[1] |
Raza C, Anjum R, Shakeel N.Parkinson′s disease:mechanisms,translational models and management strategies[J]. Life Sci, 2019(226):77-90.DOI: 10.1016/j.lfs.2019.03.057.
|
[2] |
Simon DK, Tanner CM, Brundin P.Parkinson disease epidemiology,pathology,genetics,and pathophysiology[J]. Clin Geriatr Med, 2020, 36(1):1-12.DOI: 10.1016/j.cger.2019.08.002.
|
[3] |
Miller IN, Cronin-Golomb A. Gender differences in Parkinson′s disease:clinical characteristics and cognition[J]. Mov Disord, 2010, 25(16):2695-2703.DOI: 10.1002/mds.23388.
|
[4] |
DeMaagd G, Philip A.Parkinson′s disease and its management:Part 1:disease entity,risk factors,pathophysiology,clinical presentation,and diagnosis[J].P T,2015,40(8):504-532.
|
[5] |
Goldman SM, Marek K, Ottman R,et al.Concordance for Parkinson′s disease in twins:a 20-year update[J]. Ann Neurol, 2019, 85(4):600-605.DOI: 10.1002/ana.25441.
|
[6] |
Acar N, Parlak H, Ozkan A,et al.The effect of docosahexaenoic acid on apelin distribution of nervous system in the experimental mouse model of Parkinson′s disease[J]. Tissue Cell, 2019(56):41-51.DOI: 10.1016/j.tice.2018.12.002.
|
[7] |
|
[8] |
Tatemoto K, Hosoya M, Habata Y,et al.Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor[J]. Biochem Biophys Res Commun, 1998, 251(2):471-476.DOI: 10.1006/bbrc.1998.9489.
|
[9] |
|
[10] |
Pope GR, Roberts EM, Lolait SJ,et al.Central and peripheral apelin receptor distribution in the mouse:species differences with rat[J]. Peptides, 2012, 33(1):139-148.DOI: 10.1016/j.peptides.2011.12.005.
|
[11] |
|
[12] |
Chen P, Wang Y, Chen L,et al.Apelin-13 protects dopaminergic neurons against rotenone-induced neurotoxicity through the AMPK/mTOR/ULK-1 mediated autophagy activation[J]. Int J Mol Sci, 2020, 21(21):8376.DOI: 10.3390/ijms21218376.
|
[13] |
Minakaki G, Menges S, Kittel A, et al. Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype[J]. Autophagy, 2018, 14(1):98-119.DOI: 10.1080/15548627.2017.1395992.
|
[14] |
Pouresmaeili-Babaki E, Esmaeili-Mahani S, Abbasnejad M,et al.Protective effect of neuropeptide Apelin-13 on 6-Hydroxydopamine-induced neurotoxicity in SH-SY5Y dopaminergic cells:involvement of its antioxidant and antiapoptotic properties[J]. Rejuvenation Res, 2018, 21(2):162-167.DOI: 10.1089/rej.2017.1951.
|
[15] |
Chapman NA, Dupré DJ, Rainey JK.The apelin receptor:physiology,pathology,cell signalling,and ligand modulation of a peptide-activated class A GPCR[J]. Biochem Cell Biol, 2014, 92(6):431-440.DOI: 10.1139/bcb-2014-0072.
|
[16] |
Jha SK, Jha NK, Kar R, et al. p38 MAPK and PI3K/AKT signalling cascades in Parkinson′s disease[J].Int J Mol Cell Med,2015,4(2):67-86.
|
[17] |
Kennedy SG, Kandel ES, Cross TK,et al.Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria[J]. Mol Cell Biol, 1999, 19(8):5800-5810.DOI: 10.1128/MCB.19.8.5800.
|
[18] |
Zeng XJ, Yu SP, Zhang L,et al. Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons[J]. Exp Cell Res, 2010, 316(11):1773-1783.DOI: 10.1016/j.yexcr.2010.02.005.
|
[19] |
Zou Y, Wang B, Fu W,et al.Apelin-13 protects PC12 cells from corticosterone-induced apoptosis through PI3K and ERKs activation[J]. Neurochem Res, 2016, 41(7):1635-1644.DOI: 10.1007/s11064-016-1878-0.
|
[20] |
Zhu J, Dou S, Jiang Y,et al.Apelin-36 exerts the cytoprotective effect against MPP(+)-induced cytotoxicity in SH-SY5Y cells through PI3K/Akt/mTOR autophagy pathway[J]. Life Sci, 2019(224):95-108.DOI: 10.1016/j.lfs.2019.03.047.
|
[21] |
Zhu J, Gao W, Shan X,et al.Apelin-36 mediates neuroprotective effects by regulating oxidative stress,autophagy and apoptosis in MPTP-induced Parkinson′s disease model mice[J]. Brain Res, 2020(1726):146493.DOI: 10.1016/j.brainres.2019.146493.
|
[22] |
Curry DW, Stutz B, Andrews ZB,et al.Targeting AMPK signaling as a neuroprotective strategy in Parkinson′s disease[J]. J Parkinsons Dis, 2018, 8(2):161-181.DOI: 10.3233/JPD-171296.
|
[23] |
Wang JF, Mei ZG, Fu Y,et al.Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway[J]. Neural Regen Res, 2018, 13(6):989-998.DOI: 10.4103/1673-5374.233441.
|
[24] |
Darabi S, Noori-Zadeh A, Rajaei F, et al. SMER28 attenuates dopaminergic toxicity mediated by 6-Hydroxydopamine in the rats via modulating oxidative burdens and autophagy-related parameters[J]. Neurochem Res, 2018, 43(12):2313-2323.DOI: 10.1007/s11064-018-2652-2.
|
[25] |
Han B, Wang L, Fu F,et al.Hydroxysafflor yellow a promotes α-synuclein clearance via regulating autophagy in rotenone-induced Parkinson′s disease mice[J]. Folia Neuropathol, 2018, 56(2):133-140.DOI: 10.5114/fn.2018.76618.
|
[26] |
Wakatsuki S, Tokunaga S, Shibata M, et al. GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration[J]. J Cell Biol, 2017, 216(2):477-493.DOI: 10.1083/jcb.201606020.
|
[27] |
Hou X, Watzlawik JO, Fiesel FC,et al.Autophagy in Parkinson′s disease[J]. J Mol Biol, 2020, 432(8):2651-2672.DOI: 10.1016/j.jmb.2020.01.037.
|
[28] |
Yang G, Li J, Cai Y,et al.Glycyrrhizic acid alleviates 6-hydroxydopamine and corticosterone-induced neurotoxicity in SH-SY5Y cells through modulating autophagy[J]. Neurochem Res, 2018, 43(10):1914-1926.DOI: 10.1007/s11064-018-2609-5.
|
[29] |
Sarkar S.Regulation of autophagy by mTOR-dependent and mTOR-independent pathways:autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers[J]. Biochem Soc Trans, 2013, 41(5):1103-1130.DOI: 10.1042/BST20130134.
|
[30] |
Khwanraj K, Madlah S, Grataitong K, et al. Comparative mRNA expression of eEF1A isoforms and a PI3K/Akt/mTOR pathway in a cellular model of Parkinson′s disease[J]. Parkinsons Dis, 2016(2016):8716016.DOI: 10.1155/2016/8716016.
|
[31] |
Alers S, Löffler AS, Wesselborg S,et al.Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy:cross talk,shortcuts,and feedbacks[J]. Mol Cell Biol, 2012, 32(1):2-11.DOI: 10.1128/MCB.06159-11.
|
[32] |
Mantzaris MD, Bellou S, Skiada V,et al.Intracellular labile iron determines H 2O 2- induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis[J]. Free Radic Biol Med, 2016(97):454-465.DOI: 10.1016/j.freeradbiomed.2016.07.002.
|
[33] |
Wu Y, Wang X, Zhou X, et al. Temporal expression of Apelin/Apelin receptor in ischemic stroke and its therapeutic potential[J]. Front Mol Neurosci, 2017(10):1.DOI: 10.3389/fnmol.2017.00001.
|
[34] |
Duan J, Cui J, Yang Z,et al.Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling[J]. J Neuroinflammation, 2019, 16(1):24.DOI: 10.1186/s12974-019-1406-7.
|
[35] |
Xu W, Li T, Gao L,et al.Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats[J]. J Neuroinflammation, 2019, 16(1):247.DOI: 10.1186/s12974-019-1620-3.
|
[36] |
Cherry JD, Olschowka JA, O′Banion MK.Neuroinflammation and M2 microglia:the good,the bad,and the inflamed[J]. J Neuroinflammation, 2014(11):98.DOI: 10.1186/1742-2094-11-98.
|
[37] |
Li R, Liu W, Yin J,et al.TSG-6 attenuates inflammation-induced brain injury via modulation of microglial polarization in SAH rats through the SOCS3/STAT3 pathway[J]. J Neuroinflammation, 2018, 15(1):231.DOI: 10.1186/s12974-018-1279-1.
|
[38] |
Zhou S, Guo X, Chen S,et al.Apelin-13 regulates LPS-induced N9 microglia polarization involving STAT3 signaling pathway[J]. Neuropeptides, 2019(76):101938.DOI: 10.1016/j.npep.2019.101938.
|
[39] |
Chen D, Lee J, Gu X, et al. Intranasal delivery of Apelin-13 is neuroprotective and promotes angiogenesis after ischemic stroke in mice[J]. ASN Neuro, 2015, 7(5):1759091415605114.DOI: 10.1177/1759091415605114.
|
[40] |
Zeng R, Luo DX, Li HP,et al.MicroRNA-135b alleviates MPP(+)-mediated Parkinson′s disease in in vitro model through suppressing FoxO1-induced NLRP3 inflammasome and pyroptosis[J]. J Clin Neurosci, 2019(65):125-133.DOI: 10.1016/j.jocn.2019.04.004.
|
[41] |
Shacham T, Sharma N, Lederkremer GZ.Protein misfolding and ER stress in Huntington′s disease[J]. Front Mol Biosci, 2019(6):20.DOI: 10.3389/fmolb.2019.00020.
|
[42] |
Zhang J, Zhang Z, Bao J,et al.Jia-Jian-Di-Huang-Yin-Zi decoction reduces apoptosis induced by both mitochondrial and endoplasmic reticulum caspase12 pathways in the mouse model of Parkinson′s disease[J]. J Ethnopharmacol, 2017(203):69-79.DOI: 10.1016/j.jep.2016.12.053.
|
[43] |
Zhu J, Dou S, Jiang Y, et al. Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson′s disease model mice through inhibiting endoplasmic reticulum stress and promoting autophagy[J]. Brain Res, 2019(1715):203-212.DOI: 10.1016/j.brainres.2019.03.027.
|
[44] |
Zhu J, Dou S, Wang C,et al.Apelin-36 mitigates MPTP/MPP+-induced neurotoxicity:involvement of α-synuclein and endoplasmic reticulum stress[J]. Brain Res, 2019(1721):146334.DOI: 10.1016/j.brainres.2019.146334.
|
[45] |
朱俊鸽.Apelin-36在MPTP诱导的帕金森病模型小鼠中的神经保护作用及机制研究[D] .济南:山东大学,2020.
|
[46] |
Kin K, Yasuhara T, Kameda M,et al.Animal models for Parkinson′s disease research:trends in the 2000s[J]. Int J Mol Sci, 2019, 20(21):5402.DOI: 10.3390/ijms20215402.
|