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Chinese Journal of Diagnostics(Electronic Edition) ›› 2017, Vol. 05 ›› Issue (03): 200-204. doi: 10.3877/cma.j.issn.2095-655X.2017.03.015

Special Issue:

• Clinical Study • Previous Articles     Next Articles

Clinical characteristics and electroencephalogram pattern of anti-GABAB receptor encephalitis

Guangzhen Shan1, Wei Chen1,(), Juan Zheng2   

  1. 1. Department of Neurology, Liaocheng People′s Hospital, Liaocheng 252000, China
    2. Department of Translational Medical Laboratory, Liaocheng People′s Hospital, Liaocheng 252000, China
  • Received:2017-06-29 Online:2017-08-26 Published:2017-08-26
  • Contact: Wei Chen
  • About author:
    Corresponding author: Chen Wei, Email:

Abstract:

Objective

To observe the clinical scalp electroencephalogram (EEG) characteristics and prognostic analysis of anti-GABAB receptor encephalitis.

Methods

The clinical data of 3 patients of anti-GABAB receptor encephalitis who were treated in Neurology of Liaocheng People′s Hospital were reviewed retrospectively.

Results

The clinical manifestations of 3 patients (two male and one female) were refractory epilepsy, psychiatric behavioral symptoms and memory deficits.EEG showed focal epilepsic discharge or abnormal slow wave in 3 cases and long-term video EEG (VEEG) recorded different stages of EEG.VEEG of 2 patients with anti-GABAB receptor encephalitis were recorded during NCSE.Lung mass was found in two patients by chest CT.All patients were treated with combined first-line immunomodulatory therapies with steroids or intravenous immunoglobulin.1 patient died, 1 patient recovered and 1 patient recurred.

Conclusions

There are different EEG characteristics at different times in anti-GABAB receptor encephalitis.Three cases with anti-GABAB receptor antibody presented an initial symptom, with refractory epilepsy.Two of them accompanied with lung tumor.The patients with unincorporated lung tumor active immunotherapy can get good prognosis.

Key words: Anti-GABAB receptor encephalitis, Electroencephalography, Clinical characteristics

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