Abstract:
Objective To study the relationship of ankle-brachial index(ABI) and the urinary albumin, soluble intercellular adhesion molecule-1(sICAM-1) in patients with type 2 diabetic peripheral arterial disease (PAD).
Methods Three hundred and forty-two patients with T2DM were divided into two groups according to the results of ABI, forty-eight cases in PAD group(ABI≤0.9) and two hundred and ninty four cases in non-PAD group(0.9<ABI≤1.3). At the same time, urinary albumin(μAlb), sICAM-1, triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), fasting blood glucose (FBG), 2-hour postprandial blood glucose (2hBG) of all patients were tested.The value of the two groups were compared by t-test, and the correlations were analyzed by liner-regression analysis.
Results μAlb[(125.4±108.2)mg, (67.6±55.5)mg, t=5.47, P<0.05], sICAM-1 [(278.6±234.1)ng/ml, (161.5±115.2)ng/ml, t=5.01, P<0.05], the age[(67.7±15.4) years, (54.2±12.8) years, t=3.08, P<0.05], diabetic history[(15.4±14.1) years, (8.2±7.5) years, t=4.06, P<0.05], LDL-C[(1.8±1.7)mmol/L, (1.0±1.1)mmol/L, t=6.85, P<0.05], 2hBG[(15.8±5.2)mmol/L, (11.0±4.4)mmol/L, t=2.96, P<0.05] in PAD group were higher than those in non-PAD group.ABI[(0.8±0.2), (1.2±0.2)] in PAD group was lower than that in non-PAD group (t=3.53, P<0.05). Multiple linear regression showed that ABI was correlated with μAlb (r=-0.207, P<0.05)and sICAM-1(r=-0.201, P<0.05).
Conclusion ABI can be used as index for screening peripheral arterial disease and diabetic nephropathy in patients with type 2 diabetes, and reflect its inflammatory markers.
Key words:
Diabetes mellitus, type 2,
Ankle-brachial index,
Albuminuria,
Intercellular adhesion molecule-1
Zhilian Sun, Honghui Li, Ping Tang, Jingbo Liao. Significance of ankle-brachial index in patients with type 2 diabetic peripheral arterial disease[J]. Chinese Journal of Diagnostics(Electronic Edition), 2015, 03(03): 201-203.