Diagnosis and literature review of multicentric castleman disease

doi:10.3877/cma.j.issn.2095-655X.2017.01.015

Abstract

Abstract:

Objective

To explore the diagnostic features of multicentric castleman disease(MCD).

Methods

The clinical features of a MCD patient, who was diagnosed in respiratory department of the Affiliated Hospital of Jining Medical University in 2016 were analyzed.Relevant literatures were reviewed and characteristics of clinical diagnosis of MCD were summarized.

Results

A 29 year old woman was hospitalized because of fever, fatigue over ten days.Positron emission tomography computed tomography(PET/CT) showed bilateral neck, clavicle, mediastinal, bilateral axillary, retroperitoneal, abdominal, pelvic, bilateral inguinal nodes enlargement and metabolism were increased in different degrees.Bilateral pleural effusion and atelectasis, pelvic effusion bone metabolism were increased, the features were in accordance with the PET/CT manifestation of CD.Mix-MCD was diagnosed by cervical lymph node biopsy.Immunohistochemical showed CD3T lymphocytes (+ ), CD20B lymphocytes (+ ), CD21 follicular FDC showing reticular (+ ), the percentage of Ki-67 positive cells was higher than 75%, the percentage of positive cells in the follicular area was 5%~10%, CD34 blood vessels (+ ).

Conclusion

The imaging manifestations of the disease manifests certain characteristics, early biopsyhistopathological examination is helpful for diagnosis.

Key words: Multicentric, Castleman disease, Diagnosis

Min Song, Na Su, Yan Liu, Shenghua Jiang, Luning Jiang. Diagnosis and literature review of multicentric castleman disease[J]. Chinese Journal of Diagnostics(Electronic Edition), 2017, 05(01): 55-58.

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Figures/Tables 2

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