切换至 "中华医学电子期刊资源库"

中华诊断学电子杂志 ›› 2019, Vol. 07 ›› Issue (02) : 83 -86. doi: 10.3877/cma.j.issn.2095-655X.2019.02.003

所属专题: 文献

认知功能障碍

高压氧治疗对阿尔茨海默病患者认知功能及血清Humanin水平的影响
徐玉振1, 王茜2, 单敏1, 王涛1, 杨位霞3, 张新萍1,()   
  1. 1. 271000 泰安市中心医院神经内科
    2. 271000 泰安市中心医院中心实验室
    3. 201700 上海,复旦大学附属中山医院青浦分院神经内科
  • 收稿日期:2018-11-15 出版日期:2019-05-26
  • 通信作者: 张新萍
  • 基金资助:
    山东省保健科技协会课题(SDBJKT20180030); 泰安市科技发展计划(2017NS0155)

Effect of hyperbaric oxygen therapy on cognitive function and serum Humanin level in patients with Alzheimer′s disease

Yuzhen Xu1, Qian Wang2, Min Shan1, Tao Wang1, Weixia Yang3, Xinping Zhang1,()   

  1. 1. Department of Neurology, Taian City Central Hospital, Taian 271000, China
    2. Department of Central Laboratory, Taian City Central Hospital, Taian 271000, China
    3. Department of Neurology, Zhongshan Hospital, Qingpu Branch, Shanghai 201700, China
  • Received:2018-11-15 Published:2019-05-26
  • Corresponding author: Xinping Zhang
  • About author:
    Corresponding author: Zhang Xinping, Email:
引用本文:

徐玉振, 王茜, 单敏, 王涛, 杨位霞, 张新萍. 高压氧治疗对阿尔茨海默病患者认知功能及血清Humanin水平的影响[J/OL]. 中华诊断学电子杂志, 2019, 07(02): 83-86.

Yuzhen Xu, Qian Wang, Min Shan, Tao Wang, Weixia Yang, Xinping Zhang. Effect of hyperbaric oxygen therapy on cognitive function and serum Humanin level in patients with Alzheimer′s disease[J/OL]. Chinese Journal of Diagnostics(Electronic Edition), 2019, 07(02): 83-86.

目的

探讨高压氧(HBO)治疗对阿尔茨海默病(AD)患者认知功能及血清Humanin水平的影响。

方法

选取2015年6月至2017年6月在泰安市中心医院神经内科住院的轻中度AD患者,共72例,采用随机数字表法随机分为对照组和HBO治疗组,每组各36例。对照组给予常规治疗,HBO治疗组在对照组的基础上给予HBO治疗,两组疗程均为2个月。比较两组患者治疗前后简易精神量表(MMSE)评分、蒙特利尔认知量表(MoCA)评分及血清Humanin水平变化情况。

结果

治疗前,对照组MMSE评分、MoCA评分及血清Humanin水平分别为(15.35±2.12)分,(17.08±2.73)分,(147.2±39.6)ng/L;HBO治疗组MMSE评分、MoCA评分及血清Humanin水平分别为(15.29±2.43)分,(17.16±2.61)分,(141.8±41.3)ng/L,两组比较均差异无统计学意义(t=0.11, -0.13, 0.57;均P>0.05);治疗2个月后,对照组MMSE评分、MoCA评分及血清Humanin水平分别为(18.57±3.59)分,(20.46±3.07)分,(180.9±48.1)ng/L,低于HBO治疗组[(20.68±2.97)分,(22.74±3.28)分,(216.5±52.9)ng/L],差异具有统计学意义(t=-2.72, -3.05, -2.99;均P<0.01);血清Humanin水平与MMSE评分、MoCA评分均呈正相关(r=0.628,0.691;均P<0.05)。

结论

HBO可改善AD患者的认知功能,其作用机制可能与升高血清Humanin的水平有关。

Objective

To investigate the effect of hyperbaric oxygen (HBO) on cognitive function and serum Humanin expression in patients with Alzheimer′s disease (AD).

Methods

From June 2015 to June 2017, 72 patients with mild to moderate AD admitted to the Neurology of Taian Central Hospital were selected. The patients were divided into control group and HBO treatment group by random number table method, each group with 36 patients. The control group was given conventional treatments and HBO treatment group was treated with HBO based on the conventional treatments, both groups were treated for 2 months. Mini-mental state examination (MMSE) scores, Montreal Cognitive Assessment (MoCA)scores and serum levels of Humanin in the two groups were compared before and after treatment.

Results

Before treatment, the MMSE score, MoCA score and serum Humanin level of the control group were (15.35±2.12) points, (17.08±2.73) points, (147.2±39.6) ng/L, respectively. The MMSE score, MoCA score and serum Humanin level in the HBO treatment group were (15.29±2.43) points, (17.16±2.61) points, (141.8±41.3) ng/L, respectively, there were no significant differences between the two groups (t=0.11, -0.13, 0.57, all P>0.05). After treatment, the MMSE score, MoCA score and serum Humanin level of the control group were (18.57±3.59)points, (20.46±3.07)points, (180.9±48.1)ng/L, which were lower than those in the HBO treatment group [(20.68±2.97)points, (22.74±3.28)points, (216.5±52.9)ng/L, respectively], the differences were significant (t=-2.72, -3.05, -2.99, all P<0.01). Serum Humanin level was positively correlated with MMSE score (r=0.628, P<0.05), and MoCA score (r=0.691, P<0.05).

Conclusion

Hyperbaric oxygen can improve the cognitive function of AD patients, and the mechanism may be related to the increased serum levels of Humanin.

表1 两组AD患者治疗前后MMSE及MoCA评分比较(分,±s)
表2 两组AD患者治疗前后血清Humanin水平比较(ng/L,±s)
[1]
Hung AS, Liang Y, Chow TC, et al. Mutated tau,amyloid and neuroinflammation in Alzheimer disease-A brief review[J].Prog in Histochem Cytochem,2016,51(1):1-8.
[2]
Wolters FJ, Koudstaal PJ, Hofman A,et al.Serum apolipoprotein E is associated with long-term risk of Alzheimer′s disease:the rotterdam study[J].Neurosci Lett,2016(617):139-142.
[3]
Kumar A, Singh A, Ekavali.A review on Alzheimer′s disease pathophysiology and its management:an update[J].Pharmacol Rep,2015,67(2):195-203.
[4]
杨鹏,岳阳,周效宝,等.阿尔茨海默病患者脑电功率值特征分析[J/CD].中华诊断学电子杂志,2015,3(1):36-40.
[5]
Boussi-Gross R, Golan H, Volkov O,et al.Improvement of memory impairments in poststroke patients by hyperbaric oxygen therapy[J].Neuropsychology,2015,29(4):610-621.
[6]
Matsuoka M. Protective effects of Humanin and calmodulin-like skin protein in Alzheimer′s disease and broad range of abnormalities[J].Mol Neurobiol,2015,51(3):1232-1239.
[7]
Association AP.Diagnostic and statistical manual of mental disorders (DSM-5®)[M] .Washington:American Psychiatric Pub,2013:611-614.
[8]
Dubois B, Feldman HH, Jacova C,et al.Research criteria for the diagnosis of Alzheimer′s disease:revising the NINCDS-ADRDA criteria[J].Lancet Neurol,2007,6(8):734-746.
[9]
李伟,肖世富.阿尔茨海默病诊断标准的演变及评价[J/CD].中华诊断学电子杂志,2015,3(2):114-117.
[10]
贾阳娟,韩凝,王美蓉,等.MoCA与MMSE在急性缺血性卒中后认知障碍评估中的应用[J].中华行为医学与脑科学杂志,2017,26(1):46-50.
[11]
Mittal K, Katare DP.Shared links between type 2 diabetes mellitus and Alzheimer′s disease:A review[J].Diabetes Metab Syndr,2016,10(2 Suppl 1):S144-S149.
[12]
Alzheiner′s Association.2017 Alzheimer′s disease facts and figures[J].Alzheimer′s & Dementia,2017,13(4):325-373.
[13]
Shapira R, Solomon B, Efrati S,et al. Hyperbaric oxygen therapy ameliorates pathophysiology of 3xTg-AD mouse model by attenuating neuroinflammation[J].Neurobiol Aging,2018(62):105-119.
[14]
Zhao BS, Pan YY, Wang ZY,et al.Hyperbaric oxygen pretreatment improves cognition and reduces hippocampal damage via p38 mitogen-activated protein kinase in a rat model[J]. Yonsei Med J,2017,58(1):131-138.
[15]
王晖霖,唐建梅.高压氧对阿尔茨海默病患者血清雌激素水平的影响[J].中国医药导报,2011,8(5):26-28.
[16]
高聚,姜华,宛丰,等.高压氧联合多奈哌齐治疗阿尔茨海默病的疗效及对血清内皮素-1的影响[J]. 神经损伤与功能重建,2017,12(3):269-271.
[17]
Gong Z, Tas E, Muzumdar R.Humanin and age-related diseases:a new link?[J].Front Endocrinol (Lausanne),2014(5):210.
[18]
Zhang XP, Zhang QL, Du YF.A novel rattin expression in the brain of the rat model of patients′ vascular dementia[J].J Neurol Sci Neurophysiol,2013,30(2):249-256.
[19]
Liu W, Zhang XP, Yang DL,et al.Humanin attenuated the change of voltage-dependent potassium currents in hippocampal neurons induced by anoxia[J].CNS Neurosci Ther,2014,20(1):95-97.
[20]
Han K, Jia N, Zhong Y, et al. S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse[J].J Cell Biochem,2018,119(4):3111-3117.
[21]
Alam MP, Bilousova T, Spilman P,et al.A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity[J].ACS Chem Neurosci,2018,9(3):462-468.
[22]
Cui AL, Zhang YH, Li JZ, et al. Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction[J].Drug Des Devel Ther,2017(11):1243-1253.
[1] 孔令梅, 徐晓媛, 马丽颖. 慢性阻塞性肺疾病认知衰弱危险因素及预后分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(03): 407-410.
[2] 张骞, 唐伟, 刘丽丽. 右美托咪定复合羟考酮对老年经皮椎间孔镜腰椎间盘切除术患者术后认知功能、镇痛效果的影响[J/OL]. 中华老年骨科与康复电子杂志, 2024, 10(04): 209-214.
[3] 吉莉, 苏云楠, 王斌, 沈滔, 刘团结, 毛蕾, 徐玉萍, 张婷, 王博. 急性缺血性脑卒中患者脑白质微结构改变对长期认知功能损伤的预测价值研究[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(04): 193-200.
[4] 杨森, 阙玉梅, 丁莉, 王艺瑾, 侯庆宇. Hcy和AD7c-NTP在阿尔茨海默病诊断中的临床应用[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(04): 208-212.
[5] 李苒, 姜宇航, 陈泽浩, 何家恺, 闫珊珊, 鄢锦荣, 贾宝辉. 电针治疗阿尔茨海默病患者的先导性随机对照试验[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(04): 218-224.
[6] 王江波, 尹一鸣, 张冠群. 外周血生物标志物在阿尔茨海默病早期诊断中的价值[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(04): 244-249.
[7] 刘霖, 张文欢, 宋雅茹, 姜云璐. Apelin-13 在阿尔茨海默病中的神经保护作用机制研究进展[J/OL]. 中华诊断学电子杂志, 2024, 12(04): 276-280.
[8] 孙琴, 梁钿苑, 张源, 任亦星. 代谢异常型肥胖患者对肥胖和减重手术的认知调查研究[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(04): 295-299.
[9] 高昊雯, 王桂琦, 庞利云, 张新昕, 谷敬锋. 减重手术治疗肥胖症相关认知障碍的研究进展[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(03): 206-212.
[10] 欧春影, 李晓宾, 郭靖, 朱亮, 许可, 王梦, 安晓雷. 丁苯酞对血管性认知障碍大鼠炎症因子的影响及对认知障碍的改善作用[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 483-487.
[11] 王丽娜, 吕书霞, 李亚男. 脑卒中偏瘫患者健康焦虑元认知与疾病接受度、恐惧疾病进展的相关性[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 434-440.
[12] 克地尔牙·马合木提, 胡波, 杨琼, 闫素, 胡岚卿, 高沛沛, 姚恩生. 依达拉奉右莰醇对急性脑梗死后认知功能障碍的疗效观察[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 459-466.
[13] 董立羚, 王添艺, 毛晨晖, 姜宇涵, 尚丽, 包嘉璐, 仇宇悦, 褚珊珊, 金蔚, 倪俊, 高晶. 非出血型脑淀粉样血管病的认知特征——来自北京协和医院痴呆队列的数据[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(04): 295-300.
[14] 董坤, 陈海恋, 王景. 血清CircRNA_0003694与老年急性缺血性卒中患者卒中后认知损害的关系[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(03): 230-235.
[15] 欧春影, 李晓宾, 郭靖, 许可, 王梦, 安晓雷. hs-CRP、Lp-PLA2和S100β与缺血性脑小血管病患者认知障碍的相关性[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(03): 265-269.
阅读次数
全文


摘要