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中华诊断学电子杂志 ›› 2023, Vol. 11 ›› Issue (01) : 1 -4. doi: 10.3877/cma.j.issn.2095-655X.2023.01.001

心血管疾病诊治

囊泡在冠状动脉钙化过程中的作用
神童1, 申程2, 甘立军2,()   
  1. 1. 272013 济宁医学院临床医学院
    2. 272029 济宁医学院附属医院心内科
  • 收稿日期:2022-05-11 出版日期:2023-02-26
  • 通信作者: 甘立军
  • 基金资助:
    国家自然科学基金(81400860,82000269); 山东省自然科学基金(ZR2019MH087); 济宁市重点研发计划(2020JKNS006); 济宁医学院附属医院面上项目(2020JKNS006)

The role of vesicles in the process of coronary artery calcification

Tong Shen1, Cheng Shen2, Lijun Gan2,()   

  1. 1. College of Clinical Medicine, Jining Medical University, Jining 272013, China
    2. Department of Cardiology, the Affiliated Hospital of Jining Medical University, Jining 272029, China
  • Received:2022-05-11 Published:2023-02-26
  • Corresponding author: Lijun Gan
引用本文:

神童, 申程, 甘立军. 囊泡在冠状动脉钙化过程中的作用[J]. 中华诊断学电子杂志, 2023, 11(01): 1-4.

Tong Shen, Cheng Shen, Lijun Gan. The role of vesicles in the process of coronary artery calcification[J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(01): 1-4.

冠状动脉钙化是导致冠心病发生的重要因素,此过程即为冠状动脉内的矿物质在血管管壁的异常沉积,其机制较为复杂,与钙磷代谢、细胞调节等相关。囊泡是由磷脂双分子层构成的封闭结构,由细胞产生,具有转运生物学物质、调节细胞功能等作用,不同来源的囊泡其功能也有所不同。冠状动脉钙化的过程有囊泡参与其中,在此过程中囊泡亦起到了调节、运输等作用,囊泡或许可作为诊断、预测冠状动脉钙化的新标记物,并对冠状动脉钙化的治疗发挥作用。笔者主要对囊泡在冠状动脉钙化过程中的作用进行综述。

Coronary artery calcification is an important factor leading to coronary heart disease. This process is the abnormal deposition of minerals in the coronary artery on the vessel wall. Its mechanisms are complex, which are related to calcium and phosphorus metabolism, cell regulation and so on. Vesicles are closed structures composed of phospholipid bilayer, which are produced by cells. They have functions such as transporting biological substances and regulating cell functions, and the functions of vesicles from different sources are also different. The process of coronary artery calcification involves vesicles, which also play a role in regulation and transportation. Vesicles may be used as a new marker to diagnose and predict coronary artery calcification, as well as to aid in its management. The author mainly reviews the function of vesicles in the process of coronary artery calcification.

图1 囊泡参与冠脉钙化的机制示意图注:心肌细胞摄取脂肪细胞分泌的囊泡后产生活性氧(ROS)自由基,ROS诱导内皮细胞功能障碍,功能障碍的内皮细胞破坏血管的结构及功能,导致冠脉钙化;血清钙、磷水平升高诱导囊泡表面磷脂酰丝氨酸暴露,继而转移到囊泡外膜并结合S100A9和膜联蛋白,形成磷脂酰丝氨酸-膜联蛋白-5-S100A9复合物,促进羟基磷灰石成核,参与钙化形成
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