切换至 "中华医学电子期刊资源库"

中华诊断学电子杂志 ›› 2024, Vol. 12 ›› Issue (04) : 276 -280. doi: 10.3877/cma.j.issn.2095-655X.2024.04.012

综述

Apelin-13 在阿尔茨海默病中的神经保护作用机制研究进展
刘霖1,2, 张文欢1,2, 宋雅茹1,2, 姜云璐1,()   
  1. 1.272067 济宁医学院神经生物学研究所
    2.272067 济宁医学院基础医学院
  • 收稿日期:2024-05-23 出版日期:2024-11-26
  • 通信作者: 姜云璐
  • 基金资助:
    山东省大学生创新训练计划项目(S202210443021,S202410443001,S202410443040)济宁医学院校级大学生创新训练计划项目(cx2022027z,cx2022129z)

Research advances of the neuroprotective mechanism of apelin-13 in Alzheimer disease

Lin Liu1,2, Wenhuan Zhang1,2, Yaru Song1,2, Yunlu Jiang1,()   

  1. 1.Department of Neurobiology
    2.College of Basic Medical,Jining Medical University,Jining 272067,China
  • Received:2024-05-23 Published:2024-11-26
  • Corresponding author: Yunlu Jiang
引用本文:

刘霖, 张文欢, 宋雅茹, 姜云璐. Apelin-13 在阿尔茨海默病中的神经保护作用机制研究进展[J]. 中华诊断学电子杂志, 2024, 12(04): 276-280.

Lin Liu, Wenhuan Zhang, Yaru Song, Yunlu Jiang. Research advances of the neuroprotective mechanism of apelin-13 in Alzheimer disease[J]. Chinese Journal of Diagnostics(Electronic Edition), 2024, 12(04): 276-280.

阿尔茨海默病(AD)是目前无法治愈且发病率较高的神经退行性疾病,严重威胁着老年人的生活质量和寿命。据统计,全球范围内AD 的患病率逐年上升,且AD 发病机制复杂,至今尚无有效的治疗方法。近年研究表明,生物活性肽对AD 具有神经保护作用。Apelin-13 是一种广泛分布于中枢神经系统神经元和少突胶质细胞的神经肽,参与记忆学习过程和预防神经损伤。研究表明,apelin-13 可以直接或间接阻止β 淀粉样蛋白的产生、抑制磷酸化Tau 蛋白的积累、抗炎、抗凋亡,以及通过调节自噬等减缓AD 发生进程。笔者主要对apelin-13 在AD 中保护作用机制的最新研究进展进行综述,为AD 的预防和治疗提供新的思路。

Alzheimer disease (AD) is a currently incurable neurodegenerative disease with a high incidence rate,which seriously threatens the life quality and lifespan of the eldly.According to statistics,the worldwide incidence of AD worldwide is increasing year by year,and the pathogenesis of AD is complex,with no effective treatment method available to date.Recent studies have shown that bioactive peptides have neuroprotective effects on AD.Apelin-13 is an endogenous neuropeptide,which is widely distributed in neurons and oligodendrocytes of the central nervous system,participating in the processes of memory and learning as well as the prevention of neuronal damage.Studies have shown that apelin-13 can directly or indirectly prevent the production of amyloid-β,inhibit the accumulation of phosphorylated Tau protein,exhibit anti-inflammatory and anti-apoptotic effects,as well s modulate autophagy proless,to slow down the progression of AD.The review mainly focuses on the latest research progress on the protective mechanism of apelin-13 in AD,providing new ideas for the prevention and treatment of AD.

表1 Apelin 在阿尔茨海默病中的作用
[1]
崔慧娟,苏雪,马清清,等.维甲酸类化合物在AD 防治中的作用机制研究进展[J].中华神经医学杂志,2022,21(11):1184-1188.DOI:10.3760/cma.j.cn115354-20220521-00355.
[2]
Scheltens P,De Strooper B,Kivipelto M,et al.Alzheimer′s disease[J].Lancet,2021,397(10284):1577-1590.DOI:10.1016/S0140-6736(20)32205-4.
[3]
2024 Alzheimer′s disease facts and figures [J].Alzheimers Dement,2024,20(5):3708-3821.DOI:10.1002/alz.13809.
[4]
Vaz M,Silvestre S.Alzheimer′s disease:recent treatment strategies[J].Eur J Pharmacol,2020(887):173554.DOI:10.1016/j.ejphar.2020.173554.
[5]
Wan T,Fu M,Jiang Y,et al.Research progress on mechanism of neuroprotective roles of apelin-13 in prevention and treatment of Alzheimer′s disease[J].Neurochem Res,2022,47(2):205-217.DOI:10.1007/s11064-021-03448-1.
[6]
Sasaki K,Yamano Y,Bardhan S,et al.Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin Ⅱtype-1 receptor[J].Nature,1991,351(6323):230-233.DOI:10.1038/351230a0.
[7]
Fiona AC,Janet JM,David EN,et al.Targeting the apelin system for the treatment of cardiovascular diseases [J].Cardiovasc Res,2023,119(17):2683-2696.DOI:10.1093/cvr/cvad171.
[8]
Wei MH,Wu T,Chen N.Bridging neurotrophic factors and bioactive peptides to Alzheimer′s disease [J].Ageing Res Rev,2024(94):102177.DOI:10.1016/j.arr.2023.102177.
[9]
Peng QM,Zhou JH,Xu ZW,et al.Apelin-13 ameliorates LPS induced BV-2 microglia inflammatory response through promoting autophagy and inhibiting H3K9ac enrichment of TNF-α and IL-6 promoter [J].Acta Neurobiol Exp (Wars),2022,82(1):65-76.DOI:10.55782/ane-2022-006.
[10]
Yoshiya S,Shirabe K,Imai D,et al.Blockade of the apelin-APJ system promotes mouse liver regeneration by activating Kupffer cells after partial hepatectomy[J].J Gastroenterol,2015,50 (5):573-582.DOI:10.1007/s00535-014-0992-5.
[11]
Chen B,Wu JW,Hu S,et al.Apelin-13 improves cognitive impairment and repairs hippocampal neuronal damage by activating PGC-1α/PPARγ signaling[J].Neurochem Res,2023,48(5):1504-1515.DOI:10.1007/s11064-022-03844-1.
[12]
Luo HQ,Xiang Y,Qu XP,et al.Apelin-13 suppresses neuroinflammation against cognitive deficit in a streptozotocin-induced rat model of Alzheimer′s disease through activation of BDNF-TrkB signaling pathway[J].Front Pharmacol,2019(10):395.DOI:10.3389/fphar.2019.00395.
[13]
Luo HQ,Han L,Xu J,et al.Apelin/APJ system:a novel promising target for neurodegenerative diseases[J].J Cell Physiol,2020,235(2):638-657.DOI:10.1002/jcp.29001.
[14]
Zhou SH,Guo XX,Chen SS,et al.Apelin-13 regulates LPSinduced N9 microglia polarization involving STAT3 signaling pathway[J].Neuropeptides,2019(76):101938.DOI:10.1016/j.npep.2019.101938.
[15]
Wu S,Chen NJ,Wang CC.Frontiers and hotspots evolution in antiinflammatory studies for Alzheimer′s disease [J].Behav Brain Res,2024(472):115178.DOI:10.1016/j.bbr.2024.115178.
[16]
Reading CL,Ahlem CN,Murphy MF.NM101 phase Ⅲ study of NE3107 in Alzheimer′s disease:rationale,design and therapeutic modulation of neuroinflammation and insulin resistance[J].Neurodegener Dis Manag,2021,11(4):289-298.DOI:10.2217/nmt-2021-0022.
[17]
Andra LT,Carl WC.Emerging roles of oxidative stress in brain aging and Alzheimer′s disease [J].Neurobiol Aging,2021(107):86-95.DOI:10.1016/j.neurobiolaging.
[18]
Zhang P,Yi LH,Meng GY,et al.Apelin-13 attenuates cisplatininduced cardiotoxicity through inhibition of ROS-mediated DNA damage and regulation of MAPKs and AKT pathways[J].Free Radic Res,2017,51(5):449-459.DOI:10.1080/10715762.2017.1313414.
[19]
Yildiz Z,Eren N,Orcun A,et al.Serum apelin-13 levels and total oxidant/antioxidant status of patients with Alzheimer′s disease[J].Aging Med (Milton),2021,4(3):201-205.DOI:10.1002/agm2.12173.
[20]
Samandari-Bahraseman MR,Elyasi L.Apelin-13 protects human neuroblastoma SH-SY5Y cells against amyloid-beta induced neurotoxicity: involvement of anti oxidant and anti apoptotic properties[J].J Basic Clin Physiol Pharmacol,2022,33(5):599-605.DOI:10.1515/jbcpp-2020-0294.
[21]
Moriyama M,Moriyama H,Uda J,et al.BNIP3 upregulation via stimulation of ERK and JNK activity is required for the protection of keratinocytes from UVB-induced apoptosis[J].Cell Death Dis,2017,8(2):e2576.DOI:10.1038/cddis.2017.4.
[22]
Xu RR,Liu YL,Hao M,et al.Apelin-36 alleviates LPS-induced trophoblast cell injury by inhibiting GRP78/ASK1/JNK signaling[J].Tissue Cell,2023(82):102057.DOI:10.1016/j.tice.2023.102057.
[23]
Salminen A,Kaarniranta K,Kauppinen A,et al.Impaired autophagy and APP processing in Alzheimer′s disease:the potential role of Beclin 1 interactome[J].Prog Neurobiol,2013(106-107):33-54.DOI:10.1016/j.pneurobio.2013.06.002.
[24]
Gong G,Wan WH,Liu XH,et al.Apelin-13,a regulator of autophagy,apoptosis and inflammation in multifaceted bone protection [J].Int Immunopharmacol,2023(117):109991.DOI:10.1016/j.intimp.2023.109991.
[25]
Hou X,Zeng H,Tuo QH,et al.Apelin gene therapy increases autophagy via activation of sirtuin 3 in diabetic heart[J].Diabetes Res (Fairfax),2015,1(4):84-91.DOI:10.17140/DROJ-1-115.
[26]
Aminyavari S,Zahmatkesh M,Farahmandfar M,et al.Protective role of apelin-13 on amyloid β25-35-induced memory deficit;Involvement of autophagy and apoptosis process[J].Prog Neuropsychopharmacol Biol Psychiatry,2019(89):322-334.DOI:10.1016/j.pnpbp.2018.10.005.
[27]
Haeberlein SB,Aisen PS,Barkhof F,et al.Two randomized phase 3 studies of aducanumab in early Alzheimer′s disease[J].J Prev Alzheimers Dis,2022,9(2):197-210.DOI:10.14283/jpad.2022.30.
[28]
Wischik CM,Bentham P,Gauthier S,et al.Oral Tau aggregation inhibitor for Alzheimer′s disease:design,progress and basis for selection of the 16 mg/day dose in a phase 3,randomized,placebocontrolled trial of hydromethylthionine mesylate [ J].J Prev Alzheimers Dis,2022,9(4):780-790.DOI:10.14283/jpad.2022.63.
[29]
Wang C,Liu N,Luan RH,et al.Apelin protects sarcoplasmic reticulum function and cardiac performance in ischaemia-reperfusion by attenuating oxidation of sarcoplasmic reticulum Ca2+-ATPase and ryanodine receptor[J].Cardiovasc Res,2013,100(1):114-124.DOI:10.1093/ cvr/cvt160.
[30]
Complementary EB,Medicine A.Retracted:regulation of apelin-13 on Bcl-2 and Caspase-3 and its effects on adipocyte apoptosis[J].Evid Based Complement Alternat Med,2023(2023):9762535.DOI:10.1155/2023/9762535.
[31]
Kurz C,Walker L,Rauchmann BS,et al.Dysfunction of the bloodbrain barrier in Alzheimer′s disease:evidence from human studies[J].Neuropathol Appl Neurobiol,2022,48 (3):e12782.DOI:10.1111/nan.12782.
[32]
Cheng J,Luo XL,Huang Z,et al.Apelin/APJ system:a potential therapeutic target for endothelial dysfunction-related diseases[J].J Cell Physiol,2019,234(8):12149-12160.DOI:10.1002/jcp.27942.
[33]
Hall C,Ehrlich L,Venter J,et al.Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth [J].Cancer Lett,2017(386):179-188.DOI:10.1016/j.canlet.2016.11.025.
[34]
Chu HL,Yang XB,Huang CY,et al.Apelin-13 protects against ischemic blood-brain barrier damage through the effects of aquaporin-4[J].Cerebrovasc Dis,2017,44(1/2):10-25.DOI:10.1159/000460261.
[35]
Yildiz Z,Eren N,Orcun A,et al.Serum apelin-13 levels and total oxidant/antioxidant status of patients with Alzheimer′s disease[J].Aging Med (Milton),2021,4(3):201-205.DOI:10.1002/agm2.12173.
[36]
Acikel SB,Artik A,Hosoglu E,et al.Serum apelin-13 levels are decreased among adolescents diagnosed with major depressive disorder[J].Psychiatr Danub,2022,34(4):677-681.DOI:10.24869/psyd.2022.677.
[1] 王振宇, 张洪美, 荆琳, 何名江, 闫奇. 膝骨关节炎相关炎症因子与血浆代谢物间的因果关系及中介效应[J]. 中华损伤与修复杂志(电子版), 2024, 19(06): 467-473.
[2] 李争光, 宰爽嘉, 吴火峰, 孙华, 张永博, 陈浏阳, 戴睿, 张亮. 昼夜节律相关因子在椎间盘退行性变发病机制中作用的研究进展[J]. 中华损伤与修复杂志(电子版), 2024, 19(05): 457-461.
[3] 唐梅, 周丽, 牛岑月, 周小童, 王倩. ICG荧光导航的腹腔镜肝切除术临床意义[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 655-658.
[4] 付成旺, 杨大刚, 王榕, 李福堂. 营养与炎症指标在可切除胰腺癌中的研究进展[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 704-708.
[5] 杜贵伟, 陆勇, 成博, 贺薏, 梁爽. 钬激光碎石术术后联合坦索罗辛治疗对输尿管结石患者的影响分析[J]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 491-496.
[6] 郑俊, 吴杰英, 谭海波, 郑安全, 李腾成. EGFR-MEK-TZ三联合分子的构建及其对去势抵抗性前列腺癌细胞增殖与凋亡的影响[J]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 503-508.
[7] 胡思平, 熊性宇, 徐航, 杨璐. 衰老相关分泌表型因子在前列腺癌发生发展中的作用机制[J]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 425-434.
[8] 邢嘉翌, 龚佳晟, 祝佳佳, 陆群. 肺癌化疗患者继发肺部感染的病原菌耐药性及炎症因子变化分析[J]. 中华肺部疾病杂志(电子版), 2024, 17(05): 714-718.
[9] 李智, 冯芸. NF-κB 与MAPK 信号通路及其潜在治疗靶点在急性呼吸窘迫综合征中的研究进展[J]. 中华肺部疾病杂志(电子版), 2024, 17(05): 840-843.
[10] 杜霞, 马梦青, 曹长春. 造影剂诱导的急性肾损伤的发病机制及干预靶点研究进展[J]. 中华肾病研究电子杂志, 2024, 13(05): 279-282.
[11] 陈利, 杨长青, 朱风尚. 重视炎症性肠病和代谢相关脂肪性肝病间的串话机制研究[J]. 中华消化病与影像杂志(电子版), 2024, 14(05): 385-389.
[12] 杭丽, 张耀辉, 孙文恺. 参菝抗瘤液对结直肠腺瘤性息肉术后肠道功能、炎症指标及复发情况的影响[J]. 中华消化病与影像杂志(电子版), 2024, 14(05): 413-416.
[13] 丛黎, 马林, 陈旭, 李文文, 张亮亮, 周华亭. 改良CT严重指数联合炎症指标在重症急性胰腺炎患者胰腺感染预测及预后评估中的研究[J]. 中华消化病与影像杂志(电子版), 2024, 14(05): 432-436.
[14] 靳英, 付小霞, 陈美茹, 袁璐, 郝力瑶. CD147调控MAPK信号通路对结肠癌细胞增殖和凋亡的影响及机制研究[J]. 中华临床医师杂志(电子版), 2024, 18(05): 474-480.
[15] 牟磊, 徐东成, 韩鑫, 徐长江, 韩坤锜, 薛叶潇, 牟媛, 秦文玲, 刘相静, 陈哲, 高楠. 五虫通络胶囊防治椎动脉开口支架术后再狭窄发生的效果[J]. 中华脑血管病杂志(电子版), 2024, 18(05): 467-472.
阅读次数
全文


摘要