In the explosive accidents, lungs are the most easily injured organs owing to the blast wave.The pulmonary blast injury (PBI) constitutes the key aspect in the diagnosis and therapy of explosive blast injury.Presently, the diagnosis of PBI mainly depends on the symptom, signs, blood gas analysis and imaging of the wounded.The clinical treatment focuses on the ventilation improvement, restrictive fluid infusion, prevention of air embolism, treatment of possible infectious implications as well as necessary surgical procedures.However, with the social development, the categories, patterns, equivalent weight, physico-chemical property of explosive substance and more complicated spatial distribution of explosive sites, the state of PBI, measures of its diagnosis and therapy and prognostic outcome demonstrated the characteristics of complexity and nonlinearity.Hence, based on the 4P (preventive, predictive, personalized and participatory, 4P) medicine model, it is of great necessity to discriminate the regularity of happening and transformation of PBI from the view of translational medicine and to investigate the probability of precision treatment of PBI by given its previous theoretical results.It may propel the transformation of patterns of its diagnosis and therapy from routine experienced qualitative treatment to personalized quantative precision treatment.The aim of this study tries to supply a new paradigm for the precision diagnosis and therapy of PBI.