Research progress of gut microbiota in the diagnosis and mechanism of depression

doi:10.3877/cma.j.issn.2095-655X.2021.02.017

Abstract

Abstract:

Depression is a common mental disorder, which has the characteristics of high disability rate, high suicide rate and difficult to treat. Now studies have found a close relationship between gut microbiota and depression, and the role of microbial markers in the diagnosis of depression is increasingly being recognized. Gut microbiota influences brain function by acting on nerve, immune, endocrine and other systems, which may play a crucial role in the occurrence and development of depression. With the gradual advancement of research, microbial markers are expected to fill the blanks in the biological diagnosis of depression.

Key words: Gut microbiota, Depression, Diagnosis, Mechanism

Xuexue Han, Rongbo Che, Jinguo Zhai, Min Chen. Research progress of gut microbiota in the diagnosis and mechanism of depression[J]. Chinese Journal of Diagnostics(Electronic Edition), 2021, 09(02): 141-144.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhzdxdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-655X.2021.02.017

https://zhzdxdzzz.cma-cmc.com.cn/EN/Y2021/V09/I02/141

References 47

[1]	陆林，沈渔邨．精神病学[M].6版．北京：人民卫生出版社，2017：392.
[2]	World Health Organization.Depression and other common mental disorders: global health estimates [R]. Geneva: WHO, 2017: 8.
[3]	Stringaris A. Editorial: what is depression？[J]. J Child Psychol Psychiatry, 2017, 58(12): 1287-1289.
[4]	Rush AJ, Trivedi MH, Wisniewski SR, et al.Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report[J]. Am J Psychiatry, 2006, 163(11): 1905-1917.
[5]	Tavakolizadeh J, Roshanaei K, Salmaninejad A, et al.MicroRNAs and exosomes in depression: potential diagnostic biomarkers[J]. J Cell Biochem, 2018, 119(5): 3783-3797.
[6]	Farzi A, Hassan AM, Zenz G, et al.Diabesity and mood disorders: multiple links through the microbiota-gut-brain axis[J]. Mol Aspects Med, 2019(66): 80-93.
[7]	Winter G, Hart RA, Charlesworth RPG, et al.Gut microbiome and depression: what we know and what we need to know[J]. Rev Neurosci, 2018, 29(6): 629-643.
[8]	Eckburg PB, Bik EM, Bernstein CN, et al.Diversity of the human intestinal microbial flora[J]. Science, 2005, 308(5728): 1635-1638.
[9]	Chen YH, Xue F, Yu SF, et al. Gut microbiota dysbiosis in depressed women: the association of symptom severity and microbiota function[J]. J Affect Disord, 2021(282): 391-400.
[10]	Makris AP, Karianaki M, Tsamis KI, et al.The role of the gut-brain axis in depression: endocrine, neural, and immune pathways[J]. Hormones (Athens), 2021, 20(1): 1-12.
[11]	Park AJ, Collins J, Blennerhassett PA, et al.Altered colonic function and microbiota profile in a mouse model of chronic depression[J]. Neurogastroenterol Motil, 2013, 25(9): 733-e575.
[12]	郑方，朱晗，周瑾，等．慢性轻度不可预知应激对小鼠肠道菌群结构的影响[J]．中国药理学通报，2018，34(11)：1533-1538.
[13]	Kelly JR, Borre Y, O′ Brien C, et al. Transferring the blues: depression-associated gut microbiota induces neurobehavioral changes in the rat[J]. J Psychiatr Res, 2016(82): 109-118.
[14]	Zheng P, Zeng B, Zhou C, et al. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism[J]. Mol Psychiatry, 2016, 21(6): 786-796.
[15]	漆靖，蔡溢，肖剑英，等．抑郁症患者肠道菌群研究[J]．中国微生态学杂志，2018，30(9)：1057-1060.
[16]	范文涛，闫咏梅，别玉龙，等．脑卒中后抑郁症患者肠道菌群的多样性分析[J]．南方医科大学学报，2016，36(10)：1305-1311.
[17]	Huang Y, Shi X, Li Z, et al.Possible association of firmicutes in the gut microbiota of patients with major depressive disorder[J]. Neuropsychiatr Dis Treat, 2018(14): 3329-3337.
[18]	蒋文捷，梁雪梅．老年抑郁症患者与肠道菌群失调的关系[J]．中华老年医学杂志，2020，39(6)：658-661.
[19]	Yang J, Zheng P, Li Y, et al.Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders[J]. Sci Adv, 2020, 6(49): eaba8555.
[20]	Zheng P, Yang J, Li YF, et al. Gut microbial signatures can discriminate unipolar from bipolar depression[J]. Adv Sci(Weinh), 2020, 7(7): 1902862.
[21]	Visconti A, Le Roy CI, Rosa F, et al.Interplay between the human gut microbiome and host metabolism[J]. Nat Commun, 2019, 10(1): 4505.
[22]	Stevens BR, Roesch L, Thiago P, et al.Depression phenotype identified by using single nucleotide exact amplicon sequence variants of the human gut microbiome[J/OL]. Mol Psychiatry, 2020.[2020-12-11]. published online ahead of print January 27, 2020]. URL
[23]	陈真竹．基于粪便代谢组学的双相抑郁诊断生物标志物筛选[D]．太原：山西医科大学，2020.
[24]	Hu S, Li A, Huang T, et al.Gut microbiota changes in patients with bipolar depression[J]. Adv Sci(Weinh), 2019, 6(14): 1900752.
[25]	Cani PD, Amar J, Iglesias MA, et al.Metabolic endotoxemia initiates obesity and insulin resistance[J]. Diabetes, 2007, 56(7): 1761-1772.
[26]	Peng Y, Shi Z, Kumaran Satyanarayanan S, et al.Fish oil alleviates LPS-induced inflammation and depressive-like behavior in mice via restoration of metabolic impairments[J]. Brain Behav Immun, 2020(90): 393-402.
[27]	Leonard BE.Inflammation and depression: a causal or coincidental link to the pathophysiology？[J]. Acta Neuropsychiatr, 2018, 30(1): 1-16.
[28]	Eyre HA, Air T, Pradhan A, et al.A meta-analysis of chemokines in major depression[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2016(68): 1-8.
[29]	赵冬梅，丁蕾，刘虹晔，等．抑郁症伴自杀的犬尿氨酸通路机制研究进展[J]．上海交通大学学报(医学版)，2019，39(7)：805-808.
[30]	Erabi H, Okada G, Shibasaki C, et al.Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis[J]. Sci Rep, 2020, 10(1): 16822.
[31]	Maes M, Kubera M, Leunis JC, et al.Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut[J]. J Affect Disord, 2012, 141(1): 55-62.
[32]	Gałecki P, Talarowska M. Inflammatory theory of depression[J]. Psychiatr Pol, 2018, 52(3): 437-447.
[33]	Hansson PB, Murison R, Lund A, et al.Cognitive functioning and cortisol profiles in first episode major depression[J]. Scand J Psychol, 2015, 56(4): 379-383.
[34]	Liu S, Guo R, Liu F, et al.Gut microbiota regulates depression-like behavior in rats through the neuroendocrine-immune-mitochondrial pathway[J]. Neuropsychiatr Dis Treat, 2020 (16): 859-869.
[35]	Liu QF, Kim HM, Lim S, et al.Effect of probiotic administration on gut microbiota and depressive behaviors in mice[J]. Daru, 2020, 28(1): 181-189.
[36]	Rosin S, Xia K, Azcarate-Peril MA, et al.A preliminary study of gut microbiome variation and HPA axis reactivity in healthy infants[J]. Psychoneuroendocrinology, 2020(124): 105046.
[37]	Misiak B, Łoniewski I, Marlicz W, et al.The HPA axis dysregulation in severe mental illness: can we shift the blame to gut microbiota？[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2020(102): 109951.
[38]	Du Y, Gao XR, Peng L, et al.Crosstalk between the microbiota-gut-brain axis and depression[J]. Heliyon, 2020, 6(6): e04097.
[39]	Berger M, Gray JA, Roth BL.The expanded biology of serotonin[J]. Annu Rev Med, 2009(60): 355-366.
[40]	Clarke G, Grenham S, Scully P, et al.The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner[J]. Mol Psychiatry, 2013, 18(6): 666-673.
[41]	Sun J, Wang F, Hu X, et al.Clostridium butyricum attenuates chronic unpredictable mild stress-induced depressive-like behavior in mice via the gut-brain axis[J]. J Agric Food Chem, 2018, 66(31): 8415-8421.
[42]	Liu WH, Chuang HL, Huang YT, et al.Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ-free mice[J]. Behav Brain Res, 2016, 298(Pt B): 202-209.
[43]	Park H, Poo MM.Neurotrophin regulation of neural circuit development and function[J]. Nat Rev Neurosci, 2013, 14(1): 7-23.
[44]	Duman RS, Monteggia LM.A neurotrophic model for stress-related mood disorders[J]. Biol Psychiatry, 2006, 59(12): 1116-1127.
[45]	Shi Y, Luan D, Song R, et al. Value of peripheral neurotrophin levels for the diagnosis of depression and response to treatment: a systematic review and meta-analysis[J]. Eur Neuropsychopharmacol, 2020(41): 40-51.
[46]	Tian P, Zou R, Song L, et al.Ingestion of Bifidobacterium longum subspecies infantis strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiota[J]. Food Funct, 2019, 10(11): 7588-7598.
[47]	Gu F, Wu Y, Liu Y, et al.Lactobacillus casei improves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota[J]. Food Funct, 2020, 11(7): 6148-6157.

Please choose a citation manager

Content to export