Effect of ischemic postconditioning on heart failure after myocardial infarction in patients with acute myocardial infarction

doi:10.3877/cma.j.issn.2095-655X.2018.03.009

Abstract

Abstract:

Objective

To explore the ischemic postconditioning effects on heart failure after acute myocardial infarction.

Methods

There were 200 myocardial infarction patients within 12 h on emergency PCI, of which 100 patients received routine PCI therapy (control group), and the other 100 patients received ischemic postconditioning therapy(IPTC group). The parameters between the two groups of CK-MB, cTnI, BNP, and the LVEF, LVEDD by echocardiography were observed.

Results

3 days after myocardial infarction the cTnI level of control group (40.40±3.85)ng/ml was higher than that of IPTC group (23.12±2.36)ng/ml, the difference was statistically significant (t＝7.30，P<0.05). 14 days after myocardial infarction the BNP level of control group (2 595±239)pg/ml was higher than that of IPTC group (1 391±154)pg/ml, the difference was statistically significant (t＝6.54，P<0.05). 3 months after myocardial infarction the LVEF data of normal control group (48.16±4.62)mm was lower than that of IPTC group (57.11±4.43)mm, the difference was statistically significant (t＝21.50，P<0.05). 6 months after myocardial infarction the LVEF data of normal control group (49.78±6.22)mm was lower than that of IPTC group (60.41±3.94)mm, the difference was statistically significant (t＝4.67，P<0.05). 6 months after myocardial infarction the LVEDD data of control group (52.19±6.42)mm was higher than that of IPTC group (44.24±5.47)mm, the difference was statistically significant (t＝7.70，P<0.05).

Conclusion

Ischemic postconditioning could improve cardiac function after myocardial infarction, and reduce the acute myocardial infarction injury.

Key words: Ischemic postconditioning, Acute mycadial infarction, Heart failure

Yingjie Zhao, Ying Li, Fanhui Yan, Fangming Guo, Mingli Zhao, Guiliang Wang, Jingdong Zhan, Yang Wang, Yanfen Zhang. Effect of ischemic postconditioning on heart failure after myocardial infarction in patients with acute myocardial infarction[J]. Chinese Journal of Diagnostics(Electronic Edition), 2018, 06(03): 185-188.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhzdxdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-655X.2018.03.009

https://zhzdxdzzz.cma-cmc.com.cn/EN/Y2018/V06/I03/185

Figures/Tables 3

References 17

[1]	戚厚兴，崔芬，张金国，等．首发与再发急性心肌梗死患者先兆诱因及危险因素的临床研究[J/CD]．中华诊断学电子杂志，2017，5(2):98-102.
[2]	马燚，尚小明．缺血后适应对急性心肌梗死介入治疗的影响[J]．中国老年学杂志，2010，30(16):2265-2267.
[3]	于圣永，龚觉晓，陈晓栋，等．急性心肌梗死PCI术中缺血后适应的临床意义[J]．江苏医药，2009，35(4):390-392.
[4]	叶任高，陆再英．内科学.5版．北京：人民卫生出版社，2000：310-312.
[5]	Hahn JY, Song YB, Kim EK, et al. Response to letters regarding article，" Ischemic postconditioning during primary percutaneous coronary intervention: the effects of postconditioning on myocardial reperfusion in patients with ST-segment elevation myocardial infarction (POST) randomized trial" [J]．Circulation，2014，130(6):e54-e55.
[6]	魏勇，欧阳平，汪自龙，等．缺血后处理对急性心肌梗死介入治疗患者的心脏保护作用[J]．重庆医学，2012，41(9):833-835.
[7]	Loukogeorgakis SP，Panagiotidou AT，Yellon DM，et al.Postconditioniog protects against endothelial ischemia reperfusion injury in the human forearm[J]．Circulation，2006，113(7):1015-1019.
[8]	Kin H, Zhao ZQ, Sun HY, et al. Postconditioning attenuates myocardial ischemia reperfusion injury by inhibiting events in the early minutes of reperfusion[J]．Cardiovasc Res，2004，62(1):74-85.
[9]	Hong DM，Jeon Y，Lee CS，et al.Effects of remote ischemic preconditioning with postconditioning in patients undergoing off-pump coronary artery bypass surgery-randomized controlled trial[J]．Circ J，2012，76(4):884-890.
[10]	Minamino T．Cardioprotection from ischemia/reperfusion injury：basic and translational research[J]．Circ J，2012，76(5):1074-1082.
[11]	姚优修，郑哲．线粒体乙醛脱氢酶与心肌缺血再灌注损伤保护的研究进展[J]．中国循环杂志，2012，27(6):475-477.
[12]	Vinten-Johansen J，Shi W．Perconditioning and postconditioning: current knowledge，knowledge gaps，barriers to adoption，and futuredirections[J]．J Cardiovasc Pharmacol Ther，2011，16(3/4):260-266.
[13]	Zhao ZQ，Corvera JS，Halkos ME，et al.Inhibition of myocardial injury by ischemic postconditioning during reperfusion：comparison with ischemic preconditioning[J]．Am J Physiol Heart Circ Physiol，2003，285(2):H579-588.
[14]	Staat P，Rioufol G，Piot C，et al.Postconditioning the human heart [J]．Circulation，2005，112(14):2143-2148.
[15]	Lønborg J，Kelbaek H，Vejlstrup N，et al.Cardioprotective effects of ischemic postconditioning in patients treated with primary percutaneous coronary intervention，evaluated by magnetic resonance[J]．Circ Cardiovasc Interv，2010，3(1):34-41.
[16]	Hahn JY，Song YB，Kim EK，et al.Ischemic postconditioning during primary percutaneous coronary intervention: the effects of postconditioning on myocardial reperfusion in patients with ST-segment elevation myocardial infarction (POST) randomized trial[J]．Circulation，2013，128(17):1889-1896.
[17]	Skyschally A, van Caster P, Iliodromitis EK, et al. Ischemic postconditioning：experimental models and protocol algorithms[J]．Basic Res Cardiol，2009，104(5):469-483.

组别	例数	性别男/女(例)	年龄(岁，±s)	BMI(kg/m²，±s)	吸烟史(例)	高血压史(例)
对照组	100	62/38	59.41±7.54	25.77±4.68	35	64
IPTC组	100	56/44	64.79±8.42	26.62±4.91	40	76
统计值	?	χ²＝0.74	t＝1.76	t＝1.62	χ²＝0.34	χ²＝1.18
P值	?	0.38	0.09	0.12	0.81	0.15

组别	例数	性别男/女(例)	年龄(岁，±s)	BMI(kg/m²，±s)	吸烟史(例)	高血压史(例)
对照组	100	62/38	59.41±7.54	25.77±4.68	35	64
IPTC组	100	56/44	64.79±8.42	26.62±4.91	40	76
统计值	?	χ²＝0.74	t＝1.76	t＝1.62	χ²＝0.34	χ²＝1.18
P值	?	0.38	0.09	0.12	0.81	0.15

组别	例数	CK-MB(U/L)			cTnI(ng/ml)			BNP(pg/ml)
组别	例数	AMI后3 d	AMI后7 d	AMI后14 d	AMI后3 d	AMI后7 d	AMI后14 d	AMI后3 d	AMI后7 d	AMI后14 d
对照组	100	94.62±5.76	6.08±2.36	16.23±5.11	40.40±3.85	8.15±2.51	1.05±0.44	－－	1 781±174	2 595±239
IPTC组	100	102.33±3.53	4.12±1.36	13.33±2.17	23.12±2.36	7.31±1.45	0.82±0.27	－－	1 463±233	1 391±154
t值	?	4.21	0.93	2.18	7.30	9.70	1.05	－－	6.46	6.54
P值	?	0.06	0.44	0.16	0.03	0.44	0.40	－－	0.23	0.02

组别	例数	CK-MB(U/L)			cTnI(ng/ml)			BNP(pg/ml)
组别	例数	AMI后3 d	AMI后7 d	AMI后14 d	AMI后3 d	AMI后7 d	AMI后14 d	AMI后3 d	AMI后7 d	AMI后14 d
对照组	100	94.62±5.76	6.08±2.36	16.23±5.11	40.40±3.85	8.15±2.51	1.05±0.44	－－	1 781±174	2 595±239
IPTC组	100	102.33±3.53	4.12±1.36	13.33±2.17	23.12±2.36	7.31±1.45	0.82±0.27	－－	1 463±233	1 391±154
t值	?	4.21	0.93	2.18	7.30	9.70	1.05	－－	6.46	6.54
P值	?	0.06	0.44	0.16	0.03	0.44	0.40	－－	0.23	0.02

组别	例数	LVEF(%)			LVEDD(mm)
组别	例数	AMI后2周	AMI后3个月	AMI后6个月	AMI后2周	AMI后3个月	AMI后6个月
对照组	100	50.84±7.21	48.16±4.62	49.78±6.22	48.83±4.31	49.66±4.71	52.19±6.42
IPTC组	100	53.27±6.68	57.11±4.43	60.41±3.94	47.16±5.59	45.13±4.77	44.24±5.47
t值	?	1.13	21.50	4.67	4.89	3.30	7.70
P值	?	0.31	0.00	0.01	0.61	0.76	0.00

Please choose a citation manager

Content to export