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Chinese Journal of Diagnostics(Electronic Edition) ›› 2016, Vol. 04 ›› Issue (04): 255-256. doi: 10.3877/cma.j.issn.2095-655X.2016.04.010

Special Issue:

• Clinical Researchs of Tumour • Previous Articles     Next Articles

Research of thymidylate synthase and its inhibitors in non-small cell lung cancer

Baohua Lu1, Tongmei Zhang1, Baolan Li1,()   

  1. 1. Department of General, Beijing Chest Hospital Affiliated to Capital Medical University, Beijing 101149, China
  • Received:2016-10-10 Online:2016-11-26 Published:2016-11-26
  • Contact: Baolan Li
  • About author:
    Corresponding author: Li Baolan, Email:

Abstract:

Thymidylate synthase(TS) is the major enzyme of antitumor drugs. Pemetrexed disodium and S-1 are the most common TS inhibitors, and widely used in the treatment of non-small cell lung cancer (NSCLC) because of their curative effect and mild side-effect. In this review, we will mainly discuss the research progress of thymidylate synthase and its inhibitors in NSCLC.

Key words: Thymidylate synthase, Carcinoma, non-small-cell lung, Enzyme inhibitors

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