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中华诊断学电子杂志 ›› 2024, Vol. 12 ›› Issue (02) : 138 -142. doi: 10.3877/cma.j.issn.2095-655X.2024.02.014

综述

Apelin/APJ系统生理病理作用的研究进展
王睿浩1, 姜云璐1, 田艳君2,()   
  1. 1. 272067 济宁医学院精神卫生学院
    2. 272067 济宁医学院医学检验所
  • 收稿日期:2024-01-17 出版日期:2024-05-26
  • 通信作者: 田艳君
  • 基金资助:
    山东省医药卫生科技发展计划项目(202102080596); 济宁医学院大学生创新训练计划项目(cx2022129z)

Research progress on the physiological and pathological effects of apelin/APJ system

Ruihao Wang1, Yunlu Jiang1, Yanjun Tian2,()   

  1. 1. School of Mental Health, Jining Medical University, Jining 272067, China
    2. Medical Laboratory, Jining Medical University, Jining 272067, China
  • Received:2024-01-17 Published:2024-05-26
  • Corresponding author: Yanjun Tian
引用本文:

王睿浩, 姜云璐, 田艳君. Apelin/APJ系统生理病理作用的研究进展[J]. 中华诊断学电子杂志, 2024, 12(02): 138-142.

Ruihao Wang, Yunlu Jiang, Yanjun Tian. Research progress on the physiological and pathological effects of apelin/APJ system[J]. Chinese Journal of Diagnostics(Electronic Edition), 2024, 12(02): 138-142.

Apelin是一种多功能生物活性肽,通过与其受体APJ结合发挥相应生物学效应。Apelin/APJ系统作为机体重要调节者,广泛参与心血管系统、代谢系统、神经系统等方面的生理和病理过程。越来越多的研究表明,apelin/APJ系统可以作为临床防治疾病以及疾病预后的关键靶点。笔者主要对apelin/APJ系统的生理病理作用进行综述,并探讨其具体作用机制以及在临床应用方面的前景,以促进开发新型药物和寻找新的治疗策略。

Apelin is a multifunctional bioactive peptide that exerts corresponding biological effects by binding to its receptor APJ. The apelin/APJ system, as an important regulator of the body, is widely involved in physiological and pathological processes of the cardiovascular system, metabolic system, nervous system, and other aspects. An increasing number of studies indicate that the apelin/APJ system can serve as a key target for prevention and control, and prognosis of clinical diseases. This article provides a review of the physiological and pathological effects of the apelin/APJ system and explores the specific mechanisms and the prospects for its clinical applications, in order to promote the development of new drugs and look for new treatment strategies.

表1 人apelin氨基酸序列
图1 Apelin/APJ信号通路生物学作用注:Apelin和APJ介导的信号通路包括两个途径:G蛋白依赖的信号转导途径和G蛋白非依赖的信号转导途径;G蛋白非依赖的信号转导途径导致受体脱敏、内化、再循环,或者在受到机械刺激时引发心肌肥厚;G蛋白依赖的信号转导途径具有多种生物学作用,可以为心血管疾病、代谢疾病、神经系统疾病的治疗提供靶点;HPA为下丘脑-垂体-肾上腺;β-arrestins为抑制蛋白
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