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中华诊断学电子杂志 ›› 2019, Vol. 07 ›› Issue (02) : 73 -77. doi: 10.3877/cma.j.issn.2095-655X.2019.02.001

所属专题: 文献

专题笔谈

多病种言语性幻听症状影像遗传学特征及治疗靶点模式识别的研究概况
马晓燕1, Frank Larøi2, 李猛3, Walter Martin3, 林小东4, 陈策4, 刘莎5, 徐勇5, 禚传君1,(), Steffen Gais6   
  1. 1. 300222 天津市精神卫生研究中心 天津市安定医院
    2. 4000 Lie′ge,Psychology of University of Lie′ge, University Tübingen
    3. 72076 Tübingen, Psychiatry and Psychotherapy, University Tübingen
    4. 325000 温州第七人民医院精神科
    5. 030001 太原,山西医科大学第一医院精神科
    6. Institute of Medical Psychology and Behavioral Neurobiology, University Tübingen
  • 收稿日期:2018-12-23 出版日期:2019-05-26
  • 通信作者: 禚传君
  • 基金资助:
    国家自然科学基金(81871052); 天津市自然科学基金(17JCZDJC35700); 天津市卫计委重点项目(2014KR02); 温州市科技局重点项目(ZS2017011)

A review and overview of the neuroimaging-genetics features of auditory verbal hallucinations among different mental disorders based on treatment target pattern recognition

Xiaoyan Ma1, Frank Larøi2, Meng Li3, Walter Martin3, Xiaodong Lin4, Ce Chen4, Sha Liu5, Yong Xu5, Chuanjun Zhuo1,(), Steffen Gais6   

  1. 1. Department of Psychiatry, Tianjin Mental Health Center, Tianjin Anding Hospital, Tianjin 300222, China
    2. Department of Psychology, University of Lie′ge, International Consortium on Hallucination Research, ICHR, Lie′ge 4000, Belgium
    3. Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen 72076, Germany
    4. Department of Psychiatry, Wenzhou Seventh Pepole′s Hospital, Wenzhou 325000, China
    5. Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, China
    6. Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen 72076, Germany
  • Received:2018-12-23 Published:2019-05-26
  • Corresponding author: Chuanjun Zhuo
  • About author:
    Corresponding author: Zhuo Chuanjun, Email:
引用本文:

马晓燕, Frank Larøi, 李猛, Walter Martin, 林小东, 陈策, 刘莎, 徐勇, 禚传君, Steffen Gais. 多病种言语性幻听症状影像遗传学特征及治疗靶点模式识别的研究概况[J]. 中华诊断学电子杂志, 2019, 07(02): 73-77.

Xiaoyan Ma, Frank Larøi, Meng Li, Walter Martin, Xiaodong Lin, Ce Chen, Sha Liu, Yong Xu, Chuanjun Zhuo, Steffen Gais. A review and overview of the neuroimaging-genetics features of auditory verbal hallucinations among different mental disorders based on treatment target pattern recognition[J]. Chinese Journal of Diagnostics(Electronic Edition), 2019, 07(02): 73-77.

言语性幻听(AVHs)特指在确无外界现实声音刺激的条件下,患者体验到有针对自己的"真实"声音存在,多数"声音"给患者带来精神痛苦,是高致残致死性精神症状之一;并且AVHs可出现于多种精神障碍患者中,极易导致疾病的误诊误治。因此,探寻AVHs的病理特征和精准治疗靶点已经成为当前亟需解决的问题。采用基于高通量测序的基因组学技术和基于脑影像的脑连接组学技术,探索分裂症、双相障碍、单纯抑郁、边缘型人格障碍和具有AVHs症状的健康者等6类患者AVHs症状的影像遗传学特征;并采用模式识别技术,基于上述特征,建立不同病种AVHs早期定性诊断和疗效预测体系将有助于言语性幻听的机制研究。笔者从内源性遗传特征-内表型特征(脑环路/脑网络)-表型特征(临床表现)3个角度揭示不同病种AVHs共性及特异性影像遗传学特征,以确定不同AVHs的精准治疗靶点,对建立早期诊疗预测模型、提高早期治愈率具有重要的科学意义。

Auditory verbal hallucinations (AVHs) are defined as the patients experience of the existence of "real voice" related to themselves when they were in an environment with the absence of external real voice stimulus and they are suffering from these "voice" . AVHs individuals are usually accompanied with higher disability and mortality compared to general populations. AVHs can be observed among variety of mental disorders, which subsequently cause misdiagnosis or mistreatment of diseases. Hence, it has become an urgently scientific issue to explore the pathological features and precise therapeutic targets of AVHs. Using high-throughput sequencing-based genomics technology and brain image-based brain connectome technology, we try to explore the imaging-genetic characteristics of six categories of patients with schizophrenia, bipolar disorder, unipolar depression, borderline personality disorder, and healthy individuals with AVHs symptoms. Based on these characteristics, the early qualitative diagnosis and prediction index system of AVHs of different diseases will be helpful to study the mechanism of AVHs. The future direction should focus on revealing the common and specific imaging-genetics features in different diseases from three perspectives: endogenous-genetic, endo-phenotypice (neural-circuit/brain network)-phenotypic characteristics (clinical symptoms). This can help us to explore the precise therapeutic targets of AVHs for different diseases and establish early diagnosis and treatment prediction model. These early prediction model can provide objective information to help the clinicians make precise treatment strategies for different diseases, thereby improving treatment outcomes of these dieseses.

[1]
Upthegrove R, Broome MR, Caldwell K, et al. Understanding auditory verbal hallucinations:a systematic review of current evidence[J].Acta Psychiatr Scand,2016,133(5):352-367.
[2]
Larøi F, Sommer IE, Blom JD,et al.The characteristic features of auditory verbal hallucinations in clinical and nonclinical groups:state-of-the-art overview and future directions[J].Schizophr Bull,2012,38(4):724-733.
[3]
Slotema CW, Blom JD, Niemantsverdriet MBA, et al. Auditory verbal hallucinations in borderline personality disorder and the efficacy of antipsychotics:a systematic review[J].Front Psychiatry,2018(9):347.
[4]
Toh WL, Thomas N, Rossell SL.Auditory verbal hallucinations in bipolar disorder (BD) and major depressive disorder (MDD):A systematic review[J].J Affect Disord,2015(184):18-28.
[5]
McCarthy-Jones S, Longden E.Auditory verbal hallucinations in schizophrenia and post-traumatic stress disorder:common phenomenology,common cause,common interventions?[J].Front Psychol,2015(6):1071.
[6]
Johns LC, Kompus K, Connell M,et al.Auditory verbal hallucinations in persons with and without a need for care[J].Schizophr Bull,2014(4):S255-S264.
[7]
Sommer IE, Daalman K, Rietkerk T,et al.Healthy individuals with auditory verbal hallucinations,who are they?Psychiatric assessments of a selected sample of 103 subjects[J].Schizophr Bull,2010,36(3):633-641.
[8]
Morokuma Y, Endo K, Nishida A,et al.Sex differences in auditory verbal hallucinations in early,middle and late adolescence:results from a survey of 17451 Japanese students aged 12-18 years[J].BMJ Open,2017,7(5):e015239.
[9]
Heckers S.Studies of auditory verbal hallucinations[J].Psychophysiology,2016,53(3):305-307.
[10]
Iudici A, Quarato M, Neri J.The Phenomenon of "Hearing Voices" :Not just psychotic hallucinations-a psychological literature review and a reflection on clinical and social health[J].Community Ment Health J,2018:1-8.
[11]
Sommer IE, Kleijer H, Hugdahl K.Toward personalized treatment of hallucinations[J].Curr Opin Psychiatry,2018,31(3):237-245.
[12]
Hodelet N.Psychosis and offending in British Columbia:characteristics of a secure hospital population[J].Crim Behav Ment Health,2001,11(3):163-172.
[13]
Fujita J, Takahashi Y, Nishida A,et al.Auditory verbal hallucinations increase the risk for suicide attempts in adolescents with suicidal ideation[J].Schizophr Res,2015,168(1-2):209-12.
[14]
Slotema CW, Niemantsverdriet MB, Blom JD,et al.Suicidality and hospitalisation in patients with borderline personality disorder who experience auditory verbal hallucinations[J].Eur Psychiatry,2017(41):47-52.
[15]
Waters F, Woods A, Fernyhough C.Report on the 2nd International consortiumon hallucination research:evolving directions and top-10 " hot spots" in hallucination research[J].Schizophr Bull,2014,40(1):24-27.
[16]
Hugdahl K.Auditory hallucinations:a review of the ERC "VOICE" project[J].World J Psychiatry,2015,5(2):193-209.
[17]
Lin XD, Jiang DG, Cheng LL,et al.Impaired brain white matter and functional networks in healthy individuals with auditory verbal hallucinations[J].Chin Med J(Engl),2019,132(5):606-608
[18]
Zhuo CJ.Explore the neuroimaging-genetic co-alteration features of auditory verbal hallucinations within different subjects and establish a prediction model.Brian imaging and behavior[C]//International Consortium on Hallucination Research,Japan,2018.
[19]
Steinmann S, Amselberg R, Cheng B,et al.The role of functional and structural interhemispheric auditory connectivity for language lateralization-A combined EEG and DTI study[J].Sci Rep,2018,8(1):15428.
[20]
Mallikarjun PK, Lalousis PA, Dunne TF,et al.Aberrant salience network functional connectivityin auditory verbal hallucinations:a first episode psychosis sample[J].Transl Psychiatry,2018,8(1):69.
[21]
Huang P, Cui LB, Li X,et al.Identifying first-episode drug naïve patients with schizophrenia with or without auditory verbal hallucinations using whole-brain functional connectivity:A pattern analysis study[J].Neuroimage Clin,2018(19):351-359.
[22]
Looijestijn J, Blom JD, Hoek HW,et al.Draining the pond and catching the fish:Uncovering the ecosystem of auditory verbal hallucinations[J].Neuroimage Clin,2018(20):830-843.
[23]
Pinheiro AP, Schwartze M, Kotz SA. Voice-selective prediction alterations in nonclinical voice hearers[J].Sci Rep,2018,8(1):14717.
[24]
Lin XD, Jiang DG, Cheng LL,et al.Impaired brain white matter and functional networks in healthy individuals with auditory verbal hallucinations[J].Chin Med J(Engl),2019,132(5):606-608.
[25]
Toh WL, Castle DJ, Thomas N,et al.Auditory verbal hallucinations (AVHs) and related psychotic phenomena in mood disorders:analysis of the 2010 Survey of High Impact Psychosis (SHIP) data[J].Psychiatry Res,2016(243):238-245.
[26]
Daalman K, Diederen KM, Hoekema L,et al.Five year follow-up of non-psychotic adults with frequent auditory verbal hallucinations:are they still healthy?[J].Psychol Med,2016,46(9):1897-1907.
[27]
McCarthy-Jones S, Green MJ, Scott RJ,et al.Preliminary evidence of an interaction between the FOXP2 gene and childhood emotional abuse predicting likelihoodof auditory verbal hallucinations in schizophrenia[J].J Psychiatr Res,2014(50):66-72.
[28]
Chhabra H, Shivakumar V, Subbanna M,et al.Gene polymorphisms and response to transcranial direct current stimulation for auditory verbalhallucinations in schizophrenia[J].Acta Neuropsychiatr,2018,30(4):218-225.
[29]
Zhuo CJ, Xu Y, Zhang L,et al.The effect of dopamine antagonist treatment on auditory verbal hallucinations in healthy individuals is clearly influenced by COMT genotype and accompanied by corresponding brain structural and functional alterations-an artificially controlled pilot study[J].Front Genet,2019(10):92.
[30]
Zhuo CJ, Cheng Ll, Li GY,et al.COMT-Val 158Met polymorphism modulates antipsychotic effects on auditory verbal hallucinations and temporal lobe gray matter volumes in healthy individuals-symptom relief accompanied by worrisome volume reductions[J].Brain imaging and behavior,2019:1-9.
[31]
Sommer IE, Kleijer H, Hugdahl K.Toward personalized treatment of hallucinations[J].Curr Opin Psychiatry,2018,31(3):237-245.
[32]
Xia M, He Y.Functional connectomics from a "big data" perspective[J].Neuroimage,2017(160):152-167.
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