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中华诊断学电子杂志 ›› 2023, Vol. 11 ›› Issue (04) : 271 -275. doi: 10.3877/cma.j.issn.2095-655X.2023.04.011

综述

狼疮肾炎无创生物标志物的研究进展
郭芳芳, 李珉珉()   
  1. 510630 广州,暨南大学附属第一医院检验科
  • 收稿日期:2022-12-30 出版日期:2023-11-26
  • 通信作者: 李珉珉
  • 基金资助:
    国家自然科学基金(82172346)

Research progress on non-invasive biomarkers of lupus nephritis

Fangfang Guo, Minmin Li()   

  1. Clinical Laboratory, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
  • Received:2022-12-30 Published:2023-11-26
  • Corresponding author: Minmin Li
引用本文:

郭芳芳, 李珉珉. 狼疮肾炎无创生物标志物的研究进展[J/OL]. 中华诊断学电子杂志, 2023, 11(04): 271-275.

Fangfang Guo, Minmin Li. Research progress on non-invasive biomarkers of lupus nephritis[J/OL]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(04): 271-275.

狼疮肾炎(LN) 是系统性红斑狼疮(SLE)主要的并发症,是造成SLE患者死亡的重要原因。新型的无创生物标志物对LN的动态诊断和活动度监测具有重要意义。笔者主要对来源于血液及尿液的蛋白质类、细胞因子类及细胞外囊泡相关微小RNA等无创生物标志物进行综述,以期为LN的诊断、疾病活动度监测及预后判断提供参考思路。

Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE) that frequently leads to mortality for SLE patients. New noninvasive biomarkers play a crucial role in the dynamic diagnosis and activity monitoring of LN. In order to provide valuable insights for the diagnosis, disease activity monitoring, and prognosis evaluation of LN, this review evaluates noninvasive biomarkers, including proteins, cytokines, and extracellular vesicle-associated miRNAs from blood and urine.

表1 LN的新型生物标志物
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