Research progress of CD4+ T lymphocytes related cytokines and pathogeneis of hashimoto′s thyroiditis

doi:10.3877/cma.j.issn.2095-655X.2019.03.016

Abstract

Abstract:

Hashimoto′s thyroiditis (HT), which is an organ-specific autoimmune disease characterized by lymphocytic infiltration and thyroid fibrosis, is the most common thyroid disorder causing hypothyroidism currently. At present, the pathogenesis of HT has not been fully elucidated, genetic and environmental risk factors will affect the occurrence of abnormal immune response in thyroid. CD4⁺ T lymphocyte-associated cytokines play an indispensable role in the progression of the HT autoimmune thyroid disease. CD4⁺ T cells can differentiate into two cell forms: the helper T cells and regulatory T cells, and then differentiate into different functional T cells, secreting different cytokines to participate in the body′s immune regulation. A variety of cytokines, such as Interleukin (IL)-6, IL-17, IL-22 and other cytokines participate in and play a role in the progression of HT disease. This article reviews the research progress of the relationship between CD4⁺ T cells and HT.

Key words: Hashimoto′s thyroiditis, Interleukin-6, Interleukin-17, Interleukin-22

Yuanyuan Huang, Yanan Liu, Shipeng Yu. Research progress of CD4⁺ T lymphocytes related cytokines and pathogeneis of hashimoto′s thyroiditis[J]. Chinese Journal of Diagnostics(Electronic Edition), 2019, 07(03): 214-216.

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References 22

[1]	McLeod DS, Cooper DS.The incidence and prevalence of thyroid autoimmunity[J]．Endocrine，2012，42(2):252-265.
[2]	孟强，时敏敏，陈静，等．功能性促甲状腺激素受体在人微血管内皮细胞的表达[J/CD]．中华诊断学电子杂志，2018，6(1):69-72.
[3]	Ruggeri RM, Minciullo P, Saitta S，et al.Serum interleukin-22(IL-22) is increased in the early stage of Hashimoto′s thyroiditis compared to non-autoimmune thyroid disease and healthy controls[J]．Hormones (Athens)，2014，13(3):338-344.
[4]	Esfahanian F, Ghelich R, Rashidian H，et al.Increased levels of serum interleukin-17 in patients with hashimoto′s thyroiditis[J]．Indian J Endocrinol Metab，2017，21(4):551-554.
[5]	Guo H, Peng D, Yang XG，et al.A higher frequency of circulating IL-22^＋CD4^＋ T cells in Chinese patients with newly diagnosed Hashimoto's thyroiditis[J]．PLoS One，2014，9(1):e84545.
[6]	Nanba T, Watanabe M, Inoue N，et al.Increases of the Th1/Th2 cell ratio in severe Hashimoto′s disease and in the proportion of Th17 cells in intractable Graves’ disease[J]．Thyroid，2009，19(5):495-501.
[7]	Nouri Koupaee A, Mansouri P, Jahanbini H, et al. Differential expression of mRNA for T bet and GATA 3 transcription factors in peripheral blood mononuclear cells of patients with vitiligo[J]．Clin Exp Dermatol，2015，40(7):735-740.
[8]	Frisullo G, Plantone D, Marti A，et al.Type 1 immune response in progressive multiple sclerosis[J]．Neuroimmunol，2012，249(1/2):112-116.
[9]	Bedoya SK, Lam B, Lau K, et al. Th17 cells in immunity and autoimmunity[J]．Clin Dev Immunol，2013(2013):986789.
[10]	Duhen T, Geiger R, Jarrossay D，et al.Production of interleukin 22 but not interleukin 17 by a subset of human skinhoming memory T cells[J]．Nat Immunol，2009，10(8):857-863.
[11]	Sugita S, Kawazoe Y, Imai A, et al. Role of IL-22- and TNF-α-producing Th22 cells in uveitis patients with Behcet′s disease[J]．J Immunol，2013，190(11):5799-5808.
[12]	Zivancevic-Simonovic S, Mihaljevic O, Majstorovic I，et al.Cytokine production in patients with papillary thyroid cancer and associated autoimmune Hashimoto thyroiditis[J]．Cancer Immunol Immunother，2015，64(8):1011-1019.
[13]	Bai X, Sun J, Wang W，et al.Increased differentiation of Th22 cells in Hashimoto′s thyroiditis[J]．Endocr J，2014，61(12):1181-1190.
[14]	Ruggeri RM, Barresi G, Sciacchitano S，et al.Immunoexpression of the CD30 ligand/CD30 and IL-6/IL-6r signals in thyroid autoimmune diseases[J]．Histol Histopathol，2006，21(3):249-256.
[15]	Durães C, Moreira CS, Alvelos I，et al.Polymorphisms in the TNFA and IL6 genes represent risk factors for autoimmune thyroid disease[J]．PLoS One，2014，9(8):e105492.
[16]	Ruggeri RM, Sciacchitano S, Vitale A，et al.Serum hepatocyte growth factor is increased in Hashimoto′s thyroiditis whether or not it is associated with nodular goiter as compared with healthy non-goitrous individuals[J]．J Endocrinol Invest，2009，32(5):465-469.
[17]	Konca Degertekin C, Aktas Yilmaz B, Balos Toruner F，et al.Circulating Th17 cytokine levels are altered in Hashimoto’s thyroiditis[J]．Cytokine，2016(80):13-17.
[18]	Shi Y, Wang H, Su Z，et al.Differentiation imbalance of Th1/Th17 in peripheral blood mononuclear cells might contribute to pathogenesis of Hashimoto’s thyroiditis[J]．Scand J Immunol，2010，72(3):250-255.
[19]	Li D, Cai W, Gu R，et al.Th17 cell plays a role in the pathogenesis of Hashimoto′s thyroiditis in patients[J]．Clin Immunol，2013，149(3):411-420.
[20]	Figueroa-Vega N, Alfonso-Pérez M, Benedicto I，et al.Increased circulating pro-inflammatory cytokines and Th17 lymphocytes in Hashimoto's thyroiditis[J]．J Clin Endocrinol Metab，2010，95(2):953-962.
[21]	Li JT, Zhang Y．TREM2 regulates innate immunity in Alzheimer′s disease[J]．J Neuroinflammation，2018，15(1):107.
[22]	Zhao Y, Li X, Huang T，et al.Intracellular trafficking of TREM2 is regulated by presenilin 1[J]．Exp Mol Med，2017，49(12):e405.

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