切换至 "中华医学电子期刊资源库"

中华诊断学电子杂志 ›› 2023, Vol. 11 ›› Issue (02) : 125 -127. doi: 10.3877/cma.j.issn.2095-655X.2023.02.011

内分泌代谢性疾病诊治

硒联合不同药物治疗桥本甲状腺炎的研究进展
王正宇1, 孙琳2,()   
  1. 1. 272013 济宁医学院临床医学院
    2. 272002 济宁市第一人民医院内分泌科
  • 收稿日期:2022-01-29 出版日期:2023-05-04
  • 通信作者: 孙琳

Research progress of selenium combined with different drugs in the treatment of Hashimoto thyroiditis

Zhengyu Wang1, Lin Sun2,()   

  1. 1. College of Clinical Medicine, Jining Medical University, Jining 272013, China
    2. Department of Endocrinology, the First People′s Hospital of Jining, Jining 272002, China
  • Received:2022-01-29 Published:2023-05-04
  • Corresponding author: Lin Sun
引用本文:

王正宇, 孙琳. 硒联合不同药物治疗桥本甲状腺炎的研究进展[J]. 中华诊断学电子杂志, 2023, 11(02): 125-127.

Zhengyu Wang, Lin Sun. Research progress of selenium combined with different drugs in the treatment of Hashimoto thyroiditis[J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(02): 125-127.

硒是对人体健康必不可少的微量矿物质,在人体中以硒蛋白的形式存在,参与抗氧化、抗炎过程及活性甲状腺激素的产生。体内硒蛋白含量不足可能导致氧化应激失衡、下调机体免疫功能,从而参与桥本甲状腺炎(HT)疾病的发生发展,而补充硒可能有助于HT的预防和治疗。目前国内外已经开始重视硒缺乏与HT的相关性研究,对其预防、治疗也在进一步地探索。笔者主要对硒联合其他药物治疗HT的研究进展进行综述。

Selenium is a trace mineral that is essential for maintaining human health. Selenium is present in the body as selenoproteins, which are involved in antioxidant, anti-inflammatory process, and the production of active thyroid hormone synthesis. The imbalance of oxidative stress and the downregulation of immune function that results from a lack of selenoproteins in the body may contribute to the occurrence and progression of Hashimoto thyroiditis (HT). Selenium supplementation may aid in the prevention and treatment of HT. The study of the relationship between selenium insufficiency and HT, as well as the prevention and treatment of selenium deficiency, has begun to attract domestic and international attention. This article discusses recent developments in selenium and its use in combination with other drugs for the prevention and treatment of HT.

[1]
Ragusa FFallahi PElia G,et al.Hashimotos′ thyroiditis:epidemiology,pathogenesis,clinic and therapy[J].Best Pract Res Clin Endocrinol Metab201933(6):101367.DOI:10.1016/j.beem.2019.101367.
[2]
黄园园,刘亚楠,于世鹏. CD4+T淋巴细胞相关细胞因子与桥本氏甲状腺炎发病机制的研究进展[J/CD].中华诊断学电子杂志20197(3):214-216. DOI:10.3877/cma.j.issn.2095-655X.2019.03.016.
[3]
张国玉,万会娜,郭盼盼,等.桥本甲状腺炎发病因素及发病机制研究进展[J].新乡医学院学报202037(10):984-989,995.DOI:10.7683/xxyxyxb.2020.10.019.
[4]
Ralli M, Angeletti D, Fiore M, et al. Hashimoto′s thyroiditis:an update on pathogenicmechanisms,diagnostic protocols,therapeutic strategies,and potential malignant transformation[J].Autoimmun Rev202019(10):102649.DOI:10.1016/j.autrev.2020.102649.
[5]
Avery JCHoffmann PR.Selenium,selenoproteins,and immunity[J].Nutrients201810(9):1203.DOI:10.3390/nu10091203.
[6]
Weetman AP. An update on the pathogenesis of Hashimoto′s thyroiditis[J].J Endocrinol Invest202144(5):883-890.DOI:10.1007/s40618-020-01477-1.
[7]
Wu QRayman MPLv H,et al.Low population selenium status is associated with increased prevalence of thyroid disease[J].J Clin Endocrinol Metab2015100(11):4037-4047.DOI:10.1210/jc.2015-2222.
[8]
Hu SRayman MP.Multiple nutritional factors and the risk of Hashimoto's thyroiditis[J].Thyroid201727(5):597-610.DOI:10.1089/thy.2016.0635.
[9]
Rostami RNourooz-Zadeh SMohammadi A,et al.Serum selenium status and its interrelationship with serum biomarkers of thyroid function and antioxidant defense in Hashimoto's thyroiditis[J].Antioxidants (Basel)20209(11):1070.DOI:10.3390/antiox9111070.
[10]
Ventura MMelo MCarrilho F.Selenium and thyroid disease:from pathophysiology to treatment[J].Int J Endocrinol2017(2017):1297658.DOI:10.1155/2017/1297658.
[11]
Qian FMisra SPrabhu KS.Selenium and selenoproteins in prostanoid metabolism and immunity[J].Crit Rev Biochem Mol Biol201954(6):484-516.DOI:10.1080/10409238.2020.1717430.
[12]
Ghasemi FKhoshmirsafa MSafari E,et al.Vitamin E and selenium improve mesenchymal stem cell conditioned media immunomodulatory effects[J].Stem Cell Investig2021(8):9.DOI:10.21037/sci-2020-008.
[13]
Rayman MP. Selenium intake, status, and health: a complex relationship[J].Hormones (Athens)202019(1):9-14.DOI:10.1007/s42000-019-00125-5.
[14]
王宇璇,孟淑娟,王雅栋,等.人体内硒检测与富硒食品开发的研究进展[J].食品工业科技202243(4):428-437.DOI:10.13386/j.issn1002-0306.2021020057.
[15]
Ihnatowicz PDrywien' M, Wtor P,et al.The importance of nutritional factors and dietary management of Hashimoto′s thyroiditis[J].Ann Agric Environ Med202027(2):184-193.DOI:10.26444/aaem/112331.
[16]
Charoenngam NHolick MF.Immunologic effects of vitamin D on human health and disease[J].Nutrients202012(7):2097.DOI:10.3390/nu12072097.
[17]
卢婷.25羟基维生素D与桥本甲状腺炎的关系探讨[J].山西医药杂志202251(2):203-205.DOI:10.3969/j.issn.0253-9926.2022.02.023.
[18]
Krysiak RKowalcze KOkopień B.Selenomethionine potentiates the impact of vitamin D on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis and low vitamin D status[J].Pharmacol Rep201971(2):367-373.DOI:10.1016/j.pharep.2018.12.006.
[19]
侯丽萍,耿建林,谷巍,等.硒酵母联合维生素D对实验性自身免疫甲状腺炎大鼠甲状腺相关激素及抗体的影响[J].天津医药202149(2):136-141.DOI:10.11958/20201366.
[20]
Krysiak ROkopien B.The effect of levothyroxine and selenomethionine on lymphocyte and monocyte cytokine release in women with Hashimoto′s thyroiditis[J].J Clin Endocrinol Metab201196(7):2206-2215.DOI:10.1210/jc.2010-2986.
[21]
Yu L, Zhou L, Xu E, et al. Levothyroxine monotherapy versus levothyroxine and selenium combination therapy in chronic lymphocytic thyroiditis[J].J Endocrinol Invest201740(11):1243-1250.DOI:10.1007/s40618-017-0693-z.
[22]
Wichman JWinther KHBonnema SJ,et al.Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis:a systematic review and meta-analysis[J].Thyroid201626(12):1681-1692.DOI:10.1089/thy.2016.0256.
[23]
孙海君.硒酵母联合左旋甲状腺素片治疗桥本甲状腺炎的临床效果观察[J].中外女性健康研究2020(9):46-47.
[24]
任丽媛.硒酵母联合左旋甲状腺素治疗2型糖尿病伴桥本甲状腺炎的疗效、自身抗体水平及不良反应分析[J].当代医学202026(26):169-170.DOI:10.3969/j.issn.1009-4393.2020.26.074.
[25]
Krysiak RSzkróbka WOkopień B.The effect of hypolipidemic agents on thyroid autoimmunity in women with Hashimoto′s thyroiditis treated with levothyroxine and selenomethionine[J].Exp Clin Endocrinol Diabetes2018126(5):321-326.DOI:10.1055/s-0043-120342.
[26]
Ferrari SMElia GRagusa F,et al.The protective effect of myo-inositol on human thyrocytes[J].Rev Endocr Metab Disord201819(4):355-362.DOI:10.1007/s11154-018-9476-x.
[27]
Nordio MBasciani S.Myo-inositol plus selenium supplementation restores euthyroid state in Hashimoto′s patients with subclinical hypothyroidism[J].Eur Rev Med Pharmacol Sci201721(2 Suppl):51-59.
[1] 陈絮, 詹玉茹, 王纯华. 孕妇ABO血型联合甲状腺功能检测对预测妊娠期糖尿病的临床价值[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 604-610.
[2] 李聪, 徐艳, 吴铭, 丁瑞东, 王军. 极低出生体重儿出生时血清25-羟维生素D水平与其生后早期喂养不耐受关系的临床分析[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(03): 309-314.
[3] 陈媛, 邓慧玲, 李亚萍, 张玉凤, 张瑜, 闫凯悦. 357例流行性感冒患儿血清25-羟基维生素D水平及其与重症化的关联性[J]. 中华实验和临床感染病杂志(电子版), 2022, 16(06): 410-417.
[4] 李婷, 张琳. 血清脂肪酸代谢物及维生素D水平与结直肠癌发生的关系研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 661-665.
[5] 方道成, 胡媛媛. 钙和维生素D与肾结石形成关系的研究进展[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(06): 653-656.
[6] 宋昕, 耿涛, 刘长春. 老年下呼吸道感染者血清25-羟维生素D3水平与血清炎症因子水平的关系[J]. 中华肺部疾病杂志(电子版), 2023, 16(02): 215-217.
[7] 李玲, 于艳艳, 王玉杰, 赵凯. 毛细支气管炎患儿血清25(OH)D水平与Th17/Treg平衡的关系[J]. 中华肺部疾病杂志(电子版), 2022, 15(05): 718-720.
[8] 张鹏, 张朝霞, 闫春芳, 孙斌. 硒制剂在甲状腺相关性眼病治疗中的研究进展[J]. 中华眼科医学杂志(电子版), 2022, 12(05): 316-320.
[9] 邓艳媚, 龙耀斌, 李鑫, 莫丽华. 经颅磁刺激结合前庭康复训练对ADHD患儿注意力缺陷的影响及临床机制[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(01): 34-38.
[10] 韩道旭, 王勉, 王艺璇, 韩晓云, 李春晓. 妊娠期高血压疾病患者血清Ca2+、25-羟维生素D、D-二聚体水平变化及临床意义[J]. 中华临床医师杂志(电子版), 2023, 17(01): 43-47.
[11] 郑家阳, 林锦钰, 王张民, 罗琴, 张琳, 秦立强, 陈婧司, 尹雪斌. 中老年硒及硒蛋白水平与血脂的关联性研究[J]. 中华临床医师杂志(电子版), 2022, 16(12): 1175-1179.
[12] 董霞, 杨卫国, 王明华. 血清维生素D及双歧杆菌水平与儿童重症龋齿的关系分析[J]. 中华临床医师杂志(电子版), 2022, 16(05): 442-446.
[13] 何亚伟, 陈皖京, 宋佳宏, 于刚, 贾犇黎, 汪泳. 肥胖患者SCH、血清维生素D水平与NAFLD严重程度关系的研究[J]. 中华肥胖与代谢病电子杂志, 2023, 09(02): 95-101.
[14] 孙畅, 赵世刚, 白文婷. 脑卒中后认知障碍与内分泌激素变化的关系[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 471-476.
[15] 俞刘珍雄, 张康睿, 杨若蕊, 刘学春, 王龙, 吴竹青, 吴君仓. 维生素D水平与接受静脉溶栓治疗的缺血性卒中患者预后的关系[J]. 中华脑血管病杂志(电子版), 2023, 17(02): 94-101.
阅读次数
全文


摘要