特发性多中心型Castleman病的诊断学特征并文献复习

doi:10.3877/cma.j.issn.2095-655X.2022.01.013

中华诊断学电子杂志 ›› 2022, Vol. 10 ›› Issue (01) : 63 -66. doi: 10.3877/cma.j.issn.2095-655X.2022.01.013

病例诊断思维

特发性多中心型Castleman病的诊断学特征并文献复习

杜鹏宇¹, 朱红红²^,^†(

), 孙冰³, 冉启玉¹, 孔蕾¹

^1. 272013　济宁医学院临床医学院
^2. 272029　济宁医学院附属医院急诊科
^3. 272013　济宁医学院中西医结合学院

收稿日期:2021-10-16 出版日期:2022-02-26
通信作者: 朱红红

Diagnostic features of idiopathic multicentric Castleman disease and literature review

Pengyu Du¹, Honghong Zhu²^,^†(), Bing Sun³, Qiyu Ran¹, Lei Kong¹

^1. Clinical Medical College, Jining Medical University, Jining 272013, China
^2. Department of Emergency, Affiliated Hospital of Jining Medical University, Jining 272029, China
^3. College of Integrated Traditional Chinese and Western Medicine, Jining Medical University, Jining 272013, China

Received:2021-10-16 Published:2022-02-26
Corresponding author: Honghong Zhu

全文 ( ) 下载PDF ( ) 导出引用

目的

探讨特发性多中心型Castleman病的诊断学特征。

方法

回顾性分析2020年6月26日济宁医学院附属医院急诊科收治的1例特发性多中心型Castleman病患者的临床资料，并复习相关文献。

结果

患者31岁，女性，因"发热1周"入院，伴乏力、咳嗽、腹胀等。体检多发淋巴结肿大；双下肺呼吸音低，叩诊浊音。胸部CT提示大量胸腔积液；给予抗感染治疗效果差。人类疱疹病毒8型(HHV-8)DNA定量检测在正常范围，人类免疫缺陷病毒(HIV)阴性。左侧颈部淋巴结活检病理学检查提示淋巴组织反应性增生，形态学呈Castleman病透明血管型改变，确诊为特发性多中心型Castleman病。

结论

及早完善HHV-8 DNA定量检测、免疫学相关指标、骨髓穿刺活检及淋巴结病理学检查等，有助于对Castleman病早期诊断和分型。

关键词: Castleman病, 特发性, 多中心, 诊断

Objective

To explore the diagnostic features of idiopathic multicentric Castleman disease.

Methods

The clinical data of a patient with idiopathic multicentric Castleman disease admitted to the emergency department of the Affiliated Hospital of Jining Medical University on June 26, 2020 was retrospectively analyzed, and relevant literatures were reviewed.

Results

The patient was a 31-year-old young female who was admitted to the hospital for " fever for 1 week" , accompanied by fatigue, cough, and abdominal distension. Physical examination showed multiple lymph node enlargement, low breath sounds in both lower lungs, and dull percussion note. Chest CT showed a large amount of pleural effusion, and anti-infective treatment was not effective.Human herpesvirus-8 (HHV-8) DNA quantitative detection was in the normal range, and human immunodeficiency virus (HIV) negative. The pathological examination of the left cervical lymph node biopsy showed reactive hyperplasia of lymphatic tissue, and the morphology showed the hyaline vascular change of Castleman′s disease. The patient was diagnosed with idiopathic polycentric Castleman′s disease.

Conclusion

Early improvement of HHV-8 DNA quantitative detection, immunological indicators, bone marrow biopsy and lymph node pathological examination are helpful for early diagnosis and typing of Castleman′s disease.

Key words: Castleman disease, Idiopathic, Multicenter, Diagnosis

[1]	Castleman B, Towne VW.Case records of the Massachusetts General Hospital：Case No.40231[J]．N Engl J Med，1954，250(23): 1001-1005.DOI: 10.1056/NEJM195406102502308.
[2]	Simpson D．Epidemiology of Castleman disease[J]．Hematol Oncol Clin North Am，2018，32(1): 1-10.DOI: 10.1016/j.hoc.2017.09.001.
[3]	Serpa Carmoma F, Cueva M, Serpa Carmoma F,，et al.Castleman′s disease：Laparoscopic resection of unicentric disease in the hepatic hilum：A case report[J]．Ann Med Surg (Lond)，2021(67): 102494.DOI: 10.1016/j.amsu.2021.102494.
[4]	Anwar GR, Mehr MT, Tahir D，et al.A case of Castleman disease：a diagnostic dilemma[J]．Cureus，2021，13(4): e14372.DOI: 10.7759/cureus.14372.
[5]	Wang HW, Pittaluga S, Jaffe ES.Multicentric Castleman disease：Where are we now? [J]．Semin Diagn Pathol，2016，33(5): 294-306.DOI: 10.1053/j.semdp.2016.05.006.
[6]	Fajgenbaum DC.Novel insights and therapeutic approaches in idiopathic multicentric Castleman disease[J]．Blood，2018，132(22): 2323-2330.DOI: 10.1182/blood-2018-05-848671.
[7]	Dispenzieri A, Fajgenbaum DC.Overview of Castleman disease[J]．Blood，2020，135(16): 1353-1364.DOI: 10.1182/blood.2019000931.
[8]	Fajgenbaum DC, Uldrick TS, Bagg A，et al.International，evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease[J]．Blood，2017，129(12): 1646-1657.DOI: 10.1182/blood-2016-10-746933.
[9]	Sakashita K, Murata K, Takamori M．TAFRO syndrome：current perspectives[J]．J Blood Med，2018(9): 15-23.DOI: 10.2147/JBM.S127822.
[10]	Tahseen S, Khanzada FM, Baloch AQ，et al.Extrapulmonary tuberculosis in Pakistan- A nation-wide multicenter retrospective study[J]．PLoS One，2020，15(4): e0232134.DOI: 10.1371/journal.pone.0232134.
[11]	中华医学会血液学分会淋巴细胞疾病学组，中国抗癌协会血液肿瘤专业委员会，中国Castleman病协作组．中国Castleman病诊断与治疗专家共识(2021年版)[J]．中华血液学杂志，2021(7): 529-534.DOI: 10.3760/cma.j.issn.0253-2727.2021.07.001.
[12]	Masaki Y, Nakajima A, Iwao H，et al.Japanese variant of multicentric castleman′s disease associated with serositis and thrombocytopenia-a report of two cases：is TAFRO syndrome (Castleman-Kojima disease) a distinct clinicopathological entity？[J]．J Clin Exp Hematop，2013，53(1): 79-85.DOI: 10.3960/jslrt.53.79.
[13]	Pierson SK, Stonestrom AJ, Shilling D，et al.Plasma proteomics identifies a ′chemokine storm' in idiopathic multicentric Castleman disease[J]．Am J Hematol，2018，93(7): 902-912.DOI: 10.1002/ajh.25123.
[14]	Fujimoto S, Sakai T, Kawabata H, et al. Is TAFRO syndrome a subtype of idiopathic multicentric Castleman disease？[J]．Am J Hematol，2019，94(9): 975-983.DOI: 10.1002/ajh.25554.
[15]	Nishimura Y, Hanayama Y, Fujii N，et al.Comparison of the clinical characteristics of TAFRO syndrome and idiopathic multicentric Castleman disease in general internal medicine：a 6-year retrospective study[J]．Intern Med J，2020，50(2): 184-191.DOI: 10.1111/imj.14404.
[16]	Yu L, Shi M, Cai Q，et al.A novel predictive model for idiopathic multicentric Castleman disease：the International Castleman Disease Consortium Study[J]．Oncologist，2020，25(11): 963-973.DOI: 10.1634/theoncologist.2019-0986.
[17]	van Rhee F, Voorhees P, Dispenzieri A, et al. International，evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease[J]．Blood，2018，132(20): 2115-2124.DOI: 10.1182/blood-2018-07-862334.

[1]	王亚红, 蔡胜, 葛志通, 杨筱, 李建初. 颅骨骨膜窦的超声表现一例[J/OL]. 中华医学超声杂志（电子版）, 2024, 21(11): 1089-1091.
[2]	唐金侨, 叶宇佳, 王港, 赵彬, 马艳宁. 医学影像学检查方法在颞下颌关节紊乱病中临床应用研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(06): 406-411.
[3]	赵林娟, 吕婕, 王文胜, 马德茂, 侯涛. 超声引导下染色剂标记切缘的梭柱型和圆柱型保乳区段切除术的效果研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 634-637.
[4]	屈翔宇, 张懿刚, 李浩令, 邱天, 谈燚. USP24及其共表达肿瘤代谢基因在肝细胞癌中的诊断和预后预测作用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 659-662.
[5]	熊鹰, 林敬莱, 白奇, 郭剑明, 王烁. 肾癌自动化病理诊断：AI离临床还有多远？[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 535-540.
[6]	中华医学会器官移植学分会. 肝移植术后缺血性胆道病变诊断与治疗中国实践指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 739-748.
[7]	郑大雯, 王健东. 胆囊癌辅助诊断研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 769-773.
[8]	王秋生. 胆道良性疾病诊疗策略[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 779-782.
[9]	袁雨涵, 杨盛力. 体液和组织蛋白质组学分析在肝癌早期分子诊断中的研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 883-888.
[10]	李浩, 陈棋帅, 费发珠, 张宁伟, 李元东, 王硕晨, 任宾. 慢性肝病肝纤维化无创诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 863-867.
[11]	谭瑞义. 小细胞骨肉瘤诊断及治疗研究现状与进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 781-784.
[12]	王子阳, 王宏宾, 刘晓旌. 血清标志物对甲胎蛋白阴性肝细胞癌诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 677-681.
[13]	陈慧, 邹祖鹏, 周田田, 张艺丹, 张海萍. 皮肤镜对头皮红斑性皮肤病辅助鉴别诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 692-698.
[14]	胡云鹤, 周玉焯, 付瑞瑛, 于凡, 李爱东. CHS-DRG付费制度下GB1分组住院费用影响因素分析与管理策略探讨[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 568-574.
[15]	奚培培, 周加军. 慢性肾脏病患者肌少症机制和诊治的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(05): 491-495.

阅读次数

全文

摘要

选择文件类型/文献管理软件名称

选择包含的内容

Diagnostic features of idiopathic multicentric Castleman disease and literature review

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

Diagnostic features of idiopathic multicentric Castleman disease and literature review