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中华诊断学电子杂志 ›› 2023, Vol. 11 ›› Issue (04) : 271 -275. doi: 10.3877/cma.j.issn.2095-655X.2023.04.011

综述

狼疮肾炎无创生物标志物的研究进展
郭芳芳, 李珉珉()   
  1. 510630 广州,暨南大学附属第一医院检验科
  • 收稿日期:2022-12-30 出版日期:2023-11-26
  • 通信作者: 李珉珉
  • 基金资助:
    国家自然科学基金(82172346)

Research progress on non-invasive biomarkers of lupus nephritis

Fangfang Guo, Minmin Li()   

  1. Clinical Laboratory, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
  • Received:2022-12-30 Published:2023-11-26
  • Corresponding author: Minmin Li
引用本文:

郭芳芳, 李珉珉. 狼疮肾炎无创生物标志物的研究进展[J]. 中华诊断学电子杂志, 2023, 11(04): 271-275.

Fangfang Guo, Minmin Li. Research progress on non-invasive biomarkers of lupus nephritis[J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(04): 271-275.

狼疮肾炎(LN) 是系统性红斑狼疮(SLE)主要的并发症,是造成SLE患者死亡的重要原因。新型的无创生物标志物对LN的动态诊断和活动度监测具有重要意义。笔者主要对来源于血液及尿液的蛋白质类、细胞因子类及细胞外囊泡相关微小RNA等无创生物标志物进行综述,以期为LN的诊断、疾病活动度监测及预后判断提供参考思路。

Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE) that frequently leads to mortality for SLE patients. New noninvasive biomarkers play a crucial role in the dynamic diagnosis and activity monitoring of LN. In order to provide valuable insights for the diagnosis, disease activity monitoring, and prognosis evaluation of LN, this review evaluates noninvasive biomarkers, including proteins, cytokines, and extracellular vesicle-associated miRNAs from blood and urine.

表1 LN的新型生物标志物
[1]
Anders HJ, Saxena R, Zhao MH,et al.Lupus nephritis[J].Nat Rev Dis Primers20206(1):7.DOI:10.1038/s41572-019-0141-9.
[2]
中国狼疮肾炎诊断和治疗指南编写组.中国狼疮肾炎诊断和治疗指南[J].中华医学杂志201999(44):3441-3455.DOI:10.3760/cma.j.issn.0376-2491.2019.44.001.
[3]
Obrişcǎ B, Jurubiţǎ R, Andronesi A,et al.Histological predictors of renal outcome in lupus nephritis:the importance of tubulointerstitial lesions and scoring of glomerular lesions[J].Lupus201827(9):1455-1463.DOI:10.1177/0961203318776109.
[4]
Singh JA, Hossain A, Kotb A,et al.Comparative effectiveness of immunosuppressive drugs and corticosteroids for lupus nephritis:a systematic review and network meta-analysis[J].Syst Rev20165(1):155.DOI:10.1186/s13643-016-0328-z.
[5]
Stanley S, Vanarsa K, Soliman S,et al.Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities[J].Nat Commun202011(1):2197.DOI:10.1038/s41467-020-15986-3.
[6]
Birmingham DJ, Merchant M, Waikar SS,et al.Biomarkers of lupus nephritis histology and flare:deciphering the relevant amidst the noise[J].Nephrol Dial Transplant201732(suppl_1):i71-i79.DOI:10.1093/ndt/gfw300.
[7]
Parodis I, Tamirou F, Houssiau FA.Treat-to-target in lupus nephritis.What is the role of the repeat kidney biopsy?[J].Arch Immunol Ther Exp (Warsz)202270(1):1-8.DOI:10.1007/s00005-022-00646-9.
[8]
Hull KL, Adenwalla SF, Topham P,et al.Indications and considerations for kidney biopsy:an overview of clinical considerations for the non-specialist[J].Clin Med (Lond)202222(1):34-40.DOI:10.7861/clinmed.2021-0472.
[9]
Ferragut F, Vachetta VS, Troncoso MF,et al.ALCAM/CD166:a pleiotropic mediator of cell adhesion,stemness and cancer progression[J].Cytokine Growth Factor Rev2021(61):27-37.DOI:10.1016/j.cytogfr.2021.07.001.
[10]
Stanley S, Vanarsa K, Soliman S,et al.Author correction:comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities[J].Nat Commun202011(1):3131.DOI:10.1038/s41467-020-16944-9.
[11]
Lei R, Vu B, Kourentzi K,et al.A novel technology for home monitoring of lupus nephritis that tracks the pathogenic urine biomarker ALCAM[J].Front Immunol2022(13):1044743.DOI:10.3389/fimmu.2022.1044743.
[12]
Chalmers SA, Ayilam Ramachandran R, Garcia SJ,et al.The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses[J].J Clin Invest2022132(1).DOI:10.1172/JCI147334.
[13]
Ding H, Lin C, Cai J,et al.Urinary activated leukocyte cell adhesion molecule as a novel biomarker of lupus nephritis histology[J].Arthritis Res Ther202022(1):122.DOI:10.1186/s13075-020-02209-9.
[14]
Møller HJ.Soluble CD163[J].Scand J Clin Lab Invest201272(1):1-13.DOI:10.3109/00365513.2011.626868.
[15]
Li J, Yu YF, Liu CH, et al. Significance of M2 macrophages in glomerulonephritis with crescents[J].Pathol Res Pract2017213(9):1215-1220.DOI:10.1016/j.prp.2017.04.011.
[16]
Huang YJ, Lin CH, Yang HY,et al.Urine soluble CD163 is a promising biomarker for the diagnosis and evaluation of lupus nephritis[J].Front Immunol2022(13):935700.DOI:10.3389/fimmu.2022.935700.
[17]
Zhang T, Li H, Vanarsa K,et al.Association of urine sCD163 with proliferative lupus nephritis,fibrinoid necrosis,cellular crescents and intrarenal M2 macrophages[J].Front Immunol2020(11):671.DOI:10.3389/fimmu.2020.00671.
[18]
Mejia-Vilet JM, Zhang XL, Cruz C,et al.Urinary soluble CD163:a novel noninvasive biomarker of activity for lupus nephritis[J].J Am Soc Nephrol202031(6):1335-1347.DOI:10.1681/ASN.2019121285.
[19]
Parodis I, Gokaraju S, Zickert A,et al.ALCAM and VCAM-1 as urine biomarkers of activity and long-term renal outcome in systemic lupus erythematosus[J].Rheumatology (Oxford)202059(9):2237-2249.DOI:10.1093/rheumatology/kez528.
[20]
Yap D, Kwan L, Ma M,et al.Preemptive immunosuppressive treatment for asymptomatic serological reactivation may reduce renal flares in patients with lupus nephritis:a cohort study[J].Nephrol Dial Transplant201934(3):467-473.DOI:10.1093/ndt/gfy024.
[21]
Yu KY, Yung S, Chau MK,et al.Clinico-pathological associations of serum VCAM-1 and ICAM-1 levels in patients with lupus nephritis[J].Lupus202130(7):1039-1050.DOI:10.1177/09612033211004727.
[22]
Fasano S, Pierro L, Borgia A,et al.Biomarker panels may be superior over single molecules in prediction of renal flares in systemic lupus erythematosus:an exploratory study[J].Rheumatology (Oxford)202059(11):3193-3200.DOI:10.1093/rheumatology/keaa074.
[23]
Liu L, Wang R, Ding H,et al.The utility of urinary biomarker panel in predicting renal pathology and treatment response in Chinese lupus nephritis patients[J].PLoS One202015(10):e0240942.DOI:10.1371/journal.pone.0240942.
[24]
Nagai K, Matsubara T, Mima A,et al.Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy[J].Kidney Int200568(2):552-561.DOI:10.1111/j.1523-1755.2005.00433.x.
[25]
Mok CC, Ding HH, Kharboutli M,et al.Axl,ferritin,insulin-like growth factor binding protein 2,and tumor necrosis factor receptor type II as biomarkers in systemic lupus erythematosus[J].Arthritis Care Res (Hoboken)201668(9):1303-1309.DOI:10.1002/acr.22835.
[26]
Gong S, Xu Z, Liu Y, et al. Plasma sMer, sAxl and GAS6 levels correlate with disease activity and severity in lupus nephritis[J].Eur J Clin Invest201949(3):e13064.DOI:10.1111/eci.13064.
[27]
Parodis I, Ding H, Zickert A,et al.Serum Axl predicts histology-based response to induction therapy and long-term renal outcome in lupus nephritis[J].PLoS One201914(2):e0212068.DOI:10.1371/journal.pone.0212068.
[28]
Farah Izati A, Wong KK, Che Maraina CH.IL-23/IL-17 axis in the pathogenesis and treatment of systemic lupus erythematosus and rheumatoid arthritis[J].Malays J Pathol202042(3):333-347.
[29]
Haroon MM, Hegazy GA, Hassanien MA, et al. Significance of interleukin 23 in systemic lupus patients:relation to disease activity and damage indices[J].Biologics2023(17):1-9.DOI:10.2147/Btt.S389021.
[30]
Dedong H, Feiyan Z, Jie S,et al.Analysis of interleukin-17 and interleukin-23 for estimating disease activity and predicting the response to treatment in active lupus nephritis patients[J].Immunol Lett2019(210):33-39.DOI:10.1016/j.imlet.2019.04.002.
[31]
Talaat RM, Mohamed SF, Bassyouni IH,et al.Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients:correlation with disease activity[J].Cytokine201572(2):146-153.DOI:10.1016/j.cyto.2014.12.027.
[32]
Karasu E, Eisenhardt SU, Harant J,et al.Extracellular vesicles:packages sent with complement[J].Front Immunol2018(9):721.DOI:10.3389/fimmu.2018.00721.
[33]
Zhao Y, Wei W, Liu ML.Extracellular vesicles and lupus nephritis-new insights into pathophysiology and clinical implications[J].J Autoimmun2020(115):102540.DOI:10.1016/j.jaut.2020.102540.
[34]
Hinger SA, Cha DJ, Franklin JL,et al.Diverse long RNAs are differentially sorted into extracellular vesicles secreted by colorectal cancer cells[J].Cell Rep201825(3):715-725.e4.DOI:10.1016/j.celrep.2018.09.054.
[35]
Solé C, Cortés-Hernández J, Felip ML,et al.miR-29c in urinary exosomes as predictor of early renal fibrosis in lupus nephritis[J].Nephrol Dial Transplant201530(9):1488-1496.DOI:10.1093/ndt/gfv128.
[36]
Tangtanatakul P, Klinchanhom S, Sodsai P,et al.Down-regulation of let-7a and miR-21 in urine exosomes from lupus nephritis patients during disease flare[J].Asian Pac J Allergy Immunol201937(4):189-197.DOI:10.12932/AP-130318-0280.
[37]
Garcia-Vives E, Solé C, Moliné T, et al. The urinary exosomal miRNA expression profile is predictive of clinical response in lupus nephritis[J].Int J Mol Sci202021(4):1372.DOI:10.3390/ijms21041372.
[38]
Li Y, Xu X, Tang X,et al.MicroRNA expression profile of urinary exosomes in Type IV lupus nephritis complicated by cellular crescent[J].J Biol Res (Thessalon)2018(25):16.DOI:10.1186/s40709-018-0088-0.
[39]
Zheng C, Xie L, Qin H,et al.The role of extracellular vesicles in systemic lupus erythematosus[J].Front Cell Dev Biol2022(10):835566.DOI:10.3389/fcell.2022.835566.
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