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中华诊断学电子杂志 ›› 2019, Vol. 07 ›› Issue (02) : 83 -86. doi: 10.3877/cma.j.issn.2095-655X.2019.02.003

所属专题： 文献；

认知功能障碍

高压氧治疗对阿尔茨海默病患者认知功能及血清Humanin水平的影响
徐玉振1, 王茜2, 单敏1, 王涛1, 杨位霞3, 张新萍1,†()   
  1. 1. 271000　泰安市中心医院神经内科
    2. 271000　泰安市中心医院中心实验室
    3. 201700　上海，复旦大学附属中山医院青浦分院神经内科
  • 收稿日期:2018-11-15 出版日期:2019-05-26
  • 通信作者: 张新萍
  • 基金资助:
    山东省保健科技协会课题(SDBJKT20180030); 泰安市科技发展计划(2017NS0155)

Effect of hyperbaric oxygen therapy on cognitive function and serum Humanin level in patients with Alzheimer′s disease

Yuzhen Xu1, Qian Wang2, Min Shan1, Tao Wang1, Weixia Yang3, Xinping Zhang1,†()   

  1. 1. Department of Neurology, Taian City Central Hospital, Taian 271000, China
    2. Department of Central Laboratory, Taian City Central Hospital, Taian 271000, China
    3. Department of Neurology, Zhongshan Hospital, Qingpu Branch, Shanghai 201700, China
  • Received:2018-11-15 Published:2019-05-26
  • Corresponding author: Xinping Zhang
  • About author:
    Corresponding author: Zhang Xinping, Email:
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徐玉振, 王茜, 单敏, 王涛, 杨位霞, 张新萍. 高压氧治疗对阿尔茨海默病患者认知功能及血清Humanin水平的影响[J]. 中华诊断学电子杂志, 2019, 07(02): 83-86.

Yuzhen Xu, Qian Wang, Min Shan, Tao Wang, Weixia Yang, Xinping Zhang. Effect of hyperbaric oxygen therapy on cognitive function and serum Humanin level in patients with Alzheimer′s disease[J]. Chinese Journal of Diagnostics(Electronic Edition), 2019, 07(02): 83-86.

目的

探讨高压氧(HBO)治疗对阿尔茨海默病(AD)患者认知功能及血清Humanin水平的影响。

方法

选取2015年6月至2017年6月在泰安市中心医院神经内科住院的轻中度AD患者，共72例，采用随机数字表法随机分为对照组和HBO治疗组，每组各36例。对照组给予常规治疗，HBO治疗组在对照组的基础上给予HBO治疗，两组疗程均为2个月。比较两组患者治疗前后简易精神量表(MMSE)评分、蒙特利尔认知量表(MoCA)评分及血清Humanin水平变化情况。

结果

治疗前，对照组MMSE评分、MoCA评分及血清Humanin水平分别为(15.35±2.12)分，(17.08±2.73)分，(147.2±39.6)ng/L；HBO治疗组MMSE评分、MoCA评分及血清Humanin水平分别为(15.29±2.43)分，(17.16±2.61)分，(141.8±41.3)ng/L，两组比较均差异无统计学意义(t＝0.11, －0.13, 0.57；均P>0.05)；治疗2个月后，对照组MMSE评分、MoCA评分及血清Humanin水平分别为(18.57±3.59)分，(20.46±3.07)分，(180.9±48.1)ng/L，低于HBO治疗组[(20.68±2.97)分，(22.74±3.28)分，(216.5±52.9)ng/L]，差异具有统计学意义(t＝－2.72, －3.05, －2.99；均P<0.01)；血清Humanin水平与MMSE评分、MoCA评分均呈正相关(r＝0.628，0.691；均P<0.05)。

结论

HBO可改善AD患者的认知功能，其作用机制可能与升高血清Humanin的水平有关。

关键词: 阿尔茨海默病, 高压氧, 认知, Humanin
Objective

To investigate the effect of hyperbaric oxygen (HBO) on cognitive function and serum Humanin expression in patients with Alzheimer′s disease (AD).

Methods

From June 2015 to June 2017, 72 patients with mild to moderate AD admitted to the Neurology of Taian Central Hospital were selected. The patients were divided into control group and HBO treatment group by random number table method, each group with 36 patients. The control group was given conventional treatments and HBO treatment group was treated with HBO based on the conventional treatments, both groups were treated for 2 months. Mini-mental state examination (MMSE) scores, Montreal Cognitive Assessment (MoCA)scores and serum levels of Humanin in the two groups were compared before and after treatment.

Results

Before treatment, the MMSE score, MoCA score and serum Humanin level of the control group were (15.35±2.12) points, (17.08±2.73) points, (147.2±39.6) ng/L, respectively. The MMSE score, MoCA score and serum Humanin level in the HBO treatment group were (15.29±2.43) points, (17.16±2.61) points, (141.8±41.3) ng/L, respectively, there were no significant differences between the two groups (t=0.11, -0.13, 0.57, all P>0.05). After treatment, the MMSE score, MoCA score and serum Humanin level of the control group were (18.57±3.59)points, (20.46±3.07)points, (180.9±48.1)ng/L, which were lower than those in the HBO treatment group [(20.68±2.97)points, (22.74±3.28)points, (216.5±52.9)ng/L, respectively], the differences were significant (t=-2.72, -3.05, -2.99, all P<0.01). Serum Humanin level was positively correlated with MMSE score (r=0.628, P<0.05), and MoCA score (r=0.691, P<0.05).

Conclusion

Hyperbaric oxygen can improve the cognitive function of AD patients, and the mechanism may be related to the increased serum levels of Humanin.

Key words: Alzheimer disease, Hyperbaric oxygen, Cognition, Humanin
表1 两组AD患者治疗前后MMSE及MoCA评分比较(分，±s)
组别 例数 MMSE MoCA
治疗前 治疗2个月后 治疗前 治疗2个月后
对照组 36 15.35±2.12 18.57±3.59 17.08±2.73 20.46±3.07
治疗组 36 15.29±2.43 20.68±2.97 17.16±2.61 22.74±3.28
t值 ? 0.11 －2.72 －0.13 －3.05
P值 ? 0.911 0.008 0.899 0.003
表2 两组AD患者治疗前后血清Humanin水平比较(ng/L，±s)
组别 例数 治疗前 治疗2个月后
对照组 36 147.21±39.63 180.97±48.10
治疗组 36 141.86±41.32 216.58±52.95
t值 ? 0.57 －2.99
P值 ? 0.573 0.004
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