切换至 "中华医学电子期刊资源库"

中华诊断学电子杂志 ›› 2023, Vol. 11 ›› Issue (01) : 1 -4. doi: 10.3877/cma.j.issn.2095-655X.2023.01.001

心血管疾病诊治

囊泡在冠状动脉钙化过程中的作用
神童1, 申程2, 甘立军2,()   
  1. 1. 272013 济宁医学院临床医学院
    2. 272029 济宁医学院附属医院心内科
  • 收稿日期:2022-05-11 出版日期:2023-02-26
  • 通信作者: 甘立军
  • 基金资助:
    国家自然科学基金(81400860,82000269); 山东省自然科学基金(ZR2019MH087); 济宁市重点研发计划(2020JKNS006); 济宁医学院附属医院面上项目(2020JKNS006)

The role of vesicles in the process of coronary artery calcification

Tong Shen1, Cheng Shen2, Lijun Gan2,()   

  1. 1. College of Clinical Medicine, Jining Medical University, Jining 272013, China
    2. Department of Cardiology, the Affiliated Hospital of Jining Medical University, Jining 272029, China
  • Received:2022-05-11 Published:2023-02-26
  • Corresponding author: Lijun Gan
引用本文:

神童, 申程, 甘立军. 囊泡在冠状动脉钙化过程中的作用[J/OL]. 中华诊断学电子杂志, 2023, 11(01): 1-4.

Tong Shen, Cheng Shen, Lijun Gan. The role of vesicles in the process of coronary artery calcification[J/OL]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(01): 1-4.

冠状动脉钙化是导致冠心病发生的重要因素,此过程即为冠状动脉内的矿物质在血管管壁的异常沉积,其机制较为复杂,与钙磷代谢、细胞调节等相关。囊泡是由磷脂双分子层构成的封闭结构,由细胞产生,具有转运生物学物质、调节细胞功能等作用,不同来源的囊泡其功能也有所不同。冠状动脉钙化的过程有囊泡参与其中,在此过程中囊泡亦起到了调节、运输等作用,囊泡或许可作为诊断、预测冠状动脉钙化的新标记物,并对冠状动脉钙化的治疗发挥作用。笔者主要对囊泡在冠状动脉钙化过程中的作用进行综述。

Coronary artery calcification is an important factor leading to coronary heart disease. This process is the abnormal deposition of minerals in the coronary artery on the vessel wall. Its mechanisms are complex, which are related to calcium and phosphorus metabolism, cell regulation and so on. Vesicles are closed structures composed of phospholipid bilayer, which are produced by cells. They have functions such as transporting biological substances and regulating cell functions, and the functions of vesicles from different sources are also different. The process of coronary artery calcification involves vesicles, which also play a role in regulation and transportation. Vesicles may be used as a new marker to diagnose and predict coronary artery calcification, as well as to aid in its management. The author mainly reviews the function of vesicles in the process of coronary artery calcification.

图1 囊泡参与冠脉钙化的机制示意图注:心肌细胞摄取脂肪细胞分泌的囊泡后产生活性氧(ROS)自由基,ROS诱导内皮细胞功能障碍,功能障碍的内皮细胞破坏血管的结构及功能,导致冠脉钙化;血清钙、磷水平升高诱导囊泡表面磷脂酰丝氨酸暴露,继而转移到囊泡外膜并结合S100A9和膜联蛋白,形成磷脂酰丝氨酸-膜联蛋白-5-S100A9复合物,促进羟基磷灰石成核,参与钙化形成
[1]
Johnson RC, Leopold JA, Loscalzo J.Vascular calcification:pathobiological mechanisms and clinical implications[J].Circ Res200699(10):1044-1059.DOI:10.1161/01.RES.0000249379.55535.21.
[2]
Yuan C, Ni L, Zhang C,et al.Vascular calcification:new insights into endothelial cells[J].Microvasc Res2021(134):104105.DOI:10.1016/j.mvr.2020.104105.
[3]
Durham AL, Speer MY, Scatena M,et al.Role of smooth muscle cells in vascular calcification:implications in atherosclerosis and arterial stiffness[J].Cardiovasc Res2018114(4):590-600.DOI:10.1093/cvr/cvy010.
[4]
王琎,陈建英.细胞外囊泡研究新进展[J].中国组织工程研究201721(4):621-626.DOI:10.3969/j.issn.2095-4344.2017.04.022.
[5]
Doyle LM, Wang MZ. Overview of extracellular vesicles, their origin,composition,purpose,and methods for exosome isolation and analysis[J].Cells20198(7):727.DOI:10.3390/cells8070727.
[6]
Li S, Zhan JK, Wang YJ,et al.Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells[J].Cell Biosci2019(9):1.DOI:10.1186/s13578-018-0263-x.
[7]
Lin X, Zhu T, Xu F,et al.Plasma exosomes derived from patients with end-stage renal disease and renal transplant recipients have different effects on vascular calcification[J].Front Cell Dev Biol2020(8):618228.DOI:10.3389/fcell.2020.618228.
[8]
Freise C, Querfeld U, Ludwig A,et al.Uraemic extracellular vesicles augment osteogenic transdifferentiation of vascular smooth muscle cells via enhanced AKT signalling and PiT-1 expression[J].J Cell Mol Med202125(12):5602-5614.DOI:10.1111/jcmm.16572.
[9]
Mas-Bargues C, Borrás C, Alique M.The contribution of extracellular vesicles from senescent endothelial and vascular smooth muscle cells to vascular calcification[J].Front Cardiovasc Med2022(9):854726.DOI:10.3389/fcvm.2022.854726.
[10]
Wu M, Rementer C, Giachelli CM.Vascular calcification:an update on mechanisms and challenges in treatment[J].Calcif Tissue Int201393(4):365-373.DOI:10.1007/s00223-013-9712-z.
[11]
Chen NX, O'Neill KD, Moe SM.Matrix vesicles induce calcification of recipient vascular smooth muscle cells through multiple signaling pathways[J].Kidney Int201893(2):343-354.DOI:10.1016/j.kint.2017.07.019.
[12]
Furmanik M, Chatrou M, van Gorp R,et al.Reactive oxygen-forming Nox 5 links vascular smooth muscle cell phenotypic switching and extracellular vesicle-mediated vascular calcification[J].Circ Res2020127(7):911-927.DOI:10.1161/CIRCRESAHA.119.316159.
[13]
Crewe C, Funcke JB, Li S,et al.Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes[J].Cell Metab202133(9):1853-1868.e11.DOI:10.1016/j.cmet.2021.08.002.
[14]
Liu L, Ni YQ, Zhan JK, et al. The role of SGLT2 inhibitors in vascular aging[J].Aging Dis202112(5):1323-1336.DOI:10.14336/AD.2020.1229.
[15]
Chen YT, Yuan HX, Ou ZJ,et al.Microparticles (exosomes) and atherosclerosis[J].Curr Atheroscler Rep202022(6):23.DOI:10.1007/s11883-020-00841-z.
[16]
Zhang YX, Tang RN, Wang LT, et al. Role of crosstalk between endothelial cells and smooth muscle cells in vascular calcification in chronic kidney disease[J].Cell Prolif202154(3):e12980.DOI:10.1111/cpr.12980.
[17]
Xiong Y, Chen L, Yan C,et al.Circulating exosomal miR-20b-5p inhibition restores wnt9b signaling and reverses diabetes-associated impaired wound healing[J].Small202016(3):e1904044.DOI:10.1002/smll.201904044.
[18]
Rackov G, Garcia-Romero N, Esteban-Rubio S,et al.Vesicle-mediated control of cell function:the role of extracellular matrix and microenvironment[J].Front Physiol2018(9):651.DOI:10.3389/fphys.2018.00651.
[19]
Kapustin AN, Chatrou ML, Drozdov I,et al.Vascular smooth muscle cell calcification is mediated by regulated exosome secretion[J].Circ Res2015116(8):1312-1323.DOI:10.1161/CIRCRESAHA.116.305012.
[20]
苏冠月,汪小力,裴童,等.外泌体调控血管钙化的研究进展[J].中国科学(生命科学)202050(9):973-982.DOI:10.1360/SSV-2020-0108.
[21]
Qin Z, Liao R, Xiong Y,et al.A narrative review of exosomes in vascular calcification[J].Ann Transl Med20219(7):579.DOI:10.21037/atm-20-7355.
[22]
姚天成,王伟杰,杨莹莹,等. 7,8-二羟基黄酮对自发性高血压大鼠血管平滑肌细胞表型转化的影响[J/CD].中华诊断学电子杂志20186(3):202-206. DOI:10.3877/cma.j.issn.2095-655X.2018.03.013.
[23]
Bhat OM, Yuan X, Camus S,et al.Abnormal lysosomal positioning and small extracellular vesicle secretion in arterial stiffening and calcification of mice lacking mucolipin 1 gene[J].Int J Mol Sci202021(5):1713.DOI:10.3390/ijms21051713.
[24]
Connolly KD, Rees DA, James PE.Role of adipocyte-derived extracellular vesicles in vascular inflammation[J].Free Radic Biol Med2021(172):58-64.DOI:10.1016/j.freeradbiomed.2021.04.031.
[25]
Demer LL, Tintut Y.Inflammatory,metabolic,and genetic mechanisms of vascular calcification[J].Arterioscler Thromb Vasc Biol201434(4):715-723.DOI:10.1161/ATVBAHA.113.302070.
[26]
Wang S, Dong X, Gao J,et al.Targeting inflammatory vasculature by extracellular vesicles[J].AAPS J201820(2):37.DOI:10.1208/s12248-018-0200-2.
[27]
Harrell CR, Jovicic N, Djonov V,et al.Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases[J].Cells20198(12):1605.DOI:10.3390/cells8121605.
[28]
Dai XY, Zhao MM, Cai Y,et al.Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release[J].Kidney Int201383(6):1042-1051.DOI:10.1038/ki.2012.482.
[29]
Yang X, Song X, Li Z,et al.Crosstalk between extracellular vesicles and autophagy in cardiovascular pathophysiology[J].Pharmacol Res2021(172):105628.DOI:10.1016/j.phrs.2021.105628.
[30]
Chen R, Xu Y, Zhong W,et al.Activation of CD137 signaling enhances vascular calcification through c-jun n-terminal kinase-dependent disruption of autophagic flux[J].Mediators Inflamm2018(2018):8407137.DOI:10.1155/2018/8407137.
[31]
Nguyen D, Chilian WM, Zain SM,et al.MicroRNA regulation of vascular smooth muscle cells and its significance in cardiovascular diseases[J].Can J Physiol Pharmacol202199(9):827-838.DOI:10.1139/cjpp-2020-0581.
[32]
Li X, He X, Wang J,et al.The regulation of exosome-derived miRNA on heterogeneity of macrophages in atherosclerotic plaques[J].Front Immunol2020(11):2175.DOI:10.3389/fimmu.2020.02175.
[33]
张帆,张聪聪,程乃萱,等.冠心病患者血清外泌体微小核糖核酸-141-3p对内皮细胞损伤的影响研究[J].心肺血管病杂志202140(3):223-228.DOI:10.3969/j.issn.1007-5062.2021.03.002.
[34]
Bakhshian Nik A, Hutcheson JD, Aikawa E.Extracellular vesicles as mediators of cardiovascular calcification[J].Front Cardiovasc Med2017(4):78.DOI:10.3389/fcvm.2017.00078.
[35]
Guo Y, Bao S, Guo W,et al.Bone marrow mesenchymal stem cell-derived exosomes alleviate high phosphorus-induced vascular smooth muscle cells calcification by modifying microRNA profiles[J].Funct Integr Genomics201919(4):633-643.DOI:10.1007/s10142-019-00669-0.
[36]
Xu F, Zhong JY, Lin X,et al.Melatonin alleviates vascular calcification and ageing through exosomal miR-204/miR-211 cluster in a paracrine manner[J].J Pineal Res202068(3):e12631.DOI:10.1111/jpi.12631.
[1] 蚁淳, 袁冬生, 熊学军. 系统免疫炎症指数与骨密度降低和骨质疏松的关联[J/OL]. 中华关节外科杂志(电子版), 2024, 18(05): 609-617.
[2] 王振宇, 张洪美, 荆琳, 何名江, 闫奇. 膝骨关节炎相关炎症因子与血浆代谢物间的因果关系及中介效应[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 467-473.
[3] 张洁, 罗小霞, 余鸿. 系统性免疫炎症指数对急性胰腺炎患者并发器官功能损伤的预测价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 68-71.
[4] 唐梅, 周丽, 牛岑月, 周小童, 王倩. ICG荧光导航的腹腔镜肝切除术临床意义[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 655-658.
[5] 付成旺, 杨大刚, 王榕, 李福堂. 营养与炎症指标在可切除胰腺癌中的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 704-708.
[6] 杜贵伟, 陆勇, 成博, 贺薏, 梁爽. 钬激光碎石术术后联合坦索罗辛治疗对输尿管结石患者的影响分析[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 491-496.
[7] 高娟, 徐建庆, 闫芳, 丁盛华, 刘霞. Rutkow、TAPP、TEP 手术治疗单侧腹股沟疝患者的临床疗效及对血清炎症因子水平的影响[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 675-680.
[8] 李智, 冯芸. NF-κB 与MAPK 信号通路及其潜在治疗靶点在急性呼吸窘迫综合征中的研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 840-843.
[9] 孙璐, 蒋亚玲, 陈凌君. 布托啡诺对脑缺血再灌注损伤大鼠神经炎症和JAK2/STAT3信号通路的影响[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 344-350.
[10] 王国强, 张纲, 唐建坡, 张玉国, 杨永江. LINC00839 调节miR-17-5p/WEE1 轴对结直肠癌细胞增殖、凋亡和迁移的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 491-499.
[11] 史清泉, 苗彬, 王烁, 陶琳, 沈晨. miR-181a-5p 靶向ATG5 抑制雨蛙素诱导的大鼠胰腺腺泡细胞AR42J自噬的机制研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 524-530.
[12] 陈利, 杨长青, 朱风尚. 重视炎症性肠病和代谢相关脂肪性肝病间的串话机制研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 385-389.
[13] 王湛, 李文坤, 杨奕, 徐芳, 周敏思, 苏珈仪, 王亚丹, 吴静. 炎症指标在早发性结直肠肿瘤中的应用[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 802-810.
[14] 欧春影, 李晓宾, 郭靖, 朱亮, 许可, 王梦, 安晓雷. 丁苯酞对血管性认知障碍大鼠炎症因子的影响及对认知障碍的改善作用[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 483-487.
[15] 牟磊, 徐东成, 韩鑫, 徐长江, 韩坤锜, 薛叶潇, 牟媛, 秦文玲, 刘相静, 陈哲, 高楠. 五虫通络胶囊防治椎动脉开口支架术后再狭窄发生的效果[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 467-472.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?