Diagnosis and treament of mood disorder in the patients with chronic gastritis and helicobacter pylori

doi:10.3877/cma.j.issn.2095-655X.2015.03.016

Abstract

Abstract:

Objective

To investigate the diagnosis of mood disorder in patients with chronic gastritis infected with helicobacter pylori (Hp), and explore the effects of different therapies.

Methods

The psychological status of chronic gastritis infected with Hp (two hundred and eighty cases) was analyzed with Hamilton Depression/Anxiety (HAMD /HAMA) Scales.Additionally, the patients with depression or anxiety (ninty-three cases) were randomly divided into three groups: group A received routine and antidepressant treatments, group B received antidepressant treatment and group C received routine treatment.Efficacy was assessed by patients’ perception of overall digestive symptoms and HAMD/HAMA Scales, and the infection of Hp was detected by ¹³C-urea Breath test (¹³C-UBT).

Results

The prevalence rate of depression or anxiety in chronic gastritis with Hp by the worry about cancer was 33.2% (93/280). The positive rate of ¹³C-UBT was 12.0% (9/30)in group A, 89.0% (25/28)in group B, 16.7% (5/30) in group C after 8-week treatment.The severity of patients’ perception of overall digestive symptoms was significantly improved in group A after 8-week treatment(25.3±4.1, 11.4±1.6, t=14.1, P<0.05), partly improved in group B (25.4±3.9, 15.3±3.1, t=5.8, P<0.05), and not improved at all in group C(25.2±4.4, 19.8±3.7, t=1.9, P>0.05). There was significant difference of overall digestive symptoms in group A or B compared with that in group C (t=7.3, 5.2; P<0.05), but the difference was not significant between group A and group B(t=2.1, P>0.05). The total clinical efficiency of mood disorder were 85.0%, 81.0% and 38.0%.

Conclusions

The prevalence rate of depression and anxiety is higher in chronic gastritis infected with Hp.Routine treatment is ineffective, and antidepressant treatment is partly effective.The combination of both treatments can effectively improve their somatic and psychiatric symptoms.

Key words: Chronic gastritis, Helicobacter pylori, Mood disorder, Antidepressant treatment

Xia Wang, Yulong Chen, Xiaofeng Zhang. Diagnosis and treament of mood disorder in the patients with chronic gastritis and helicobacter pylori[J]. Chinese Journal of Diagnostics(Electronic Edition), 2015, 03(03): 214-217.

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References 13

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组别	总例数	性别(男/女，例数)	年龄(岁，±s)	消化道症状评分(分，±s)	情绪障碍(分，±s)
组别	总例数	性别(男/女，例数)	年龄(岁，±s)	消化道症状评分(分，±s)	HAMD	HDMA
A组	30例	12/18	44.6±18.9	25.3±4.1	19.7±4.6	16.8±4.1
B组	28例	13/15	43.9±17.3	25.4±3.9	17.8±4.3	17.4±3.9
C组	30例	11/19	45.5±15.4	25.2±4.4	18.1±4.1	17.9±4.4
统计值	?	χ²＝0.59	t＝0.46	t＝0.55	t＝1.40	t＝0.52
P值	?	0.75	0.07	0.58	0.25	0.59

组别	总例数	性别(男/女，例数)	年龄(岁，±s)	消化道症状评分(分，±s)	情绪障碍(分，±s)
组别	总例数	性别(男/女，例数)	年龄(岁，±s)	消化道症状评分(分，±s)	HAMD	HDMA
A组	30例	12/18	44.6±18.9	25.3±4.1	19.7±4.6	16.8±4.1
B组	28例	13/15	43.9±17.3	25.4±3.9	17.8±4.3	17.4±3.9
C组	30例	11/19	45.5±15.4	25.2±4.4	18.1±4.1	17.9±4.4
统计值	?	χ²＝0.59	t＝0.46	t＝0.55	t＝1.40	t＝0.52
P值	?	0.75	0.07	0.58	0.25	0.59

组别	例数	疼痛	人际关系	焦虑	抑郁	能力减退	失眠	恐惧
胃炎伴Hp组	280	13.3±3.6	10.8±2.7	11.0±3.8	9.5±2.1	8.6±1.9	11.5±2.5	12.4±3.9
健康对照组	110	2.5±0.3	4.9±1.2	3.2±1.3	2.4±0.8	1.9±0.5	3.1±1.1	2.7±0.5
t值	?	51.44	29.83	30.15	48.35	54.41	49.30	40.77
P值	?	<0.05	<0.05	<0.05	<0.05	<0.05	<0.05	<0.05

组别	例数	疼痛	人际关系	焦虑	抑郁	能力减退	失眠	恐惧
胃炎伴Hp组	280	13.3±3.6	10.8±2.7	11.0±3.8	9.5±2.1	8.6±1.9	11.5±2.5	12.4±3.9
健康对照组	110	2.5±0.3	4.9±1.2	3.2±1.3	2.4±0.8	1.9±0.5	3.1±1.1	2.7±0.5
t值	?	51.44	29.83	30.15	48.35	54.41	49.30	40.77
P值	?	<0.05	<0.05	<0.05	<0.05	<0.05	<0.05	<0.05

组别		?	腹痛	早饱	嗳气	反酸	总分
A组		?	?	?	?	?	?
?	治疗前	30	21.3±3.6	28.5±2.5	23.7±4.4	27.6±5.2	25.3±4.1
?	治疗后	30	9.8±1.7	10.2±1.4	11.3±1.5	12.3±1.8	11.4±1.6
?	t值	?	15.3	17.8	12.7	10.2	14.1
?	P值	?	<0.01	<0.05	<0.05	<0.05	<0.01
B组		?	?	?	?	?	?
?	治疗前	28	22.3±3.9	27.9±2.7	24.7±4.8	27.3±4.5	25.4±3.9
?	治疗后	28	11.3±2.6	15.3±2.5	14.9±4.4	19.6±5.2	15.3±3.1
?	t值	?	5.5	9.4	6.2	3.8	5.8
?	P值	?	<0.05	<0.05	<0.05	<0.05	<0.05
C组		?	?	?	?	?	?
?	治疗前	30	21.9±3.7	28.6±2.5	24.1±3.9	26.8±4.8	25.2±4.4
?	治疗后	30	17.6±5.6	20.5±3.1	18.9±3.4	14.6±5.2	19.8±3.7
?	t值	?	2.9	1.4	1.6	6.4	1.9
?	P值	?	>0.05	>0.05	>0.05	<0.05	>0.05

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