性结肠炎发病和肠道炎症活动的作用
刘继喜1,()   
  1. 1. 100029 北京,中日友好医院消化内科
  • 收稿日期:2017-07-23 出版日期:2017-11-26
  • 通信作者: 刘继喜

The role of circulating microRNAs in the pathogenesis and intestinal inflammatory activity of ulcerative colitis

Jixi Liu1,()   

  1. 1. Department of Gastroenterology, China Japan Friendship Hospital, Beijing 100029, China
  • Received:2017-07-23 Published:2017-11-26
  • Corresponding author: Jixi Liu
  • About author:
    Corresponding author: Liu Jixi, Email:
引用本文:

刘继喜. 循环microRNAs在溃疡性结肠炎发病和肠道炎症活动的作用[J]. 中华诊断学电子杂志, 2017, 05(04): 217-220.

Jixi Liu. The role of circulating microRNAs in the pathogenesis and intestinal inflammatory activity of ulcerative colitis[J]. Chinese Journal of Diagnostics(Electronic Edition), 2017, 05(04): 217-220.

溃疡性结肠炎(UC)是炎症性肠病的主要类型,发病率逐年升高,其发病机制复杂,诊断和病情评估需要依赖结肠镜检查。近年来发现microRNAs通过调节特定mRNAs的蛋白质翻译过程来调节基因的表达,参与调控细胞分化、凋亡和炎症过程,特别是组织和循环血液中microRNAs参与调节UC的发病和病情活动。部分microRNAs可能成为很有前景的UC生物标志物。

Ulcerative colitis is the main type of inflammatory bowel diseases with an increasing incidence by years.The pathogenesis is complex, its diagnosis and evaluation depend on colonoscopy.In recent years, microRNAs have been proved to be participating in regulating target mRNAs which modify gene expression, regulate cell differentiation, apoptosis and inflammation.Tissue and circulating microRNAs are found to be related to the pathogenesis and inflammatory activity of ulcerative colitis.MicroRNAs are promising biomarker in ulcerative colitis.

[1]
McCole DF.IBD candidate genes and intestinal barrier regulation[J]. Inflamm Bowel Dis, 2014, 20(10): 1829-1849.
[2]
Di Gesualdo F,Capaccioli S,Lulli M. A pathophysiological view of the long non-coding RNA world[J]. Oncotarget, 2014, 5(22): 10976-10996.
[3]
Franchi L,Warner N,Viani K, et al.Function of Nod-like receptors in microbial recognition and host defense[J]. Immunol Rev, 2009, 227(1): 106-128.
[4]
Lee J,Park EJ,Kiyono H. MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation[J]. BMB Rep, 2016, 49(5): 263-269.
[5]
Ghorpade DS,Sinha AY,Holla S, et al.NOD2-nitric oxide-responsive microRNA-146a activates Sonic hedgehog signaling to orchestrate inammatory responses in murine model of inammatory bowel disease[J]. J Biol Chem, 2013, 288(46): 33037-33048.
[6]
Polytarchou C,Hommes DW,Palumbo T, et al.MicroRNA214 is associated with progression of ulcerative colitis and inhibition reduces development of colitis and colitis associated cancer in mice[J]. Gastroenterology, 2015, 149(4): 981-992.
[7]
Wu W,He Y,Feng X, et al.MicroRNA-206 is involved in the pathogenesis of ulcerative colitis via regulation of adenosine A3 receptor[J]. Oncotarget, 2017, 8(1): 705-721.
[8]
Muljo SA,Ansel KM,Kanellopoulou C, et al.Aberrant T cell differentiation in the absence of Dicer[J]. J Exp Med, 2005, 202(2): 261-269.
[9]
Li G,Yu M,Lee WW, et al.Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity[J]. Nat Med, 2012, 18(10): 1518-1524.
[10]
Jiang S,Li C,Olive V, et al.Molecular dissection of the miR-17-92 cluster′s critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation[J]. Blood, 2011, 118(20): 5487-5497.
[11]
Kalla R,Ventham NT,Kennedy NA, et al.MicroRNAs:new players in IBD[J]. Gut, 2015, 64(3): 504-517.
[12]
Escobar TM,Kanellopoulou C,Kugler DG, et al.MiR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression[J]. Immunity, 2014, 40(6): 865-879.
[13]
Lu C,Chen J,Xu HG, et al.MiR106b and miR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagy[J]. Gastroenterology, 2014, 146(1): 188-199.
[14]
Li JA,Wang YD,Wang K, et al.Down-regulation of miR-214-3p may contribute to pathogenesis of ulcerative colitis via targeting STAT6[J]. Biomed Res Int, 2017, 2017(2): 8524972.
[15]
Koukos G,Polytarchou C,Kaplan JL, et al.MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis[J]. Gastroenterology, 2013, 145(4): 842-852.
[16]
Caruso R,Warner N,Inohara N, et al.NOD1 and NOD2:signaling, host defense, and inflammatory disease[J]. Immunity, 2014, 41(6): 898-908.
[17]
Zidar N,Boštjancˇicˇ E,Jerala M, et al.Down-regulation of microRNAs of the miR-200 family and up-regulation of Snail and Slug in inflammatory bowel diseases-hallmark of epithelial-mesenchymal transition[J]. J Cell Mol Med, 2016, 20(10): 1813-1820.
[18]
Ranjha R,Meena NK,Singh A, et al.Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs[J]. PLoS One, 2017, 12(3): e0173447.
[19]
Wu F,Zhang S,Dassopoulos T, et al.Identification of microRNAs associated with ileal and colonic Crohn’s disease[J]. Inflamm Bowel Dis, 2010, 16(10): 1729-1738.
[20]
Paraskevi A,Theodoropoulos G,Papaconstantinou I, et al.Circulating MicroRNA in inammatory bowel disease[J]. J Crohns Colitis, 2012, 6(9): 900-904.
[21]
Iborra M,Bernuzzi F,Correale C, et al.Identification of serum and tissue micro-RNA expression profiles in different stages of inflammatory bowel disease[J]. Clin Exp Immunol, 2013, 173(2): 250-258.
[22]
Krissansen GW,Yang Y,Me Queen FM, et al.Overexpression of miR-595 and miR-1246 in the sera of patients with active forms of inammatory bowel disease[J]. Inamm Bowel Dis, 2015, 21(3): 520-530.
[23]
Soubières AA,Poullis A. Emerging biomarkers for the diagnosis and monitoring of inammatory bowel diseases[J]. Inamm Bowel Dis, 2016, 22(8): 2016-2022.
[24]
Xu XM,Zhang HJ.miRNAs as new molecular insights into inflammatory bowel disease:Crucial regulators in autoimmunity and inflammation[J]. World J Gastroenterol, 2016, 22(7): 2206-2218.
[25]
Rice J,Roberts H,Burton J, et al.Assay reproducibility in clinical studies of plasma miRNA[J]. PLoS One, 2015, 10(4): e0121948.
[26]
Viennois E,Zhao Y,Han MK, et al.Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans[J]. Sci Rep, 2017, 7(1): 2520.
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