探讨特鲁索综合征的临床诊断特征。

回顾性分析2021年5月4日复旦大学附属中山医院青浦分院神经内科收治的1例特鲁索综合征患者的临床资料，结合文献，总结其临床诊断特征。

患者女性，80岁，因言语障碍2 d入院；既往有肺部恶性肿瘤病史2年，靶向药物治疗中；入院查体可见其言语不能。凝血常规提示D-二聚体水平显著升高，头颅MRI提示双侧小脑、双侧大脑半球散在急性缺血梗死灶。肺部CT提示右肺上叶占位，考虑特鲁索综合征。入院后予以抗凝、活血治疗，治疗3 d后，因皮肤大量瘀斑、牙龈出血，放弃抗凝治疗，后患者病情进展出现精神行为异常、进食障碍，家属拒绝后续治疗，签字出院。

对于颅内多动脉供血区域梗死的患者，若其同时合并有D-二聚体水平明显升高，需要考虑特鲁索综合征。

To explore Trousseau′s syndrome′s clinical diagnostic features.

The clinical data of a patient with Trousseau′s syndrome admitted to the Neurology Department of Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University on May 4, 2021 were retrospectively analyzed, and the clinical characteristics were explored based on the literatures.

The 80-year-old female patient was admitted to the hospital for 2 days due to a speech disorder. She was undergoing targeted drug therapy and had suffered from pulmonary malignancy for the past 2 years. Upon admittance, a physical examination revealed that she was aphasic. Her blood was highly coagulable, as evidenced by the significant increase in the value of D-dimer after the coagulation function test. Her bilateral cerebellum and cerebral hemisphere both displayed dispersed acute ischemic focus, according to a brain MRI. The right upper lung had a tumor, according to the lung CT. We had reasons to believing Trousseau′s syndrome was the cause. Due to her dermatorrhagia and bleeding gums, we had forced to stop the anticoagulant therapy after the treatment that combined anticoagulation and stimulating the circulation. The patient′s family refused further therapy and consented for discharge as soon as the patient begun to have hazy memories and an eating disorder.

Patients with cerebral infarction involving multiple vascular territories and significantly elevated D-dimer at the same time should be evaluated for Trousseau′s syndrome.