The neuropathological mechanism of explosive blast traumatic brain injury

doi:10.3877/cma.j.issn.2095-655X.2020.02.006

Abstract

Abstract:

In global war, there have been over 25% diagnosed cases of traumatic brain injury (TBI), most of which are caused by explosive blast. Although explosive blast TBI (bTBI) shares many clinical features with closed head TBI and penetrating TBI, it has special features, such as early cerebral-edema, prolonged cerebral vasospasm and diffuse axonal injury, which are different from other brain injuries. This manuscript summarizes the physics of explosive blast generation, the interation between blast wave and the body and the injured mechanism of regional brain tissue and cells after explosive blast exposure.

Key words: Explosive blast, Brain injuries, Neropathology, Mechanism

Yuan Liu, Zaiyun Long, Jing Yu, Jie Gao, Jun Yan, Ce Yang. The neuropathological mechanism of explosive blast traumatic brain injury[J]. Chinese Journal of Diagnostics(Electronic Edition), 2020, 08(02): 95-99.

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References 37

[1]	Chapman JC, Diaz-Arrastia R．Military traumatic brain injury：a review[J]．Alzheimers Dement，2014，10(Suppl 3):S97-S104.
[2]	Adam O, Mac Donald CL, Rivet D，et al. Clinical and imaging assessment of acute combat mild traumatic brain injury in Afghanistan [J]．Neurology，2015，85(3):219-227.
[3]	Hyder AA, Wunderlich CA, Puvanachandra P，et al.The impact of traumatic brain injuries：a global perspective[J]．Neuro Rehabilitation，2007，22(5):341-353.
[4]	Ouellet S, Petel, O.On the prospective contributions of the shock physics community to outstanding issues concerning blast induced traumatic brain injury[J]．Shock Waves，2017，27(1):281-287.
[5]	Sawyer TW, Josey T, Wang Y，et al.Investigations of primary blast-induced traumatic brain injury[J]．Shock Waves, 2018，28(1):85-99.
[6]	Ritzel DV, Van AlbertS, Sajja V，et al.Acceleration from short-duration blast[J]．Shock Waves，2018(1):101-114.
[7]	Petel OE, Ouellet S．Experimental models and investigations of blast-induced traumatic brain injury [J]．Shock Waves，2018，28(1):1-3.
[8]	Cernak I, Ahmed FA. A comparative analysis of blast-induced neurotrauma and blunt traumatic brain injury reveals significant differences in injury mechanisms [J]．MedData Rev，2010(2):297-304.
[9]	Iwaskiw AS, Ott KA, Armiger RS, et al. The measurement of intracranial pressure and brain displacement due to short-duration dynamic overpressure loading [J]．Shock Waves，2018，28(1):63-83.
[10]	Thielen P, Mehoke T, Gleason J，et al.Exploration of the molecular basis of blast injury in a biofidelic model of traumatic brain injury [J]．Shock Waves，2018，28(1):115-126.
[11]	Asken BM, DeKosky ST, Clugston JR, et al. Diffusion tensor imaging (DTI) findings in adult civilian，military，and sport-related mild traumatic brain injury (mTBI)：a systematic critical review[J]．Brain Imaging Behav，2018，12(2):585-612.
[12]	Ganpule S, Daphalapurkar NP, Cetingul MP，et al.Effect of bulk modulus on deformation of the brain under rotational accelerations[J]．Shock Waves，2018，28(1):127-139.
[13]	Astafiev SV, Shulman GL, Metcalf NV, et al. Abnormal white matter blood-oxygen-level-dependent signals in chronic mild traumatic brain injury[J]．J Neurotrauma，2015，32(16):1254-1271.
[14]	Sosa MA, De Gasperi R, Paulino AJ，et al.Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injury[J]．Acta Neuropathol Commun，2013(1):51.
[15]	Terrio H, Brenner LA, Ivins BJ，et al.Traumatic brain injury screening：preliminary findings in a US Army Brigade combat team[J]．J Head Trauma Rehabil，2009，24(1):14-23.
[16]	Newman MK, Jewett B, Frampton G.Current physical medicine and rehabilitation reports[J]．Radiology，2015，70(6):835-840.
[17]	Nordstrom P, Michaëlsson K, Gustafson Y，et al.Traumatic brain injury and young onset dementia：a nationwide cohort study [J]．Ann Neurol，2014，75(3):374-381.
[18]	Bass CR, Panzer MB, Rafaels KA, et al. Brain injuries from blast [J]．Ann Biomed Eng，2012，40(1):185-202.
[19]	Lange RT, Pancholi S, Brickell TA, et al. Neuropsychological outcome from blast versus non-blast：mild traumatic brain injury in U．S.military service members [J]．J Int Neuropsychol Soc，2012，18(3):595-605.
[20]	De Palma RG, Burris DG, Champion HR，et al.Blast injuries[J]．N Engl J Med，2005(352):1335-1342.
[21]	Cernak I, Noble-Haeusslein LJ.Traumatic brain injury：an overview of pathobiology with emphasis on military populations [J]．J Cereb Blood Flow Metab，2010(30):255-266.
[22]	Yeoh S, Bell ED, Monson KL.Distribution of Blood-Brain barrier disruption in primary blast injury [J]．Ann Biomed Eng，2013，41(10):2206-2214.
[23]	Levin HS, Robertson CS.Mild traumatic brain injury in translation[J]．J Neurotrauma，2013，30(8):610-617.
[24]	Risdall JE, Carter AJ, Kirkman E，et al.Endothelial activation and chemoattractant expression are early processes in isolated blast brain injury [J]．Neuromol Med，2014，16(3):606-619.
[25]	Goldstein LE, Fisher AM, Tagge CA, et al. Chronic traumatic encephalopathy in blast exposed military veterans and a blast neurotrauma mouse model[J]．Sci Transl Med，2012，4(134):1-40.
[26]	Lippa SM, Pastorek NJ, Benge JF，et al.Postconcussive symptoms after blast and nonblast-related mild traumatic brain injuries in Afghanistan and Iraqi war veterans[J]．J Int Neuropsychol Soc，2010，16(5):856-866.
[27]	American Medical Association.International Classification of Diseases，9th revision，clinical modification (ICD-9 CM)[M]．Chicago：American Medical Association，2011.
[28]	Goodrich JA, Kim JH, Situ RR，et al.Neuronal and glial changes in the brain resulting from explosive blast in an experimental model [J]．Acta Neuropathol Commu，2016，4(1):124.
[29]	段朝霞，张洁元，陈魁君，等．爆炸冲击波所致轻度颅脑损伤的诊断与处理[J/CD]．中华诊断学电子杂志，2016，4(1):26-29.
[30]	Ryu J, Horkayne-Szakaly I, Xu L，et al.The problem of axonal injury in the brains of veterans with histories of blast exposure [J]．Acta NeuropatholCommun，2014，25(2):153.
[31]	Davenport ND, Lim KO, Armstrong MT，et al.Diffuse and spatially variable white matter disruptions are associated with blast related mild traumatic brain injury [J]．NeuroImage，2012，59(3):2017-2024.
[32]	Petrie EC, Cross DJ, Yarnykh VL，et al.Neuroimaging，behavioral，and psychological sequelae of repetitive combined blast/impact mild traumatic brain injury in Iraq and Afghanistan war veterans[J]．J Neurotrauma，2013，31(5):425-436.
[33]	Govind V, Gold S, Kaliannan K，et al.Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits [J]．J Neurotrauma，2010，27(3):483-496.
[34]	Belanger HG, Kretzmer T, Yoash-Gantz R，et al.Cognitive sequelae of blast-related versus other mechanism of brain trauma[J]．J Int Neuropsychol Soc，2009，15(1):1-8.
[35]	Gao X, Chen JH.Mild traumatic brain injury results in extensive neuronal degeneration in the cerebral cortex [J]．J Neuropathol Exp Neurol，2011，70(3):183-191.
[36]	Kana EM, Lingb Eng-Ang, Lua J. Microenvironment changes in mild traumatic brain injury [J]．Brain Res Bull，2012，87(4-5):359-372.
[37]	Wilk JE, Thomas JL, McGurk DM, et al. W．Mild traumatic brain injury (concussion) during combat：lack of association of blast mechanism with persistent postconcussive symptoms [J]．J Head Trauma Rehabil，2010，25(1):9-14.

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