The recent advances in genome-wide association studies of depression

doi:10.3877/cma.j.issn.2095-655X.2017.02.016

Abstract

Abstract:

Depression, a very prevalent, disabling, and moderately inherited mental illness, is a serious threat to human health, causing serious psychological and economic burden to family and society.The pathogenesis of depression is complex, and the cause is of great diversity.One promising approach to the prevention and clinical treatment of depression lies in uncovering the genetic determinants of the disorder.Genome-wide association studies (GWAS) has become an effective method to study complex traits and genetic variation.Focusing on the findings from GWAS, the review summarizes what is currently known about the genetic determinants of depression, and discusses the challenges and valuable research directions of GWAS on depression, which aim to provide the basis for the etiology study and the prevention and treatment measures of depression.

Key words: Depressive disorder, Heredity, Genome-wide association studies, Polymorphism, single nucleotide

Yanjun Tian, Chuanxin Liu, Haiqing Liu, Bo Bai. The recent advances in genome-wide association studies of depression[J]. Chinese Journal of Diagnostics(Electronic Edition), 2017, 05(02): 140-143.

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