Progress of high mobility group box B1 and its relationship in stroke

doi:10.3877/cma.j.issn.2095-655X.2016.04.018

Abstract

Abstract:

Inflammatory cascades have a major impact on outcome and regeneration after ischemic stroke.High mobility group box B1 (HMGB1), a pro-inflammatory cytokine, contributes to the development of atherosclerosis, ischemic brain injury, and neurovascular repair.Meanwhile, it plays a very different role in stroke.HMGB1 participates in progression of atherosclerosis through vascular endothelial hyperpermeability, harmful inflammatory response and migration of smooth muscle cells.HMGB1 is released by necrotic neuronal cells, not only reverses to injury neuronal cell, but as danger-associated molecular patterns (DAMP) to amplify inflammatory response.On the other hand, astrocyte-derived HMGB1 induces the promotion of endogenous EPCs viability and enhances neurovascular repair in post-ischemic.This review mainly focuses on the present research of HMGB1 structure, functions and relationship in stroke.

Key words: Stroke, High mobility group proteins, Atherosclerosis

Congli Jin, Haihong Zhou. Progress of high mobility group box B1 and its relationship in stroke[J]. Chinese Journal of Diagnostics(Electronic Edition), 2016, 04(04): 284-287.

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