切换至 "中华医学电子期刊资源库"

中华诊断学电子杂志 ›› 2022, Vol. 10 ›› Issue (02) : 123 -127. doi: 10.3877/cma.j.issn.2095-655X.2022.02.011

临床研究

老年患者草绿色链球菌群感染的临床特征
任玥1, 孙占国2, 钱震雯3, 徐西为4, 山凤莲5, 蒋胜华6,()   
  1. 1. 272067 济宁医学院临床学院
    2. 272029 济宁医学院附属医院影像科
    3. 272029 济宁医学院附属医院检验科
    4. 272500 汶上县人民医院重症医学科
    5. 272029 济宁医学院附属医院感染科;272029 济宁医学院附属医院呼吸与危重症医学科
    6. 272029 济宁医学院附属医院呼吸与危重症医学科
  • 收稿日期:2021-01-28 出版日期:2022-04-26
  • 通信作者: 蒋胜华
  • 基金资助:
    山东省卫健委中医药项目(2019-0488); 济宁市重点研发计划项目(2020YXNS014)

Clinical characteristics of infection caused by viridans streptococci in elderly patients

Yue Ren1, Zhanguo Sun2, Zhenwen Qian3, Xiwei Xu4, Fenglian Shan5, Shenghua Jiang6,()   

  1. 1. College of Clinical Medicine, Jining Medical University, Jining 272067, China
    2. Department of Imaging, Affiliated Hospital of Jining Medical University, Jining 272029, China
    3. Department of Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining 272029, China
    4. Department of Critical Care Medicine, Wenshang People′s Hospital, Jining 272500, China
    5. Department of Infectious Disease, Affiliated Hospital of Jining Medical University, Jining 272029, China; Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Jining Medical University, Jining 272029, China
    6. Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Jining Medical University, Jining 272029, China
  • Received:2021-01-28 Published:2022-04-26
  • Corresponding author: Shenghua Jiang
引用本文:

任玥, 孙占国, 钱震雯, 徐西为, 山凤莲, 蒋胜华. 老年患者草绿色链球菌群感染的临床特征[J/OL]. 中华诊断学电子杂志, 2022, 10(02): 123-127.

Yue Ren, Zhanguo Sun, Zhenwen Qian, Xiwei Xu, Fenglian Shan, Shenghua Jiang. Clinical characteristics of infection caused by viridans streptococci in elderly patients[J/OL]. Chinese Journal of Diagnostics(Electronic Edition), 2022, 10(02): 123-127.

目的

探讨老年患者草绿色链球菌群感染的临床特征和病原菌特点。

方法

收集2016年6月至2020年12月济宁医学院附属医院细菌数据库中诊断为草绿色链球菌群感染的老年患者,年龄≥65岁,对其相关临床资料进行回顾性分析及总结。

结果

共收集患者75例,其中男性39例(52.00%),伴基础疾病者55例(73.33%)。30例(40.00%)患者以急性发热起病。分离菌群部位以正常无菌部位例数最多(58/75,77.33%)。具体致病菌分群:缓症链球菌11例(14.67%)、血链球菌14例(18.67%)、咽峡炎链球菌群50例(66.67%)。合并革兰氏阴性杆菌感染6例(8.00%),诱发中毒性休克综合征2例(2.67%)。药敏结果显示对红霉素、克林霉素、左氧氟沙星的耐药率分别为65.33%(49/75)、68.00%(51/75)、16.00%(12/75),对头孢曲松(6.67%,5/75)、头孢噻肟(4.00%,3/75)耐药率低。

结论

草绿色链球菌群作为常见的感染菌群,在老年人群中易发生机会感染。临床症状以发热常见,致病菌可累及多个系统,严重时可诱发中毒性休克综合征。

Objective

To explore the clinical characteristics and the pathogen characteristics of viridans streptococci infection in elderly patients.

Methods

A total of 75 elderly patients aged 65 years and above who were diagnosed with viridans streptococcal infection in the bacterial database of the Affiliated Hospital of Jining Medical University from June 2016 to December 2020 were sellected, and their related clinical data were summarized and retrospectively analyzed.

Results

75 elderly patients were collected, including 39 males (52.00%). There were 55 cases (73.33%) with basic diseases. Thirty cases (40.00%) conset by acute fever. The most common type of bacterial culture specimen was sterile body fluid. The classifications of bacterium were as follows: streptococcus mitis in 11 cases (14.67%), streptococcus sanguis in 14 cases (18.67%), streptococcus anginosus in 50 cases (66.67%). Six cases (8.00%) were infected combining with gram-negative bacilli, 2 cases (2.67%) underwent toxic shock syndrome. The drug resistance rates of erythromycin, clindamycin and levofloxacin were 65.33% (49/75), 68.00% (51/75) and 16.00% (12/75) and low resistance rate to ceftriaxone (6.67%, 5/75) and cefotaxime (4.00%, 3/75).

Conclusions

Streptococcus virifolia is a common infection group, which is prone to opportunistic infection in the elderly population. Fever is the most common clinical symptom, and pathogenic bacteria may involve multiple systems, and toxic shock syndrome may be induced in severe cases.

表1 草绿色链球菌群感染老年患者感染部位
表2 草绿色链球菌群感染老年患者分离菌群部位
[1]
Ruoff KL, Fishman JA, Calderwood SB, et al. Distribution and incidence of viridans streptococcal species in routine clinical specimens[J].Am J Clin Pathol198380(6):854-858.DOI:10.1093/ajcp/80.6.854.
[2]
Fazili T, Riddell S, Kiska D, et al.Streptococcus anginosus Group Bacterial Infections[J] .Am J Med Sci2017354(3):257-261.DOI:10.1016/j.amjms.2017.05.011.
[3]
Maeda Y, Goldsmith CE, Coulter WA,et al.The viridans group streptococci[J] .Rev Med Microbio201021(4):69-79.DOI:10.1097/MRM.0b013e32833c68fa.
[4]
董畅,张中和.草绿色链球菌肺部感染的研究进展[J].中华结核和呼吸杂志201538(4):301-304.DOI:10.3760/cma.j.issn.1001-0939.2015.04.015.
[5]
范晔,徐志飞.呼吸道疾病中的性别差异[J].国际呼吸杂志200727(15):1157-1160.DOI:10.3760/cma.j.issn.1673-436X.2007.15.011.
[6]
王凤芹,衣红霞.老年呼吸系统慢性疾病患者652例年龄、性别、文化程度、居住环境等相关因素分析[J].中国临床康复20048(12):2214.DOI:10.3321/j.issn:1673-8225.2004.12.096.
[7]
Noguchi S, Yatera K, Kawanami T,et al.The clinical features of respiratory infections caused by the Streptococcus anginosus group[J].BMC Pulm Med2015(15):133.DOI:10.1186/s12890-015-0128-6.
[8]
叶恒志,成凤韬.老年患者泌尿系感染的临床特点和危险因素分析[J/CD].中华实验和临床感染病杂志(电子版)20137(3):108-110.DOI:10.3877/cma.j.issn.1674-1358.2013.03.028.
[9]
黄炳坤,范世珍,林松青,等.老年女性泌尿系感染病原学分析[J].现代中西医结合杂志201322(10):1108-1110.DOI:10.3969/j.issn.1008-8849.2013.10.041.
[10]
Siegman-Igra Y, Azmon Y, Schwartz D.Milleri group streptococcus-a stepchild in the viridans family[J].Eur J Clin Microbiol Infect Dis201231(9):2453-2459.DOI:10.1007/s10096-012-1589-7.Epub 2012 Mar 6.
[11]
李岷,山凤莲,钱震雯,等.米勒链球菌群感染患者159例临床特征分析[J].中华全科医师杂志202019(7):631-634.DOI:10.3760/cma.j.cn114798-20200327-00375.
[12]
Jiang SH, Li M, Fu T,et al.Clinical characteristics of infections caused by streptococcus anginosus group[J].SCI REP-UK202010(1):9032.DOI:10.1038/s41598-020-65977-z.
[13]
李萍.老年口腔健康状况调查及相关因素分析[J].中国老年学杂志201131(2):341-342.DOI:10.3969/j.issn.1005-9202.2011.02.079.
[14]
闫晨华,徐婷,郑晓云,等.中国血液病患者中性粒细胞缺乏伴发热的多中心、前瞻性流行病学研究[J].中华血液学杂志201637(3):177-182.DOI:10.3760/cma.j.issn.0253-2727.2016.03.001.
[15]
Shenep JL.Viridans-group streptococcal infections in immunocompromised hosts[J].Int J Antimicrob Agents200014(2):129-135.DOI:10.1016/s0924-8579(99)00172-7.
[16]
Chiang AD, Sinaii N, Palmore TN.Risk factors for viridans group streptococcal bacteremia in neutropenic and non-neutropenic patients:a single center case-case-control study[J].Open Forum Infect Dis20175(1):ofx260.DOI:10.1093/ofid/ofx260.eCollection 2018 Jan.
[17]
Wisplinghoff H, Reinert RR, Cornely O,et al.Molecular relationships and antimicrobial susceptibilities of viridans group streptococci isolated from blood of neutropenic cancer patients[J].J Clin Microbiol199937(6):1876-1880.DOI:10.1128/JCM.37.6.1876-1880.1999.
[18]
Krishna V, Sankaranarayan S, Sivaraman RP,et al.Streptococcal toxic shock syndrome[J].Indian J Pediatr201481(9):946-948.DOI:10.1007/s12098-013-1272-8.
[19]
胡付品,郭燕,朱德妹,等.2017年CHINET中国细菌耐药性监测[J].中国感染与化疗杂志201818(3):241-251.DOI:10.16718/j.1009-7708.2018.03.001.
[20]
林志航,明德松,郭如意.213株草绿色链球菌的分布和耐药性分析[J].中国抗生素杂志201742(11):989-992.DOI:10.13461/j.cnki.cja.006116.
[21]
马维秀,崔金霞,范忠敏,等.204例社区获得性肺炎患者感染草绿色链球菌种类及其耐药性分析[J].中国病原生物学杂志201813(10):1142-1144.DOI:10.13350/j.cjpb.181018.
[1] 王亚红, 蔡胜, 葛志通, 杨筱, 李建初. 颅骨骨膜窦的超声表现一例[J/OL]. 中华医学超声杂志(电子版), 2024, 21(11): 1089-1091.
[2] 屈翔宇, 张懿刚, 李浩令, 邱天, 谈燚. USP24及其共表达肿瘤代谢基因在肝细胞癌中的诊断和预后预测作用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 659-662.
[3] 赵林娟, 吕婕, 王文胜, 马德茂, 侯涛. 超声引导下染色剂标记切缘的梭柱型和圆柱型保乳区段切除术的效果研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 634-637.
[4] 熊鹰, 林敬莱, 白奇, 郭剑明, 王烁. 肾癌自动化病理诊断:AI离临床还有多远?[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 535-540.
[5] 宋俊锋, 张珍珍. 单侧初发性腹股沟斜疝老年患者经腹腹膜前疝修补术中残余疝囊腹直肌下缘固定效果评估[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 670-674.
[6] 张晋伟, 董永红, 王家璇. 基于GBD2021 数据库对中国与全球老年人疝疾病负担和健康不平等的分析比较[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 708-716.
[7] 袁雨涵, 杨盛力. 体液和组织蛋白质组学分析在肝癌早期分子诊断中的研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 883-888.
[8] 中华医学会器官移植学分会. 肝移植术后缺血性胆道病变诊断与治疗中国实践指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 739-748.
[9] 郑大雯, 王健东. 胆囊癌辅助诊断研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 769-773.
[10] 王贝贝, 崔振义, 王静, 王晗妍, 吕红芝, 李秀婷. 老年股骨粗隆间骨折患者术后贫血预测模型的构建与验证[J/OL]. 中华老年骨科与康复电子杂志, 2024, 10(06): 355-362.
[11] 李浩, 陈棋帅, 费发珠, 张宁伟, 李元东, 王硕晨, 任宾. 慢性肝病肝纤维化无创诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 863-867.
[12] 谭瑞义. 小细胞骨肉瘤诊断及治疗研究现状与进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 781-784.
[13] 王子阳, 王宏宾, 刘晓旌. 血清标志物对甲胎蛋白阴性肝细胞癌诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 677-681.
[14] 陈慧, 邹祖鹏, 周田田, 张艺丹, 张海萍. 皮肤镜对头皮红斑性皮肤病辅助鉴别诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 692-698.
[15] 胡云鹤, 周玉焯, 付瑞瑛, 于凡, 李爱东. CHS-DRG付费制度下GB1分组住院费用影响因素分析与管理策略探讨[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 568-574.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?