切换至 "中华医学电子期刊资源库"

中华诊断学电子杂志 ›› 2024, Vol. 12 ›› Issue (02) : 138 -142. doi: 10.3877/cma.j.issn.2095-655X.2024.02.014

综述

Apelin/APJ系统生理病理作用的研究进展
王睿浩1, 姜云璐1, 田艳君2,()   
  1. 1. 272067 济宁医学院精神卫生学院
    2. 272067 济宁医学院医学检验所
  • 收稿日期:2024-01-17 出版日期:2024-05-26
  • 通信作者: 田艳君
  • 基金资助:
    山东省医药卫生科技发展计划项目(202102080596); 济宁医学院大学生创新训练计划项目(cx2022129z)

Research progress on the physiological and pathological effects of apelin/APJ system

Ruihao Wang1, Yunlu Jiang1, Yanjun Tian2,()   

  1. 1. School of Mental Health, Jining Medical University, Jining 272067, China
    2. Medical Laboratory, Jining Medical University, Jining 272067, China
  • Received:2024-01-17 Published:2024-05-26
  • Corresponding author: Yanjun Tian
引用本文:

王睿浩, 姜云璐, 田艳君. Apelin/APJ系统生理病理作用的研究进展[J/OL]. 中华诊断学电子杂志, 2024, 12(02): 138-142.

Ruihao Wang, Yunlu Jiang, Yanjun Tian. Research progress on the physiological and pathological effects of apelin/APJ system[J/OL]. Chinese Journal of Diagnostics(Electronic Edition), 2024, 12(02): 138-142.

Apelin是一种多功能生物活性肽,通过与其受体APJ结合发挥相应生物学效应。Apelin/APJ系统作为机体重要调节者,广泛参与心血管系统、代谢系统、神经系统等方面的生理和病理过程。越来越多的研究表明,apelin/APJ系统可以作为临床防治疾病以及疾病预后的关键靶点。笔者主要对apelin/APJ系统的生理病理作用进行综述,并探讨其具体作用机制以及在临床应用方面的前景,以促进开发新型药物和寻找新的治疗策略。

Apelin is a multifunctional bioactive peptide that exerts corresponding biological effects by binding to its receptor APJ. The apelin/APJ system, as an important regulator of the body, is widely involved in physiological and pathological processes of the cardiovascular system, metabolic system, nervous system, and other aspects. An increasing number of studies indicate that the apelin/APJ system can serve as a key target for prevention and control, and prognosis of clinical diseases. This article provides a review of the physiological and pathological effects of the apelin/APJ system and explores the specific mechanisms and the prospects for its clinical applications, in order to promote the development of new drugs and look for new treatment strategies.

表1 人apelin氨基酸序列
图1 Apelin/APJ信号通路生物学作用注:Apelin和APJ介导的信号通路包括两个途径:G蛋白依赖的信号转导途径和G蛋白非依赖的信号转导途径;G蛋白非依赖的信号转导途径导致受体脱敏、内化、再循环,或者在受到机械刺激时引发心肌肥厚;G蛋白依赖的信号转导途径具有多种生物学作用,可以为心血管疾病、代谢疾病、神经系统疾病的治疗提供靶点;HPA为下丘脑-垂体-肾上腺;β-arrestins为抑制蛋白
[1]
Tatemoto KHosoya MHabata Y,et al.Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor[J].Biochem Biophys Res Commun1998251(2):471-476.DOI: 10.1006/bbrc.1998.9489.PMID: 9792798.
[2]
Li A, Zhao Q, Chen L, et al. Apelin/APJ system: an emerging therapeutic target for neurological diseases[J].Mol Biol Rep202350(2):1639-1653.DOI: 10.1007/s11033-022-08075-9.
[3]
田艳君,姜云璐,韩爱忠,等.Apelin/APJ系统及其基因多态性与心脑血管疾病的相关性[J].生理科学进展201950(6):423-428.DOI: 10.3969/j.issn.0559-7765.2019.06.006.
[4]
郭如烨,孟黎明,陈楠,等.Apelin/APJ系统对帕金森病模型的神经保护作用及机制研究进展[J/CD].中华诊断学电子杂志202311(4):276-282.DOI: 10.3877/cma.j.issn.2095-655X.2023.04.012.
[5]
Scimia MCHurtado CRay S,et al.APJ acts as a dual receptor in cardiac hypertrophy[J].Nature2012488(7411): 394-398.DOI: 10.1038/nature11263.
[6]
Liu YWang LShi H.The biological function of ELABELA and APJ signaling in the cardiovascular system and pre-eclampsia[J].Hypertens Res201942(7):928-934.DOI: 10.1038/s41440-018-0193-3.
[7]
Rikitake Y.The apelin/APJ system in the regulation of vascular tone: friend or foe?[J].J Biochem2021169(4):383-386.DOI: 10.1093/jb/mvaa129.
[8]
Rozwadowski JBorodzicz-Jażdżyk SCzarzasta K,et al.A review of the roles of apelin and ELABELA peptide ligands in cardiovascular disease,including heart failure and hypertension[J].Med Sci Monit2022(28):e938112.DOI: 10.12659/MSM.938112.
[9]
Tian YChen RJiang Y,et al.The protective effects and mechanisms of apelin/APJ system on ischemic stroke: a promising therapeutic target[J].Front Neurol2020(11):75.DOI: 10.3389/fneur.2020.00075.
[10]
Perjés ÁSkoumal RTenhunen O,et al.Apelin increases cardiac contractility via protein kinase Cε-and extracellular signal-regulated kinase-dependent mechanisms[J].PLoS One20149(4):e93473.DOI: 10.1371/journal.pone.0093473.
[11]
陈柏荣,罗礼云,黄茵,等.Apelin-13在自发性高血压大鼠心肌组织的表达及其与心肌肥厚和心功能的关系[J].中国动脉硬化杂志201624(4):375-380.
[12]
Li CCheng HAdhikari BK,et al.The role of apelin-APJ system in diabetes and obesity[J].Front Endocrinol (Lausanne)2022(13):820002.DOI: 10.3389/fendo.2022.820002.
[13]
Gao ZZhong XTan YX, et al. Apelin-13 alleviates diabetic nephropathy by enhancing nitric oxide production and suppressing kidney tissue fibrosis[J].Int J Mol Med202148(3):175.DOI:10.3892/ijmm.2021.5008.
[14]
Chen HZheng CZhang X,et al.Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice[J].Peptides201132(8):1634-1639.DOI:10.1016/j.peptides.2011.06.025.
[15]
Jiang YWang SLiu X.Low serum apelin levels are associated with mild cognitive impairment in type 2 diabetic patients[J].BMC Endocr Disord202222(1):137.DOI: 10.1186/s12902-022-01051-1.
[16]
王琦,翟爱华,刘玉林,等.Apelin在糖尿病和糖尿病微血管病变中作用的研究进展[J].中国老年学杂志202343(21):5362-5366.DOI: 10.3969/j.issn.1005-9202.2023.21.065.
[17]
Tasci IErdem GOzgur G,et al.LDL-cholesterol lowering increases plasma apelin in isolated hypercholesterolemia[J].Atherosclerosis2009204(1):222-228.DOI:10.1016/j.atherosclerosis.2008.08.030.
[18]
Yamamoto THabata YMatsumoto Y,et al.Apelin-transgenic mice exhibit a resistance against diet-induced obesity by increasing vascular mass and mitochondrial biogenesis in skeletal muscle[J].Biochim Biophys Acta20111810(9):853-862.DOI: 10.1016/j.bbagen.2011.05.004.
[19]
Yue PJin HXu S,et al.Apelin decreases lipolysis via G(q),G(i),and AMPK-Dependent Mechanisms[J].Endocrinology2011152(1):59-68.DOI: 10.1210/en.2010-0576.
[20]
Huang JKang SPark SJ,et al.Apelin protects against liver X receptor-mediated steatosis through AMPK and PPARα in human and mouse hepatocytes[J].Cell Signal2017(39):84-94.DOI: 10.1016/j.cellsig.2017.08.003.
[21]
Fraga-Silva RASeeman HMontecucco F,et al.Apelin-13 treatment enhances the stability of atherosclerotic plaques[J].Eur J Clin Invest201848(3):e12891.DOI:10.1111/eci.12891.
[22]
De Mota NReaux-Le Goazigo AEl Messari S,et al.Apelin,a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release[J].Proc Natl Acad Sci U S A2004101(28):10464-10469.DOI: 10.1073/pnas.0403518101.
[23]
Tian YWang RLiu L,et al.The regulatory effects of the apelin/APJ system on depression:a prospective therapeutic target[J].Neuropeptides2023(102):102382.DOI: 10.1016/j.npep.2023.102382.
[24]
Lee DKJeong JHOh S,et al.Apelin-13 enhances arcuate POMC neuron activity via inhibiting M-current[J].PLoS One201510(3):e0119457.DOI: 10.1371/journal.pone.0119457.
[25]
Drougard ADuparc TBrenachot X,et al.Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes[J].Antioxid Redox Signal201420(4):557-573.DOI: 10.1089/ars.2013.5182.
[26]
Drougard AFournel AMarlin A,et al.Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice[J].Sci Rep2016(6):31849.DOI: 10.1038/srep31849.
[27]
Charles CJ, Rademaker MT, Richards AM. Apelin-13 induces a biphasic haemodynamic response and hormonal activation in normal conscious sheep[J].J Endocrinol2006189(3):701-710.DOI: 10.1677/joe.1.06804.
[28]
Newson MJPope GRRoberts EM,et al.Stress-dependent and gender-specific neuroregulatory roles of the apelin receptor in the hypothalamic-pituitary-adrenal axis response to acute stress[J].J Endocrinol2013216(1):99-109.DOI: 10.1530/JOE-12-0375.
[29]
Lv SYChen WDWang YD.The apelin/APJ system in psychosis and neuropathy[J].Front Pharmacol2020(11):320.DOI: 10.3389/fphar.2020.00320.
[30]
Haghparast EEsmaeili-Mahani SAbbasnejad M,et al.Apelin-13 ameliorates cognitive impairments in 6-hydroxydopamine-induced substantia nigra lesion in rats[J].Neuropeptides2018(68):28-35.DOI: 10.1016/j.npep.2018.01.001.
[31]
Zhu J, Dou S, Jiang Y, et al. Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson′s disease model mice through inhibiting endoplasmic reticulum stress and promoting autophagy[J].Brain Res2019(1715):203-212.DOI: 10.1016/j.brainres.2019.03.027.
[32]
Gok Oguz E, Akoglu H, Ulusal Okyay G, et al. Serum apelin is associated with affective disorders in peritoneal dialysis patients[J].Ren Fail201638(7):1059-1066.DOI: 10.1080/0886022X.2016.1193873.
[33]
Dai TTWang BXiao ZY,et al. Apelin-13 upregulates BDNF against chronic stress-induced depression-like phenotypes by ameliorating HPA axis and hippocampal glucocorticoid receptor dysfunctions[J].Neuroscience2018(390):151-159.DOI: 10.1016/j.neuroscience.2018.08.018.
[34]
Xiao ZYWang BFu W,et al.The hippocampus is a critical site mediating antidepressant-like activity of apelin-13 in rats[J].Neuroscience2018(375):1-9.DOI: 10.1016/j.neuroscience.2018.02.001.
[35]
Fan JGuang HZhang H,et al.SIRT1 mediates apelin-13 in ameliorating chronic normobaric hypoxia-induced anxiety-like behavior by suppressing NF-κB pathway in mice hippocampus[J].Neuroscience2018(381):22-34.DOI: 10.1016/j.neuroscience.2018.04.013.
[36]
Gourdy P, Cazals L, Thalamas C, et al. Apelin administration improves insulin sensitivity in overweight men during hyperinsulinaemic-euglycaemic clamp[J].Diabetes Obes Metab201820(1):157-164.DOI: 10.1111/dom.13055.
[1] 章建全, 程杰, 陈红琼, 闫磊. 采用ACR-TIRADS评估甲状腺消融区的调查研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 966-971.
[2] 郝玥萦, 毛盈譞, 张羽, 汪佳旭, 韩林霖, 匡雯雯, 孟瑶, 杨秀华. 超声引导衰减参数成像评估肝脂肪变性及其对心血管疾病风险的预测价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(08): 770-777.
[3] 曹雯佳, 刘学兵, 罗安果, 钟释敏, 邓岚, 王玉琳, 李赵欢. 超声矢量血流成像对2型糖尿病患者颈动脉壁剪切应力的研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(07): 709-717.
[4] 张晋伟, 董永红, 王家璇. 基于GBD2021 数据库对中国与全球老年人疝疾病负担和健康不平等的分析比较[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 708-716.
[5] 詹济玮, 蔡柳春, 温琼娜, 郭石生, 温春妹, 温鹤明. 布地格福联合噻托溴铵治疗AECOPD 的临床分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 823-826.
[6] 宋新雅, 苏小慧, 卞士柱, 丁小涵. 吸入性药物治疗肺动脉高压的研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 831-835.
[7] 刘璐璐, 何羽. 慢性阻塞性肺病患者睡眠障碍的研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 836-839.
[8] 袁园园, 岳乐淇, 张华兴, 武艳, 李全海. 间充质干细胞在呼吸系统疾病模型中肺组织分布及治疗机制的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 374-381.
[9] 周迪, 全志伟. 规范化胆囊良性疾病诊治流程减少胆囊癌误诊误治[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 749-753.
[10] 周学锋, 董哲毅, 冯哲, 蔡广研, 陈香美. 糖尿病肾脏疾病中西医结合诊疗指南计划书[J/OL]. 中华肾病研究电子杂志, 2024, 13(06): 301-305.
[11] 冯熔熔, 苏晓乐, 王利华. 慢性肾脏病患者并发心血管疾病相关生物标志物研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(05): 273-278.
[12] 贾玲玲, 滕飞, 常键, 黄福, 刘剑萍. 心肺康复在各种疾病中应用的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 859-862.
[13] 丁洪基, 赵长江, 孙鹏飞, 王灿, 王贵珍, 李龙龙. 细胞焦亡与疾病的关系研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 682-686.
[14] 闫维, 张二明, 张克, 安欣华, 向平超. 北京市石景山区40岁及以上居民早期慢性阻塞性肺疾病异质性及影响因素分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 533-540.
[15] 胡云鹤, 周玉焯, 付瑞瑛, 于凡, 李爱东. CHS-DRG付费制度下GB1分组住院费用影响因素分析与管理策略探讨[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 568-574.
阅读次数
全文


摘要