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中华诊断学电子杂志 ›› 2022, Vol. 10 ›› Issue (03) : 158 -162. doi: 10.3877/cma.j.issn.2095-655X.2022.03.003

内分泌代谢性疾病诊治

神经酰胺与糖尿病及其并发症关系研究进展
冉启玉1, 杜鹏宇1, 孔蕾1, 孙冰2,()   
  1. 1. 272013 济宁医学院临床医学院
    2. 272067 济宁医学院中西医结合学院
  • 收稿日期:2021-11-29 出版日期:2022-08-26
  • 通信作者: 孙冰
  • 基金资助:
    山东省自然科学基金(ZR2016HM65)

Research progress on the relationship between ceramide and diabetes mellitus and its complications

Qiyu Ran1, Pengyu Du1, Lei Kong1, Bing Sun2,()   

  1. 1. College of Clinical Medicine, Jining Medical University, Jining 272013, China
    2. College of Integrated Chinese and Western Medicine, Jining Medical University, Jining 272067, China
  • Received:2021-11-29 Published:2022-08-26
  • Corresponding author: Bing Sun
引用本文:

冉启玉, 杜鹏宇, 孔蕾, 孙冰. 神经酰胺与糖尿病及其并发症关系研究进展[J]. 中华诊断学电子杂志, 2022, 10(03): 158-162.

Qiyu Ran, Pengyu Du, Lei Kong, Bing Sun. Research progress on the relationship between ceramide and diabetes mellitus and its complications[J]. Chinese Journal of Diagnostics(Electronic Edition), 2022, 10(03): 158-162.

在全球,每11位成年人中就有1例糖尿病患者,糖尿病对人体的威胁主要是其严重的有时甚至危及生命的并发症。神经酰胺是一种鞘脂类物质,在信号转导途径调控中起着关键作用,其主要由从头合成途径、鞘磷脂水解/降解途径、回收/补救途径3种途径合成。近年的研究表明,神经酰胺可通过诱导β细胞凋亡、胰岛素抵抗和抑制胰岛素基因表达等多种机制参与糖尿病的发生及进展。特定的神经酰胺种类或神经酰胺比例可能作为糖尿病风险的生物标志物,理解神经酰胺在糖尿病及其并发症中的作用对指导治疗有重要意义。笔者详细介绍了神经酰胺与糖尿病及其并发症的进展关系及机制,特别强调了神经酰胺与糖尿病视网膜病变、糖尿病肾病、糖尿病心血管疾病和糖尿病神经病变的进展机制,着重关注并介绍了一些潜在的、新兴的治疗策略。

Globally, 1 in 11 adults has diabetes, and the threat of diabetes to the human body is mainly its serious, sometimes life-threatening complications. Ceramide is a sphingolipid substance that plays a key role in the regulation of signal transduction pathways, which is mainly synthesized by three pathways: de novo synthesis pathway, sphingomyelin hydrolysis/degradation pathway and recovery/remediation pathway. Ceramide has been linked to the development of diabetes by inducing β cell apoptosis, insulin resistance, and inhibiting insulin gene expression. Some species or ceramide proportions of ceramide may serve as biomarkers of diabetes risk, and understanding the role of ceramides in diabetes and its complications is critical for treatment planning.This review discusses the relationship and mechanism of ceramides in the progression of diabetes and its complications, with a focus on the mechanisms of correlation between ceramides and diabetic retinopathy, diabetic nephropathy, diabetic cardiovascular disease, and diabetic neuropathy, as well as some potential and emerging treatment strategies.

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